xamoterol-3401 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the xamoterol-3401 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAMTSL3 ADAMTS-like 3
ADGRA2 adhesion G protein-coupled receptor A2
ARTN artemin
ATG10 autophagy related 10
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide
B3GNTL1 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like 1
BANK1 B-cell scaffold protein with ankyrin repeats 1
BRF1 BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit
C10ORF12 chromosome 10 open reading frame 12
CASP2 caspase 2, apoptosis-related cysteine peptidase
CCDC64 coiled-coil domain containing 64
CCR4 chemokine (C-C motif) receptor 4
CD47 CD47 molecule
CD52 CD52 molecule
CDH8 cadherin 8, type 2
CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle)
CLCN7 chloride channel, voltage-sensitive 7
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
CYP3A7 cytochrome P450, family 3, subfamily A, polypeptide 7
DEFB126 defensin, beta 126
DGCR8 DGCR8 microprocessor complex subunit
DNASE1 deoxyribonuclease I
DOPEY2 dopey family member 2
EPM2A epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)
FAM110B family with sequence similarity 110, member B
FBXO21 F-box protein 21
FBXO4 F-box protein 4
FHL1 four and a half LIM domains 1
FMO5 flavin containing monooxygenase 5
FOXG1 forkhead box G1
GIF gastric intrinsic factor (vitamin B synthesis)
GLP1R glucagon-like peptide 1 receptor
GM2A GM2 ganglioside activator
GPER1 G protein-coupled estrogen receptor 1
GRIP2 glutamate receptor interacting protein 2
GRM1 glutamate receptor, metabotropic 1
HAO2 hydroxyacid oxidase 2 (long chain)
HECW1 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
ICA1 islet cell autoantigen 1, 69kDa
KATNB1 katanin p80 (WD repeat containing) subunit B 1
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
LAT2 linker for activation of T cells family, member 2
LGALS4 lectin, galactoside-binding, soluble, 4
LMO3 LIM domain only 3 (rhombotin-like 2)
MET MET proto-oncogene, receptor tyrosine kinase
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MRPL41 mitochondrial ribosomal protein L41
MTMR3 myotubularin related protein 3
MX1 MX dynamin-like GTPase 1
NIPAL3 NIPA-like domain containing 3
NPR1 natriuretic peptide receptor 1
NR1I2 nuclear receptor subfamily 1, group I, member 2
NRDE2 NRDE-2, necessary for RNA interference, domain containing
NUP214 nucleoporin 214kDa
PADI3 peptidyl arginine deiminase, type III
PCDHGA8 protocadherin gamma subfamily A, 8
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime
PDE9A phosphodiesterase 9A
PDXK pyridoxal (pyridoxine, vitamin B6) kinase
PHTF2 putative homeodomain transcription factor 2
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PNPLA3 patatin-like phospholipase domain containing 3
POFUT1 protein O-fucosyltransferase 1
PQLC2 PQ loop repeat containing 2
PRDX2 peroxiredoxin 2
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PTPRS protein tyrosine phosphatase, receptor type, S
RNF39 ring finger protein 39
RUNX1 runt-related transcription factor 1
SARM1 sterile alpha and TIR motif containing 1
SCNN1B sodium channel, non voltage gated 1 beta subunit
SFTPB surfactant protein B
SGCD sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)
SIGLEC7 sialic acid binding Ig-like lectin 7
SIM2 single-minded family bHLH transcription factor 2
SLC22A7 solute carrier family 22 (organic anion transporter), member 7
SLC9A5 solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5
SMR3A submaxillary gland androgen regulated protein 3A
SRRT serrate, RNA effector molecule
STS steroid sulfatase (microsomal), isozyme S
STXBP6 syntaxin binding protein 6 (amisyn)
SVEP1 sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
SYNDIG1 synapse differentiation inducing 1
T T, brachyury homolog (mouse)
TBX6 T-box 6
TJAP1 tight junction associated protein 1 (peripheral)
TMOD1 tropomodulin 1
TMOD2 tropomodulin 2 (neuronal)
UBE2B ubiquitin-conjugating enzyme E2B
UPF3A UPF3 regulator of nonsense transcripts homolog A (yeast)
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
XYLB xylulokinase homolog (H. influenzae)
ZNF343 zinc finger protein 343
ZNF362 zinc finger protein 362
ZNF384 zinc finger protein 384

decreased expression

Symbol Name
A2M alpha-2-macroglobulin
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain
ACTL8 actin-like 8
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28
ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BET1L Bet1 golgi vesicular membrane trafficking protein-like
BHLHE41 basic helix-loop-helix family, member e41
C14ORF79 chromosome 14 open reading frame 79
C8ORF60 chromosome 8 open reading frame 60
CACNG1 calcium channel, voltage-dependent, gamma subunit 1
CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal)
CLCF1 cardiotrophin-like cytokine factor 1
CLEC4E C-type lectin domain family 4, member E
CNTNAP1 contactin associated protein 1
DAGLA diacylglycerol lipase, alpha
DBF4B DBF4 zinc finger B
DLK2 delta-like 2 homolog (Drosophila)
DOK5 docking protein 5
DUSP13 dual specificity phosphatase 13
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase
EGLN3 egl-9 family hypoxia-inducible factor 3
ERN1 endoplasmic reticulum to nucleus signaling 1
F3 coagulation factor III (thromboplastin, tissue factor)
FAM204A family with sequence similarity 204, member A
FAM212B family with sequence similarity 212, member B
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2
GADD45G growth arrest and DNA-damage-inducible, gamma
GAST gastrin
GJA9 gap junction protein, alpha 9, 59kDa
GLRA1 glycine receptor, alpha 1
GMPR guanosine monophosphate reductase
GPRC5D G protein-coupled receptor, class C, group 5, member D
GPRIN2 G protein regulated inducer of neurite outgrowth 2
HAAO 3-hydroxyanthranilate 3,4-dioxygenase
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HIST1H4A histone cluster 1, H4a
HIST1H4E histone cluster 1, H4e
HYAL1 hyaluronoglucosaminidase 1
HYAL3 hyaluronoglucosaminidase 3
IRF2BP1 interferon regulatory factor 2 binding protein 1
ITM2C integral membrane protein 2C
KDM8 lysine (K)-specific demethylase 8
KRT83 keratin 83, type II
LAIR2 leukocyte-associated immunoglobulin-like receptor 2
LARP6 La ribonucleoprotein domain family, member 6
LAX1 lymphocyte transmembrane adaptor 1
LINC00597 long intergenic non-protein coding RNA 597
LOC729164 hCG1732469
MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1
MRPL52 mitochondrial ribosomal protein L52
MSI1 musashi RNA-binding protein 1
NKX3-2 NK3 homeobox 2
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein
NPM3 nucleophosmin/nucleoplasmin 3
OCLM oculomedin
OXCT2 3-oxoacid CoA transferase 2
PACS1 phosphofurin acidic cluster sorting protein 1
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta
PIGR polymeric immunoglobulin receptor
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2
PLXNB3 plexin B3
PODNL1 podocan-like 1
PODXL2 podocalyxin-like 2
PRAMEF11 PRAME family member 11
RAD54L2 RAD54-like 2 (S. cerevisiae)
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RNF126P1 ring finger protein 126 pseudogene 1
RNF2 ring finger protein 2
RNF43 ring finger protein 43
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1
S100A9 S100 calcium binding protein A9
SCN10A sodium channel, voltage gated, type X alpha subunit
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SPINK5 serine peptidase inhibitor, Kazal type 5
SPRR2B small proline-rich protein 2B
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SPTBN2 spectrin, beta, non-erythrocytic 2
STMN3 stathmin-like 3
SYNC syncoilin, intermediate filament protein
TBX19 T-box 19
TCEB3B transcription elongation factor B polypeptide 3B (elongin A2)
TGFBR3 transforming growth factor, beta receptor III
THBS3 thrombospondin 3
TM4SF4 transmembrane 4 L six family member 4
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM254 transmembrane protein 254
TNFSF18 tumor necrosis factor (ligand) superfamily, member 18
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VEGFB vascular endothelial growth factor B
WDR62 WD repeat domain 62
WDR78 WD repeat domain 78
XDH xanthine dehydrogenase
ZCCHC24 zinc finger, CCHC domain containing 24
ZNF10 zinc finger protein 10
ZNF136 zinc finger protein 136