xeroderma pigmentosum Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores
Category disease or phenotype associations
Type disease
Description An autosomal recessive disease that is characterized by a deficiency in the ability to repair ultraviolet damage that has_material_basis_in autosomal recessive inheritance of DNA repair. (Human Disease Ontology, DOID_0050427)
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Genes

202 genes co-occuring with the disease xeroderma pigmentosum in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
XPA xeroderma pigmentosum, complementation group A 3.62001
XPC xeroderma pigmentosum, complementation group C 3.27728
ERCC2 excision repair cross-complementation group 2 3.18271
ERCC5 excision repair cross-complementation group 5 2.83474
POLH polymerase (DNA directed), eta 2.75926
DDB1 damage-specific DNA binding protein 1, 127kDa 2.57944
ERCC4 excision repair cross-complementation group 4 2.52114
DDB2 damage-specific DNA binding protein 2, 48kDa 2.3391
ERCC1 excision repair cross-complementation group 1 2.19776
ERCC3 excision repair cross-complementation group 3 2.13466
GTF2H4 general transcription factor IIH, polypeptide 4, 52kDa 2.00608
RAD23B RAD23 homolog B (S. cerevisiae) 2.00562
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1 1.7623
CETN2 centrin, EF-hand protein, 2 1.68181
POLM polymerase (DNA directed), mu 1.67006
GTF2H5 general transcription factor IIH, polypeptide 5 1.60055
CUL4A cullin 4A 1.57467
TP53 tumor protein p53 1.50052
RAD23A RAD23 homolog A (S. cerevisiae) 1.42367
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3 1.39826
CDK7 cyclin-dependent kinase 7 1.39258
RPA1 replication protein A1, 70kDa 1.38734
FEN1 flap structure-specific endonuclease 1 1.23256
GPN1 GPN-loop GTPase 1 1.21132
REV1 REV1, polymerase (DNA directed) 1.20353
OGG1 8-oxoguanine DNA glycosylase 1.17464
PCNA proliferating cell nuclear antigen 1.16863
XAB2 XPA binding protein 2 1.16521
LIG1 ligase I, DNA, ATP-dependent 1.11772
BRIP1 BRCA1 interacting protein C-terminal helicase 1 1.08789
ERCC6 excision repair cross-complementation group 6 1.0627
POLI polymerase (DNA directed) iota 1.0585
DDX11L8 DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11 like 8 1.02271
DDX11 DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11 1.02271
ZNF830 zinc finger protein 830 0.994017
IMMT inner membrane protein, mitochondrial 0.944938
RPA2 replication protein A2, 32kDa 0.933313
CSH2 chorionic somatomammotropin hormone 2 0.931242
RAD18 RAD18 E3 ubiquitin protein ligase 0.875738
POLL polymerase (DNA directed), lambda 0.868777
ATM ATM serine/threonine kinase 0.856905
DHFR dihydrofolate reductase 0.856087
PTCH1 patched 1 0.849536
H2AFX H2A histone family, member X 0.843392
UBA2 ubiquitin-like modifier activating enzyme 2 0.821257
FAM96B family with sequence similarity 96, member B 0.820026
RECQL RecQ helicase-like 0.818385
APRT adenine phosphoribosyltransferase 0.805667
OBFC1 oligonucleotide/oligosaccharide-binding fold containing 1 0.804846
HIST1H2AD histone cluster 1, H2ad 0.757786
HIST1H2AJ histone cluster 1, H2aj 0.757786
H2AFV H2A histone family, member V 0.755749
H2AFB2 H2A histone family, member B2 0.755342
H2AFY2 H2A histone family, member Y2 0.753713
H2AFB1 H2A histone family, member B1 0.753713
H2AFJ H2A histone family, member J 0.752898
HIST1H2AH histone cluster 1, H2ah 0.752898
HIST1H2AM histone cluster 1, H2am 0.74883
HIST1H2AB histone cluster 1, H2ab 0.743141
HIST1H2AE histone cluster 1, H2ae 0.743141
RNF111 ring finger protein 111 0.740705
HIST1H2AG histone cluster 1, H2ag 0.735433
CDA cytidine deaminase 0.730166
WRN Werner syndrome, RecQ helicase-like 0.720058
PRIMPOL primase and polymerase (DNA-directed) 0.718039
H2AFY H2A histone family, member Y 0.708767
RECQL4 RecQ protein-like 4 0.685091
RAD54L RAD54-like (S. cerevisiae) 0.667947
RRM1 ribonucleotide reductase M1 0.654463
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.65288
LIG4 ligase IV, DNA, ATP-dependent 0.650113
RPS3 ribosomal protein S3 0.647743
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae) 0.640645
SFI1 Sfi1 homolog, spindle assembly associated (yeast) 0.632777
TDP1 tyrosyl-DNA phosphodiesterase 1 0.632777
CAT catalase 0.618268
ERCC8 excision repair cross-complementation group 8 0.61162
GADD45A growth arrest and DNA-damage-inducible, alpha 0.609666
PHGDH phosphoglycerate dehydrogenase 0.597571
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa 0.592895
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21 0.590948
CUL4B cullin 4B 0.590558
CCNH cyclin H 0.581606
UNG uracil-DNA glycosylase 0.580439
SF3B3 splicing factor 3b, subunit 3, 130kDa 0.572662
ATR ATR serine/threonine kinase 0.569163
UVRAG UV radiation resistance associated 0.565666
CNTLN centlein, centrosomal protein 0.557509
GLB1 galactosidase, beta 1 0.55712
RFC5 replication factor C (activator 1) 5, 36.5kDa 0.551298
FES FES proto-oncogene, tyrosine kinase 0.546644
BRWD1 bromodomain and WD repeat domain containing 1 0.545868
OTUD4 OTU deubiquitinase 4 0.541992
UBA1 ubiquitin-like modifier activating enzyme 1 0.537731
RFC3 replication factor C (activator 1) 3, 38kDa 0.536957
CEP164 centrosomal protein 164kDa 0.529994
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.526132
BRCA1 breast cancer 1, early onset 0.525746
NEIL1 nei endonuclease VIII-like 1 (E. coli) 0.524974
OTUD4P1 OTUD4 pseudogene 1 0.523045
PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 0.517265
DNAH8 dynein, axonemal, heavy chain 8 0.513033
RFC4 replication factor C (activator 1) 4, 37kDa 0.503441
HPRT1 hypoxanthine phosphoribosyltransferase 1 0.503058
HDAC2 histone deacetylase 2 0.499614
PAPD7 PAP associated domain containing 7 0.498849
PPIE peptidylprolyl isomerase E (cyclophilin E) 0.493503
CHEK1 checkpoint kinase 1 0.488549
MSH2 mutS homolog 2 0.486646
CBX4 chromobox homolog 4 0.485885
SMO smoothened, frizzled class receptor 0.484744
ENY2 enhancer of yellow 2 homolog (Drosophila) 0.479047
PARK2 parkin RBR E3 ubiquitin protein ligase 0.478289
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 0.476772
SPHAR S-phase response (cyclin related) 0.468441
E2F1 E2F transcription factor 1 0.468063
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) 0.463149
CPSF1 cleavage and polyadenylation specific factor 1, 160kDa 0.460129
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta 0.455601
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.449571
MPG N-methylpurine-DNA glycosylase 0.445805
C1D C1D nuclear receptor corepressor 0.443171
RCHY1 ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase 0.442418
PGPEP1 pyroglutamyl-peptidase I 0.44129
GSTP1 glutathione S-transferase pi 1 0.438658
KAT2A K(lysine) acetyltransferase 2A 0.430768
SIRT1 sirtuin 1 0.430768
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.42364
PDS5B PDS5 cohesin associated factor B 0.42214
PSMC5 proteasome (prosome, macropain) 26S subunit, ATPase, 5 0.419517
NFE2L1 nuclear factor, erythroid 2-like 1 0.418394
SUMO3 small ubiquitin-like modifier 3 0.414276
GSTA3 glutathione S-transferase alpha 3 0.412405
RFC1 replication factor C (activator 1) 1, 145kDa 0.412031
GSTA2 glutathione S-transferase alpha 2 0.410909
GSTA4 glutathione S-transferase alpha 4 0.409787
FRRS1L ferric-chelate reductase 1-like 0.407545
PRPF19 pre-mRNA processing factor 19 0.406425
GSTA1 glutathione S-transferase alpha 1 0.404184
LIG3 ligase III, DNA, ATP-dependent 0.403438
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.401572
GTF2H1 general transcription factor IIH, polypeptide 1, 62kDa 0.400453
SHH sonic hedgehog 0.399334
SUMO2 small ubiquitin-like modifier 2 0.397471
VILL villin-like 0.393374
MMS19 MMS19 nucleotide excision repair homolog (S. cerevisiae) 0.388909
RSF1 remodeling and spacing factor 1 0.388538
HRAS Harvey rat sarcoma viral oncogene homolog 0.378143
GEN1 GEN1 Holliday junction 5' flap endonuclease 0.376661
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) 0.372217
TOP1 topoisomerase (DNA) I 0.371477
PUF60 poly-U binding splicing factor 60KDa 0.371107
YBX1 Y box binding protein 1 0.365193
PARP1 poly (ADP-ribose) polymerase 1 0.357814
TYMS thymidylate synthetase 0.351923
EXO1 exonuclease 1 0.35082
PYGO2 pygopus family PHD finger 2 0.35082
CIAO1 cytosolic iron-sulfur assembly component 1 0.346042
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2 0.346042
NMU neuromedin U 0.343106
SYCP1 synaptonemal complex protein 1 0.337608
MTHFR methylenetetrahydrofolate reductase (NAD(P)H) 0.337242
HIST2H2AC histone cluster 2, H2ac 0.332852
HIST2H2AA4 histone cluster 2, H2aa4 0.332487
HIST2H2AA3 histone cluster 2, H2aa3 0.332487
RAD50 RAD50 homolog (S. cerevisiae) 0.329565
RAD52 RAD52 homolog (S. cerevisiae) 0.326281
RNF2 ring finger protein 2 0.312102
TOP3A topoisomerase (DNA) III alpha 0.307395
RFC2 replication factor C (activator 1) 2, 40kDa 0.306672
JUN jun proto-oncogene 0.300173
RNF4 ring finger protein 4 0.286877
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.284371
CALB1 calbindin 1, 28kDa 0.28294
KLK15 kallikrein-related peptidase 15 0.282582
BAX BCL2-associated X protein 0.280796
RAD51 RAD51 recombinase 0.270108
DGAT2L6 diacylglycerol O-acyltransferase 2-like 6 0.269043
MAGED2 melanoma antigen family D2 0.267977
TPSG1 tryptase gamma 1 0.263014
KEAP1 kelch-like ECH-associated protein 1 0.261952
ACTB actin, beta 0.237009
KCP kielin/chordin-like protein 0.232142
NUDT1 nudix (nucleoside diphosphate linked moiety X)-type motif 1 0.22145
HNMT histamine N-methyltransferase 0.220081
KLF9 Kruppel-like factor 9 0.213959
ACTG1 actin gamma 1 0.209248
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2 0.207578
MUS81 MUS81 structure-specific endonuclease subunit 0.203933
MGMT O-6-methylguanine-DNA methyltransferase 0.193915
ZMPSTE24 zinc metallopeptidase STE24 0.190476
DNA2 DNA replication helicase/nuclease 2 0.18621
ADA adenosine deaminase 0.185612
WDHD1 WD repeat and HMG-box DNA binding protein 1 0.183835
RASA1 RAS p21 protein activator (GTPase activating protein) 1 0.175146
MSH6 mutS homolog 6 0.174617
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 0.172291
MBNL1 muscleblind-like splicing regulator 1 0.170789
HMGA1 high mobility group AT-hook 1 0.168148
RNF34 ring finger protein 34, E3 ubiquitin protein ligase 0.164571
SOD2 superoxide dismutase 2, mitochondrial 0.163729
CDKN2A cyclin-dependent kinase inhibitor 2A 0.15948