xiap Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase|This gene encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. This protein also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. Mutations in this gene are the cause of X-linked lymphoproliferative syndrome. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 2 and 11.[provided by RefSeq, Feb 2011] (NCBI Entrez Gene Database, 331)
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Genes

113 genes co-occuring with the biological term xiap in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ACVR1C activin A receptor, type IC
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT2 v-akt murine thymoma viral oncogene homolog 2
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
AXL AXL receptor tyrosine kinase
BAK1 BCL2-antagonist/killer 1
BAX BCL2-associated X protein
BCL2 B-cell CLL/lymphoma 2
BCL2L1 BCL2-like 1
BIRC2 baculoviral IAP repeat containing 2
BIRC3 baculoviral IAP repeat containing 3
BIRC5 baculoviral IAP repeat containing 5
BMP2 bone morphogenetic protein 2
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase)
C19ORF33 chromosome 19 open reading frame 33
CAPNS1 calpain, small subunit 1
CASP2 caspase 2, apoptosis-related cysteine peptidase
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP6 caspase 6, apoptosis-related cysteine peptidase
CASP7 caspase 7, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CASP9 caspase 9, apoptosis-related cysteine peptidase
CCND1 cyclin D1
CCS copper chaperone for superoxide dismutase
CD40LG CD40 ligand
CDK1 cyclin-dependent kinase 1
CFLAR CASP8 and FADD-like apoptosis regulator
CHEK1 checkpoint kinase 1
CHRNA7 cholinergic receptor, nicotinic, alpha 7 (neuronal)
COMMD1 copper metabolism (Murr1) domain containing 1
CRYAB crystallin, alpha B
CSE1L CSE1 chromosome segregation 1-like (yeast)
CYCS cytochrome c, somatic
DIABLO diablo, IAP-binding mitochondrial protein
DKC1 dyskeratosis congenita 1, dyskerin
ELAVL1 ELAV like RNA binding protein 1
EZR ezrin
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
GDF5 growth differentiation factor 5
GSK3B glycogen synthase kinase 3 beta
GZMM granzyme M (lymphocyte met-ase 1)
HAX1 HCLS1 associated protein X-1
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2)
HTRA1 HtrA serine peptidase 1
HTRA2 HtrA serine peptidase 2
IFNB1 interferon, beta 1, fibroblast
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
ILF2 interleukin enhancer binding factor 2
INPP5D inositol polyphosphate-5-phosphatase, 145kDa
JUN jun proto-oncogene
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LAMTOR5 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5
LGALS3 lectin, galactoside-binding, soluble, 3
MAP3K2 mitogen-activated protein kinase kinase kinase 2
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MAPK8 mitogen-activated protein kinase 8
MAPK9 mitogen-activated protein kinase 9
MCL1 myeloid cell leukemia 1
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MET MET proto-oncogene, receptor tyrosine kinase
MIR130A microRNA 130a
MIR200C microRNA 200c
MIR23A microRNA 23a
MIR4782 microRNA 4782
MUC1 mucin 1, cell surface associated
NBN nibrin
NEDD8 neural precursor cell expressed, developmentally down-regulated 8
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NOD1 nucleotide-binding oligomerization domain containing 1
NOD2 nucleotide-binding oligomerization domain containing 2
NUMB numb homolog (Drosophila)
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PEA15 phosphoprotein enriched in astrocytes 15
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PPARG peroxisome proliferator-activated receptor gamma
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme
PRF1 perforin 1 (pore forming protein)
PTEN phosphatase and tensin homolog
PXDN peroxidasin
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RHOA ras homolog family member A
RIPK2 receptor-interacting serine-threonine kinase 2
S100P S100 calcium binding protein P
SCARA3 scavenger receptor class A, member 3
SEPT4 septin 4
SIAH1 siah E3 ubiquitin protein ligase 1
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
STAG2 stromal antigen 2
STRADB STE20-related kinase adaptor beta
SYK spleen tyrosine kinase
TGFB1 transforming growth factor, beta 1
TNF tumor necrosis factor
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TP53 tumor protein p53
TP63 tumor protein p63
TPPP tubulin polymerization promoting protein
TRIM32 tripartite motif containing 32
UBC ubiquitin C
UNC13D unc-13 homolog D (C. elegans)
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)
USP8 ubiquitin specific peptidase 8
XAF1 XIAP associated factor 1
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
ZBTB16 zinc finger and BTB domain containing 16
ZFP36 ZFP36 ring finger protein