xpa Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description xeroderma pigmentosum, complementation group A|This gene encodes a zinc finger protein involved in DNA excision repair. The encoded protein is part of the NER (nucleotide excision repair) complext which is responsible for repair of UV radiation-induced photoproducts and DNA adducts induced by chemical carcinogens. Mutations in this gene are associated with xeroderma pigmentosum complementation group A. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009] (NCBI Entrez Gene Database, 7507)
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Genes

29 genes co-occuring with the biological term xpa in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ATR ATR serine/threonine kinase
CEP164 centrosomal protein 164kDa
CETN2 centrin, EF-hand protein, 2
DDB2 damage-specific DNA binding protein 2, 48kDa
ERCC1 excision repair cross-complementation group 1
ERCC2 excision repair cross-complementation group 2
ERCC4 excision repair cross-complementation group 4
ERCC5 excision repair cross-complementation group 5
FANCC Fanconi anemia, complementation group C
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HMGA1 high mobility group AT-hook 1
KIN Kin17 DNA and RNA binding protein
KPNA4 karyopherin alpha 4 (importin alpha 3)
LMNA lamin A/C
MPO myeloperoxidase
PARP1 poly (ADP-ribose) polymerase 1
PCNA proliferating cell nuclear antigen
PHF2 PHD finger protein 2
PLAU plasminogen activator, urokinase
PTCH1 patched 1
RPA1 replication protein A1, 70kDa
SIRT1 sirtuin 1
SLC30A9 solute carrier family 30 (zinc transporter), member 9
TP53 tumor protein p53
XPA xeroderma pigmentosum, complementation group A
XPC xeroderma pigmentosum, complementation group C
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6