xylazine-2132 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the xylazine-2132 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCA2 ATP-binding cassette, sub-family A (ABC1), member 2
ABCB4 ATP-binding cassette, sub-family B (MDR/TAP), member 4
ACO2 aconitase 2, mitochondrial
ACRV1 acrosomal vesicle protein 1
ACTA2 actin, alpha 2, smooth muscle, aorta
ADARB1 adenosine deaminase, RNA-specific, B1
ADRA1A adrenoceptor alpha 1A
ALDH1L1 aldehyde dehydrogenase 1 family, member L1
ANK1 ankyrin 1, erythrocytic
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
APOH apolipoprotein H (beta-2-glycoprotein I)
ATP5C1 ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1
BDKRB1 bradykinin receptor B1
C18ORF25 chromosome 18 open reading frame 25
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit
CAMSAP2 calmodulin regulated spectrin-associated protein family, member 2
CAPN9 calpain 9
CCDC121 coiled-coil domain containing 121
CCDC57 coiled-coil domain containing 57
CCDC64 coiled-coil domain containing 64
CD79B CD79b molecule, immunoglobulin-associated beta
CDK20 cyclin-dependent kinase 20
CELP carboxyl ester lipase pseudogene
COL18A1 collagen, type XVIII, alpha 1
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
DHRS2 dehydrogenase/reductase (SDR family) member 2
DHRS7 dehydrogenase/reductase (SDR family) member 7
EDA ectodysplasin A
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase
EPB41L4B erythrocyte membrane protein band 4.1 like 4B
EPHA5 EPH receptor A5
EPS8L1 EPS8-like 1
F5 coagulation factor V (proaccelerin, labile factor)
FABP3 fatty acid binding protein 3, muscle and heart
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
GAL3ST4 galactose-3-O-sulfotransferase 4
GCFC2 GC-rich sequence DNA-binding factor 2
GK2 glycerol kinase 2
GOSR2 golgi SNAP receptor complex member 2
GPR19 G protein-coupled receptor 19
GRM1 glutamate receptor, metabotropic 1
GYG2 glycogenin 2
H2AFX H2A histone family, member X
HOXA3 homeobox A3
IL27RA interleukin 27 receptor, alpha
JAM2 junctional adhesion molecule 2
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5
KCTD2 potassium channel tetramerization domain containing 2
KHK ketohexokinase (fructokinase)
KLRB1 killer cell lectin-like receptor subfamily B, member 1
LRRC16A leucine rich repeat containing 16A
MAPK11 mitogen-activated protein kinase 11
MBNL2 muscleblind-like splicing regulator 2
MCAM melanoma cell adhesion molecule
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MEF2C myocyte enhancer factor 2C
MINK1 misshapen-like kinase 1
MMP24 matrix metallopeptidase 24 (membrane-inserted)
MTA2 metastasis associated 1 family, member 2
MYH15 myosin, heavy chain 15
NEB nebulin
NEK9 NIMA-related kinase 9
NF2 neurofibromin 2 (merlin)
NR4A2 nuclear receptor subfamily 4, group A, member 2
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa
OR1D2 olfactory receptor, family 1, subfamily D, member 2
OSBPL10 oxysterol binding protein-like 10
PARD6A par-6 family cell polarity regulator alpha
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCSK6 proprotein convertase subtilisin/kexin type 6
PLK3 polo-like kinase 3
POPDC2 popeye domain containing 2
PPP1R12B protein phosphatase 1, regulatory subunit 12B
PPP1R13B protein phosphatase 1, regulatory subunit 13B
PPP2R2B protein phosphatase 2, regulatory subunit B, beta
PTCRA pre T-cell antigen receptor alpha
PYHIN1 pyrin and HIN domain family, member 1
RECQL5 RecQ protein-like 5
RUNDC3B RUN domain containing 3B
RYR1 ryanodine receptor 1 (skeletal)
RYR2 ryanodine receptor 2 (cardiac)
SIGLEC7 sialic acid binding Ig-like lectin 7
SIRPB1 signal-regulatory protein beta 1
SLC25A30 solute carrier family 25, member 30
SLC35A2 solute carrier family 35 (UDP-galactose transporter), member A2
SOCS1 suppressor of cytokine signaling 1
SOX2 SRY (sex determining region Y)-box 2
STRA6 stimulated by retinoic acid 6
TK2 thymidine kinase 2, mitochondrial
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
TP53I3 tumor protein p53 inducible protein 3
TSKU tsukushi, small leucine rich proteoglycan
UBOX5 U-box domain containing 5
UBR4 ubiquitin protein ligase E3 component n-recognin 4
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
ZNF135 zinc finger protein 135
ZNF821 zinc finger protein 821

decreased expression

Symbol Name
ARMC7 armadillo repeat containing 7
ASPN asporin
AXIN1 axin 1
BBS7 Bardet-Biedl syndrome 7
BHLHE41 basic helix-loop-helix family, member e41
C1ORF105 chromosome 1 open reading frame 105
C3 complement component 3
C6ORF47 chromosome 6 open reading frame 47
C9ORF40 chromosome 9 open reading frame 40
CA5BP1 carbonic anhydrase VB pseudogene 1
CCRL2 chemokine (C-C motif) receptor-like 2
CEP97 centrosomal protein 97kDa
CHD8 chromodomain helicase DNA binding protein 8
CHM choroideremia (Rab escort protein 1)
CTNNBIP1 catenin, beta interacting protein 1
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
DDRGK1 DDRGK domain containing 1
DENND5B DENN/MADD domain containing 5B
DHX57 DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57
DNMBP dynamin binding protein
DUSP8 dual specificity phosphatase 8
DVL1 dishevelled segment polarity protein 1
EFNA3 ephrin-A3
EGR2 early growth response 2
ENTPD6 ectonucleoside triphosphate diphosphohydrolase 6 (putative)
F3 coagulation factor III (thromboplastin, tissue factor)
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)
FHL3 four and a half LIM domains 3
FJX1 four jointed box 1 (Drosophila)
FMNL1 formin-like 1
FOSL1 FOS-like antigen 1
GAB2 GRB2-associated binding protein 2
GCH1 GTP cyclohydrolase 1
GNL3LP1 guanine nucleotide binding protein-like 3 (nucleolar)-like pseudogene 1
GRAMD1B GRAM domain containing 1B
GSDMD gasdermin D
GTF2A1 general transcription factor IIA, 1, 19/37kDa
HIST1H2AJ histone cluster 1, H2aj
HOXA5 homeobox A5
HYAL3 hyaluronoglucosaminidase 3
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
INPPL1 inositol polyphosphate phosphatase-like 1
IPPK inositol 1,3,4,5,6-pentakisphosphate 2-kinase
JMJD4 jumonji domain containing 4
KANSL1L KAT8 regulatory NSL complex subunit 1-like
KIAA1024 KIAA1024
KLHL28 kelch-like family member 28
MAP3K3 mitogen-activated protein kinase kinase kinase 3
MARCKSL1 MARCKS-like 1
METRN meteorin, glial cell differentiation regulator
MYL5 myosin, light chain 5, regulatory
NFE2L3 nuclear factor, erythroid 2-like 3
NOD1 nucleotide-binding oligomerization domain containing 1
NTSR1 neurotensin receptor 1 (high affinity)
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
P2RY1 purinergic receptor P2Y, G-protein coupled, 1
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)
PAQR6 progestin and adipoQ receptor family member VI
PCOLCE2 procollagen C-endopeptidase enhancer 2
PGP phosphoglycolate phosphatase
PHACTR1 phosphatase and actin regulator 1
PIGL phosphatidylinositol glycan anchor biosynthesis, class L
PITX2 paired-like homeodomain 2
POM121L2 POM121 transmembrane nucleoporin-like 2
POR P450 (cytochrome) oxidoreductase
PPDPF pancreatic progenitor cell differentiation and proliferation factor
PRICKLE3 prickle homolog 3 (Drosophila)
PRKAB2 protein kinase, AMP-activated, beta 2 non-catalytic subunit
PTDSS2 phosphatidylserine synthase 2
RANBP17 RAN binding protein 17
RGS13 regulator of G-protein signaling 13
RHBDF2 rhomboid 5 homolog 2 (Drosophila)
RHOBTB2 Rho-related BTB domain containing 2
RHOH ras homolog family member H
RNF121 ring finger protein 121
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1
RPA4 replication protein A4, 30kDa
RPAP2 RNA polymerase II associated protein 2
SCUBE3 signal peptide, CUB domain, EGF-like 3
SHARPIN SHANK-associated RH domain interactor
SLC25A10 solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10
SPATA7 spermatogenesis associated 7
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
STAG3L4 stromal antigen 3-like 4 (pseudogene)
STBD1 starch binding domain 1
SYCP2 synaptonemal complex protein 2
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TASP1 taspase, threonine aspartase, 1
TMEM212 transmembrane protein 212
TNNT1 troponin T type 1 (skeletal, slow)
TNRC6B trinucleotide repeat containing 6B
TTC23 tetratricopeptide repeat domain 23
USB1 U6 snRNA biogenesis 1
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
ZBTB6 zinc finger and BTB domain containing 6
ZNF254 zinc finger protein 254
ZNF354A zinc finger protein 354A