years Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
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Genes

407 genes co-occuring with the biological term years in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCA4 ATP-binding cassette, sub-family A (ABC1), member 4
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8
ABCG8 ATP-binding cassette, sub-family G (WHITE), member 8
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACAN aggrecan
ACE angiotensin I converting enzyme
ACKR1 atypical chemokine receptor 1 (Duffy blood group)
ADA adenosine deaminase
ADIPOQ adiponectin, C1Q and collagen domain containing
ADM adrenomedullin
ADRA2B adrenoceptor alpha 2B
ADRB2 adrenoceptor beta 2, surface
ADRB3 adrenoceptor beta 3
AGER advanced glycosylation end product-specific receptor
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
AMH anti-Mullerian hormone
APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
APC adenomatous polyposis coli
APOA1 apolipoprotein A-I
APOB apolipoprotein B
APOE apolipoprotein E
APP amyloid beta (A4) precursor protein
AQP4 aquaporin 4
AR androgen receptor
ARX aristaless related homeobox
AS3MT arsenite methyltransferase
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATG7 autophagy related 7
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide
ATXN2 ataxin 2
AVEN apoptosis, caspase activation inhibitor
B2M beta-2-microglobulin
BAP1 BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
BCHE butyrylcholinesterase
BCL2 B-cell CLL/lymphoma 2
BCR breakpoint cluster region
BDNF brain-derived neurotrophic factor
BEST1 bestrophin 1
BMPR1B bone morphogenetic protein receptor, type IB
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase)
BRAF B-Raf proto-oncogene, serine/threonine kinase
BRCA1 breast cancer 1, early onset
BRCA2 breast cancer 2, early onset
BST2 bone marrow stromal cell antigen 2
C3 complement component 3
CANT1 calcium activated nucleotidase 1
CAT catalase
CAV3 caveolin 3
CBS cystathionine-beta-synthase
CCL17 chemokine (C-C motif) ligand 17
CCL22 chemokine (C-C motif) ligand 22
CCL27 chemokine (C-C motif) ligand 27
CCL5 chemokine (C-C motif) ligand 5
CCND1 cyclin D1
CCR2 chemokine (C-C motif) receptor 2
CD1B CD1b molecule
CD226 CD226 molecule
CD24 CD24 molecule
CD44 CD44 molecule (Indian blood group)
CDC20 cell division cycle 20
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDK5 cyclin-dependent kinase 5
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1
CDKN2A cyclin-dependent kinase inhibitor 2A
CDX2 caudal type homeobox 2
CETP cholesteryl ester transfer protein, plasma
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CGA glycoprotein hormones, alpha polypeptide
CHEK2 checkpoint kinase 2
CHGA chromogranin A
CHGB chromogranin B
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHIT1 chitinase 1 (chitotriosidase)
CHM choroideremia (Rab escort protein 1)
CHMP2B charged multivesicular body protein 2B
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal)
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal)
CKB creatine kinase, brain
CLN8 ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation)
CLU clusterin
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
CNR1 cannabinoid receptor 1 (brain)
CNR2 cannabinoid receptor 2 (macrophage)
COL1A1 collagen, type I, alpha 1
COL4A1 collagen, type IV, alpha 1
COMP cartilage oligomeric matrix protein
COMT catechol-O-methyltransferase
CPA4 carboxypeptidase A4
CPB2 carboxypeptidase B2 (plasma)
CPLX2 complexin 2
CPT1A carnitine palmitoyltransferase 1A (liver)
CRP C-reactive protein, pentraxin-related
CRYGS crystallin, gamma S
CST3 cystatin C
CTGF connective tissue growth factor
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL9 chemokine (C-X-C motif) ligand 9
CYBA cytochrome b-245, alpha polypeptide
CYP11A1 cytochrome P450, family 11, subfamily A, polypeptide 1
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DEFB4A defensin, beta 4A
DICER1 dicer 1, ribonuclease type III
DLEC1 deleted in lung and esophageal cancer 1
DMPK dystrophia myotonica-protein kinase
DNM2 dynamin 2
DOK7 docking protein 7
DRD2 dopamine receptor D2
DRD4 dopamine receptor D4
DTNBP1 dystrobrevin binding protein 1
ECE1 endothelin converting enzyme 1
EGFR epidermal growth factor receptor
EIF5A2 eukaryotic translation initiation factor 5A2
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
EPO erythropoietin
ERAP1 endoplasmic reticulum aminopeptidase 1
ERAP2 endoplasmic reticulum aminopeptidase 2
ERBB2 erb-b2 receptor tyrosine kinase 2
ERCC1 excision repair cross-complementation group 1
ERCC2 excision repair cross-complementation group 2
ESR1 estrogen receptor 1
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
ETV6 ets variant 6
EZR ezrin
F11 coagulation factor XI
F12 coagulation factor XII (Hageman factor)
F2 coagulation factor II (thrombin)
F5 coagulation factor V (proaccelerin, labile factor)
F7 coagulation factor VII (serum prothrombin conversion accelerator)
F9 coagulation factor IX
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FASLG Fas ligand (TNF superfamily, member 6)
FBLN5 fibulin 5
FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
FEN1 flap structure-specific endonuclease 1
FGB fibrinogen beta chain
FGF21 fibroblast growth factor 21
FGF23 fibroblast growth factor 23
FLG filaggrin
FLT3 fms-related tyrosine kinase 3
FMR1 fragile X mental retardation 1
FOLR1 folate receptor 1 (adult)
FSHR follicle stimulating hormone receptor
FTO fat mass and obesity associated
FXN frataxin
G6PD glucose-6-phosphate dehydrogenase
GATA1 GATA binding protein 1 (globin transcription factor 1)
GCG glucagon
GCH1 GTP cyclohydrolase 1
GCK glucokinase (hexokinase 4)
GFAP glial fibrillary acidic protein
GHR growth hormone receptor
GHSR growth hormone secretagogue receptor
GIP gastric inhibitory polypeptide
GJB2 gap junction protein, beta 2, 26kDa
GLA galactosidase, alpha
GLUD1 glutamate dehydrogenase 1
GLUD2 glutamate dehydrogenase 2
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3
GP1BA glycoprotein Ib (platelet), alpha polypeptide
GPT glutamic-pyruvate transaminase (alanine aminotransferase)
GSTM1 glutathione S-transferase mu 1
GSTO2 glutathione S-transferase omega 2
GSTP1 glutathione S-transferase pi 1
GSTT1 glutathione S-transferase theta 1
GUCA1A guanylate cyclase activator 1A (retina)
HBA1 hemoglobin, alpha 1
HDAC2 histone deacetylase 2
HDAC3 histone deacetylase 3
HDAC5 histone deacetylase 5
HGD homogentisate 1,2-dioxygenase
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HHEX hematopoietically expressed homeobox
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HLA-F major histocompatibility complex, class I, F
HLA-G major histocompatibility complex, class I, G
HMOX1 heme oxygenase 1
HNF1A HNF1 homeobox A
HNF1B HNF1 homeobox B
HNF4A hepatocyte nuclear factor 4, alpha
HRAS Harvey rat sarcoma viral oncogene homolog
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
HTT huntingtin
ICAM1 intercellular adhesion molecule 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IDS iduronate 2-sulfatase
IFNG interferon, gamma
IFNL3 interferon, lambda 3
IGF1 insulin-like growth factor 1 (somatomedin C)
IGH immunoglobulin heavy locus
IL10 interleukin 10
IL10RA interleukin 10 receptor, alpha
IL10RB interleukin 10 receptor, beta
IL12A interleukin 12A
IL12B interleukin 12B
IL13 interleukin 13
IL15RA interleukin 15 receptor, alpha
IL18 interleukin 18
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL1RN interleukin 1 receptor antagonist
IL2 interleukin 2
IL23A interleukin 23, alpha subunit p19
IL5 interleukin 5
IL6 interleukin 6
IL6R interleukin 6 receptor
IL7 interleukin 7
INS insulin
INVS inversin
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
JAK2 Janus kinase 2
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
KCNJ11 potassium channel, inwardly rectifying subfamily J, member 11
KCNQ1 potassium channel, voltage gated KQT-like subfamily Q, member 1
KDR kinase insert domain receptor
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KL klotho
KLK3 kallikrein-related peptidase 3
KMT2A lysine (K)-specific methyltransferase 2A
KRAS Kirsten rat sarcoma viral oncogene homolog
LACRT lacritin
LCN2 lipocalin 2
LCT lactase
LEP leptin
LHCGR luteinizing hormone/choriogonadotropin receptor
LPL lipoprotein lipase
LRRK2 leucine-rich repeat kinase 2
LTBP2 latent transforming growth factor beta binding protein 2
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MAPT microtubule-associated protein tau
MBL2 mannose-binding lectin (protein C) 2, soluble
MC4R melanocortin 4 receptor
MCPH1 microcephalin 1
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MECOM MDS1 and EVI1 complex locus
MECP2 methyl CpG binding protein 2
MICA MHC class I polypeptide-related sequence A
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MIR196A2 microRNA 196a-2
MKI67 marker of proliferation Ki-67
MLH1 mutL homolog 1
MMP1 matrix metallopeptidase 1
MMP3 matrix metallopeptidase 3
MMP9 matrix metallopeptidase 9
MPO myeloperoxidase
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MSH2 mutS homolog 2
MSTN myostatin
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MUC16 mucin 16, cell surface associated
MUTYH mutY homolog
MYBPC3 myosin binding protein C, cardiac
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYO7A myosin VIIA
MYOG myogenin (myogenic factor 4)
NCAM1 neural cell adhesion molecule 1
NCOA3 nuclear receptor coactivator 3
NELFE negative elongation factor complex member E
NF1 neurofibromin 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NGFR nerve growth factor receptor
NLRP3 NLR family, pyrin domain containing 3
NME1 NME/NM23 nucleoside diphosphate kinase 1
NME2 NME/NM23 nucleoside diphosphate kinase 2
NOD1 nucleotide-binding oligomerization domain containing 1
NOD2 nucleotide-binding oligomerization domain containing 2
NOS3 nitric oxide synthase 3 (endothelial cell)
NPC1 Niemann-Pick disease, type C1
NPHP3 nephronophthisis 3 (adolescent)
NPPA natriuretic peptide A
NPPB natriuretic peptide B
NPY neuropeptide Y
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NR4A2 nuclear receptor subfamily 4, group A, member 2
NRG1 neuregulin 1
NRL neural retina leucine zipper
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUMB numb homolog (Drosophila)
OGG1 8-oxoguanine DNA glycosylase
OPRM1 opioid receptor, mu 1
PABPN1 poly(A) binding protein, nuclear 1
PAEP progestagen-associated endometrial protein
PARK2 parkin RBR E3 ubiquitin protein ligase
PARK7 parkinson protein 7
PARP1 poly (ADP-ribose) polymerase 1
PBRM1 polybromo 1
PDE4D phosphodiesterase 4D, cAMP-specific
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PITX2 paired-like homeodomain 2
PKD1 polycystic kidney disease 1 (autosomal dominant)
PKD2 polycystic kidney disease 2 (autosomal dominant)
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
POLG polymerase (DNA directed), gamma
PON1 paraoxonase 1
PPARG peroxisome proliferator-activated receptor gamma
PRDM16 PR domain containing 16
PRDX2 peroxiredoxin 2
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha
PRNP prion protein
PROC protein C (inactivator of coagulation factors Va and VIIIa)
PROS1 protein S (alpha)
PRPH2 peripherin 2 (retinal degeneration, slow)
PSEN1 presenilin 1
PSMD9 proteasome (prosome, macropain) 26S subunit, non-ATPase, 9
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTH parathyroid hormone
PTTG1 pituitary tumor-transforming 1
RBP4 retinol binding protein 4, plasma
REN renin
RET ret proto-oncogene
RGS4 regulator of G-protein signaling 4
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
RUNX1 runt-related transcription factor 1
S100B S100 calcium binding protein B
SCARB1 scavenger receptor class B, member 1
SCN5A sodium channel, voltage gated, type V alpha subunit
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
SELL selectin L
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SIRT1 sirtuin 1
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1
SMARCAL1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SOD1 superoxide dismutase 1, soluble
SOD2 superoxide dismutase 2, mitochondrial
SOX9 SRY (sex determining region Y)-box 9
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPP1 secreted phosphoprotein 1
SREBF1 sterol regulatory element binding transcription factor 1
STK11 serine/threonine kinase 11
SUFU suppressor of fused homolog (Drosophila)
TERC telomerase RNA component
TET2 tet methylcytosine dioxygenase 2
TF transferrin
TFF1 trefoil factor 1
TG thyroglobulin
TGFB1 transforming growth factor, beta 1
THBD thrombomodulin
TIMP1 TIMP metallopeptidase inhibitor 1
TIMP2 TIMP metallopeptidase inhibitor 2
TK2 thymidine kinase 2, mitochondrial
TLR1 toll-like receptor 1
TLR2 toll-like receptor 2
TLR3 toll-like receptor 3
TLR4 toll-like receptor 4
TLR6 toll-like receptor 6
TNC tenascin C
TNF tumor necrosis factor
TNFRSF8 tumor necrosis factor receptor superfamily, member 8
TOX3 TOX high mobility group box family member 3
TP53 tumor protein p53
TP63 tumor protein p63
TP73 tumor protein p73
TPH2 tryptophan hydroxylase 2
TRG T cell receptor gamma locus
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae)
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein
TSHB thyroid stimulating hormone, beta
TSLP thymic stromal lymphopoietin
TSPO translocator protein (18kDa)
TTR transthyretin
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UGT1A4 UDP glucuronosyltransferase 1 family, polypeptide A4
USP24 ubiquitin specific peptidase 24
USP40 ubiquitin specific peptidase 40
VCAM1 vascular cell adhesion molecule 1
VCP valosin containing protein
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFA vascular endothelial growth factor A
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
VIP vasoactive intestinal peptide
VKORC1 vitamin K epoxide reductase complex, subunit 1
VPS13B vacuolar protein sorting 13 homolog B (yeast)
VWF von Willebrand factor
WFDC2 WAP four-disulfide core domain 2
WFS1 Wolfram syndrome 1 (wolframin)
WNT16 wingless-type MMTV integration site family, member 16
WT1 Wilms tumor 1
WWC1 WW and C2 domain containing 1
XPC xeroderma pigmentosum, complementation group C
XPO1 exportin 1
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1