yohimbic acid-2147 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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195 genes differentially expressed following the yohimbic acid-2147 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AAMDC adipogenesis associated, Mth938 domain containing
ACSS3 acyl-CoA synthetase short-chain family member 3
APOBEC1 apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1
ARHGAP1 Rho GTPase activating protein 1
ATN1 atrophin 1
B9D2 B9 protein domain 2
C11ORF16 chromosome 11 open reading frame 16
C5ORF45 chromosome 5 open reading frame 45
CAMK4 calcium/calmodulin-dependent protein kinase IV
CD6 CD6 molecule
CDK16 cyclin-dependent kinase 16
CELP carboxyl ester lipase pseudogene
CFAP45 cilia and flagella associated protein 45
CHN2 chimerin 2
CLEC4A C-type lectin domain family 4, member A
CPNE7 copine VII
CSF2RA colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)
CSNK1G1 casein kinase 1, gamma 1
CYR61 cysteine-rich, angiogenic inducer, 61
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DPY19L1 dpy-19-like 1 (C. elegans)
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
E2F5 E2F transcription factor 5, p130-binding
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
ELAVL3 ELAV like neuron-specific RNA binding protein 3
FGFR1 fibroblast growth factor receptor 1
GALC galactosylceramidase
GFER growth factor, augmenter of liver regeneration
GJA9 gap junction protein, alpha 9, 59kDa
GK3P glycerol kinase 3 pseudogene
GOSR2 golgi SNAP receptor complex member 2
H2AFX H2A histone family, member X
HIF3A hypoxia inducible factor 3, alpha subunit
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker)
IQSEC1 IQ motif and Sec7 domain 1
ITCH itchy E3 ubiquitin protein ligase
KIAA0485 uncharacterized LOC57235
KIAA1456 KIAA1456
KRT81 keratin 81, type II
LAMA4 laminin, alpha 4
LECT1 leukocyte cell derived chemotaxin 1
LY6G5C lymphocyte antigen 6 complex, locus G5C
MAP7 microtubule-associated protein 7
MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3
MCAM melanoma cell adhesion molecule
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MFAP3 microfibrillar-associated protein 3
MTA1 metastasis associated 1
MXD3 MAX dimerization protein 3
NDE1 nudE neurodevelopment protein 1
NF2 neurofibromin 2 (merlin)
NIPAL2 NIPA-like domain containing 2
NNAT neuronatin
NRG2 neuregulin 2
NUMA1 nuclear mitotic apparatus protein 1
NUP50 nucleoporin 50kDa
OPTN optineurin
PADI4 peptidyl arginine deiminase, type IV
PCDHGA8 protocadherin gamma subfamily A, 8
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PEAK1 pseudopodium-enriched atypical kinase 1
PI4K2A phosphatidylinositol 4-kinase type 2 alpha
PICK1 protein interacting with PRKCA 1
PLSCR1 phospholipid scramblase 1
PTCH2 patched 2
PVRL1 poliovirus receptor-related 1 (herpesvirus entry mediator C)
RAB3A RAB3A, member RAS oncogene family
RECQL5 RecQ protein-like 5
REM1 RAS (RAD and GEM)-like GTP-binding 1
RFX2 regulatory factor X, 2 (influences HLA class II expression)
RGS19 regulator of G-protein signaling 19
RHBDF1 rhomboid 5 homolog 1 (Drosophila)
RNF126P1 ring finger protein 126 pseudogene 1
RNF25 ring finger protein 25
RRBP1 ribosome binding protein 1
RUSC2 RUN and SH3 domain containing 2
SEC61A2 Sec61 alpha 2 subunit (S. cerevisiae)
SEZ6L seizure related 6 homolog (mouse)-like
SLIT2 slit homolog 2 (Drosophila)
SPTB spectrin, beta, erythrocytic
SV2B synaptic vesicle glycoprotein 2B
SVEP1 sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
TAPT1 transmembrane anterior posterior transformation 1
TIAM1 T-cell lymphoma invasion and metastasis 1
TMEM63A transmembrane protein 63A
TRA T cell receptor alpha locus
TRAF1 TNF receptor-associated factor 1
TRAPPC9 trafficking protein particle complex 9
TRIM58 tripartite motif containing 58
TSC22D4 TSC22 domain family, member 4
TSPAN2 tetraspanin 2
TSPYL2 TSPY-like 2
TULP2 tubby like protein 2
UBR2 ubiquitin protein ligase E3 component n-recognin 2
WDFY3 WD repeat and FYVE domain containing 3
ZNF276 zinc finger protein 276
ZNF552 zinc finger protein 552

decreased expression

Symbol Name
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain
ACP6 acid phosphatase 6, lysophosphatidic
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ADTRP androgen-dependent TFPI-regulating protein
APH1B APH1B gamma secretase subunit
BBC3 BCL2 binding component 3
BCL2L2 BCL2-like 2
BNC2 basonuclin 2
C17ORF70 chromosome 17 open reading frame 70
C7ORF43 chromosome 7 open reading frame 43
CCL4 chemokine (C-C motif) ligand 4
CD3D CD3d molecule, delta (CD3-TCR complex)
CD69 CD69 molecule
CD82 CD82 molecule
CEP295 centrosomal protein 295kDa
CFP complement factor properdin
CLEC4E C-type lectin domain family 4, member E
COL15A1 collagen, type XV, alpha 1
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
DDX31 DEAD (Asp-Glu-Ala-Asp) box polypeptide 31
DEFB1 defensin, beta 1
DFNA5 deafness, autosomal dominant 5
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DOC2A double C2-like domains, alpha
DOK5 docking protein 5
DPY19L2P2 DPY19L2 pseudogene 2
DVL1 dishevelled segment polarity protein 1
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1
DZANK1 double zinc ribbon and ankyrin repeat domains 1
EDAR ectodysplasin A receptor
ELMO3 engulfment and cell motility 3
FAM63A family with sequence similarity 63, member A
FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64)
FUZ fuzzy planar cell polarity protein
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3
GNL3LP1 guanine nucleotide binding protein-like 3 (nucleolar)-like pseudogene 1
HIST1H1T histone cluster 1, H1t
HIST1H2BI histone cluster 1, H2bi
HIST1H4C histone cluster 1, H4c
IER3IP1 immediate early response 3 interacting protein 1
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2
KANSL1L KAT8 regulatory NSL complex subunit 1-like
KCNMB1 potassium channel subfamily M regulatory beta subunit 1
KCNMB4 potassium channel subfamily M regulatory beta subunit 4
KLHL21 kelch-like family member 21
KRT8P12 keratin 8 pseudogene 12
LY6G6C lymphocyte antigen 6 complex, locus G6C
MLPH melanophilin
MMP9 matrix metallopeptidase 9
MYL5 myosin, light chain 5, regulatory
MYO1E myosin IE
NPIPB15 nuclear pore complex interacting protein family, member B15
NPM3 nucleophosmin/nucleoplasmin 3
NXPE3 neurexophilin and PC-esterase domain family, member 3
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
OXTR oxytocin receptor
PADI1 peptidyl arginine deiminase, type I
PER3 period circadian clock 3
PHACTR1 phosphatase and actin regulator 1
PMCH pro-melanin-concentrating hormone
POM121L2 POM121 transmembrane nucleoporin-like 2
PPT2 palmitoyl-protein thioesterase 2
PRAMEF11 PRAME family member 11
PREX2 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
PRR4 proline rich 4 (lacrimal)
RAB17 RAB17, member RAS oncogene family
RETN resistin
RNF122 ring finger protein 122
RNF31 ring finger protein 31
RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2
RRAS related RAS viral (r-ras) oncogene homolog
SEMA3G sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G
SERGEF secretion regulating guanine nucleotide exchange factor
SLC15A3 solute carrier family 15 (oligopeptide transporter), member 3
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SNAI1 snail family zinc finger 1
TAGLN transgelin
TAOK1 TAO kinase 1
TMEM246 transmembrane protein 246
TMEM53 transmembrane protein 53
TRAC T cell receptor alpha constant
TRAF2 TNF receptor-associated factor 2
TRIM45 tripartite motif containing 45
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TSPAN32 tetraspanin 32
TUBA4B tubulin, alpha 4b
UBE2O ubiquitin-conjugating enzyme E2O
UPB1 ureidopropionase, beta
UPK3A uroplakin 3A
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae)
ZFAND3 zinc finger, AN1-type domain 3
ZNF32 zinc finger protein 32
ZNF749 zinc finger protein 749
ZNF8 zinc finger protein 8