z disc Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached. (Gene Ontology, GO_0030018)
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Genes

201 proteins co-occuring with the z disc cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
TTN titin 2.89721
NEB nebulin 2.27986
MYOT myotilin 2.15882
LDB3 LIM domain binding 3 2.02927
FLNC filamin C, gamma 1.8628
MYOZ1 myozenin 1 1.75147
OBSCN obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF 1.66962
TCAP titin-cap 1.64972
MYOZ2 myozenin 2 1.62059
ACTN2 actinin, alpha 2 1.61823
TPM1 tropomyosin 1 (alpha) 1.51243
NEBL nebulette 1.46665
MYPN myopalladin 1.46495
PDLIM3 PDZ and LIM domain 3 1.3896
CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein) 1.38405
VCL vinculin 1.37299
CRYAB crystallin, alpha B 1.3543
MYOM2 myomesin 2 1.34774
BAG3 BCL2-associated athanogene 3 1.34392
SYNM synemin, intermediate filament protein 1.25759
DMD dystrophin 1.21686
DES desmin 1.06954
TNNT2 troponin T type 2 (cardiac) 0.996123
TMOD4 tropomodulin 4 (muscle) 0.989759
PALLD palladin, cytoskeletal associated protein 0.956874
MB myoglobin 0.956874
MYOZ3 myozenin 3 0.934544
MURC muscle-related coiled-coil protein 0.874567
TPM2 tropomyosin 2 (beta) 0.855717
CMYA5 cardiomyopathy associated 5 0.85342
MYOG myogenin (myogenic factor 4) 0.829089
MYOD1 myogenic differentiation 1 0.793771
TRIM63 tripartite motif containing 63, E3 ubiquitin protein ligase 0.792396
PARVB parvin, beta 0.791939
GFAP glial fibrillary acidic protein 0.789191
OBSL1 obscurin-like 1 0.771819
CAPZA3 capping protein (actin filament) muscle Z-line, alpha 3 0.764982
MYH6 myosin, heavy chain 6, cardiac muscle, alpha 0.743671
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 0.736913
TRIM32 tripartite motif containing 32 0.735565
CTAG2 cancer/testis antigen 2 0.728836
TNNI3 troponin I type 3 (cardiac) 0.721242
ANK1 ankyrin 1, erythrocytic 0.713238
RYR1 ryanodine receptor 1 (skeletal) 0.710136
CAPZB capping protein (actin filament) muscle Z-line, beta 0.705273
FBXL22 F-box and leucine-rich repeat protein 22 0.703507
GSN gelsolin 0.697784
SYNPO2 synaptopodin 2 0.682463
TMBIM4 transmembrane BAX inhibitor motif containing 4 0.677673
ACTA1 actin, alpha 1, skeletal muscle 0.668126
PDLIM5 PDZ and LIM domain 5 0.665529
FHL2 four and a half LIM domains 2 0.664232
DNM2 dynamin 2 0.657326
CAPN3 calpain 3, (p94) 0.65259
DYSF dysferlin 0.647433
PDE5A phosphodiesterase 5A, cGMP-specific 0.623504
UNC45B unc-45 homolog B (C. elegans) 0.616709
LRRC39 leucine rich repeat containing 39 0.614589
NEXN nexilin (F actin binding protein) 0.579251
LIMS2 LIM and senescent cell antigen-like domains 2 0.577164
FN1 fibronectin 1 0.573411
LIMS3 LIM and senescent cell antigen-like domains 3 0.568001
LRRC10 leucine rich repeat containing 10 0.561358
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.558042
RBM24 RNA binding motif protein 24 0.555973
TPM3 tropomyosin 3 0.553905
CAST calpastatin 0.552251
DNAH8 dynein, axonemal, heavy chain 8 0.546472
CAV3 caveolin 3 0.539883
SORBS2 sorbin and SH3 domain containing 2 0.535772
MEF2A myocyte enhancer factor 2A 0.529618
FBP1 fructose-1,6-bisphosphatase 1 0.521841
RYR2 ryanodine receptor 2 (cardiac) 0.521023
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) 0.517348
RCAN1 regulator of calcineurin 1 0.514085
HSPB2 heat shock 27kDa protein 2 0.512862
ATP12A ATPase, H+/K+ transporting, nongastric, alpha polypeptide 0.510418
AHNAK2 AHNAK nucleoprotein 2 0.510011
ATP4A ATPase, H+/K+ exchanging, alpha polypeptide 0.509197
JPH2 junctophilin 2 0.505131
MYH1 myosin, heavy chain 1, skeletal muscle, adult 0.487711
CASQ1 calsequestrin 1 (fast-twitch, skeletal muscle) 0.469203
FLNA filamin A, alpha 0.466799
CASQ2 calsequestrin 2 (cardiac muscle) 0.465198
NPPA natriuretic peptide A 0.460401
TMOD1 tropomodulin 1 0.460001
GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase 0.457606
SRF serum response factor (c-fos serum response element-binding transcription factor) 0.456012
MYBPC1 myosin binding protein C, slow type 0.455214
LMCD1 LIM and cysteine-rich domains 1 0.447656
MYL1 myosin, light chain 1, alkali; skeletal, fast 0.445275
QDPR quinoid dihydropteridine reductase 0.433801
PYGB phosphorylase, glycogen; brain 0.427891
SEPN1 selenoprotein N, 1 0.427497
PYGL phosphorylase, glycogen, liver 0.427497
MYH7 myosin, heavy chain 7, cardiac muscle, beta 0.426711
PYGM phosphorylase, glycogen, muscle 0.425531
ACTG1 actin gamma 1 0.406361
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle) 0.402859
ZYX zyxin 0.400916
GMEB1 glucocorticoid modulatory element binding protein 1 0.399363
ILK integrin-linked kinase 0.397035
CSN1S1 casein alpha s1 0.390068
USP13 ubiquitin specific peptidase 13 (isopeptidase T-3) 0.388523
CSNK1A1 casein kinase 1, alpha 1 0.386593
ACTN1 actinin, alpha 1 0.386593
STAC3 SH3 and cysteine rich domain 3 0.385822
FHL1 four and a half LIM domains 1 0.385436
KCNE5 potassium channel, voltage gated subfamily E regulatory beta subunit 5 0.383124
CAPN2 calpain 2, (m/II) large subunit 0.382354
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1 0.378507
CCR10 chemokine (C-C motif) receptor 10 0.374283
MEX3D mex-3 RNA binding family member D 0.368153
SCN4A sodium channel, voltage gated, type IV alpha subunit 0.367771
NRAP nebulin-related anchoring protein 0.366623
CACNA1S calcium channel, voltage-dependent, L type, alpha 1S subunit 0.366241
CALM3 calmodulin 3 (phosphorylase kinase, delta) 0.355183
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.354802
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.354802
MYOM3 myomesin 3 0.353282
FPGT fucose-1-phosphate guanylyltransferase 0.349863
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 0.345692
RBM20 RNA binding motif protein 20 0.345314
TRIM54 tripartite motif containing 54 0.324951
MYL2 myosin, light chain 2, regulatory, cardiac, slow 0.324201
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1 0.32345
GATA4 GATA binding protein 4 0.318953
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4 0.317082
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 0.309986
PDLIM1 PDZ and LIM domain 1 0.304399
MYF5 myogenic factor 5 0.302168
ZRANB2 zinc finger, RAN-binding domain containing 2 0.301425
MYBPC3 myosin binding protein C, cardiac 0.297342
MPV17L MPV17 mitochondrial membrane protein-like 0.29586
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein 0.293267
CFL2 cofilin 2 (muscle) 0.291047
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 0.288091
NES nestin 0.288091
PDLIM2 PDZ and LIM domain 2 (mystique) 0.285507
CTSS cathepsin S 0.285138
CNBP CCHC-type zinc finger, nucleic acid binding protein 0.284401
SRC SRC proto-oncogene, non-receptor tyrosine kinase 0.281821
AKAP7 A kinase (PRKA) anchor protein 7 0.278509
MGAM maltase-glucoamylase 0.271167
ACHE acetylcholinesterase (Yt blood group) 0.267871
PDE4DIP phosphodiesterase 4D interacting protein 0.267505
MYO18B myosin XVIIIB 0.267139
AHNAK AHNAK nucleoprotein 0.265311
ANXA6 annexin A6 0.259109
LIM2 lens intrinsic membrane protein 2, 19kDa 0.255107
SRI sorcin 0.253291
RTN2 reticulon 2 0.250751
GPR1 G protein-coupled receptor 1 0.247854
GJA1 gap junction protein, alpha 1, 43kDa 0.246407
SPTBN1 spectrin, beta, non-erythrocytic 1 0.246046
OR10T2 olfactory receptor, family 10, subfamily T, member 2 0.245685
YIPF1 Yip1 domain family, member 1 0.243158
BMP10 bone morphogenetic protein 10 0.241716
FKTN fukutin 0.239916
XIRP1 xin actin binding repeat containing 1 0.238478
CALD1 caldesmon 1 0.238478
CDH2 cadherin 2, type 1, N-cadherin (neuronal) 0.237042
PAX7 paired box 7 0.236683
TRIM55 tripartite motif containing 55 0.231315
COPB2 coatomer protein complex, subunit beta 2 (beta prime) 0.230958
PGM5 phosphoglucomutase 5 0.229176
RAVER1 ribonucleoprotein, PTB-binding 1 0.228464
XIRP2 xin actin binding repeat containing 2 0.226331
MMP28 matrix metallopeptidase 28 0.225976
TNNT1 troponin T type 1 (skeletal, slow) 0.220321
MIR22 microRNA 22 0.218212
PRKD1 protein kinase D1 0.213322
MSTN myostatin 0.208481
BCHE butyrylcholinesterase 0.204718
PKLR pyruvate kinase, liver and RBC 0.204039
DST dystonin 0.198658
GNB2L1 guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 0.198325
SIVA1 SIVA1, apoptosis-inducing factor 0.197993
S100A1 S100 calcium binding protein A1 0.194698
ZFPM1 zinc finger protein, FOG family member 1 0.194045
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1) 0.193394
MYEF2 myelin expression factor 2 0.191135
GLE1 GLE1 RNA export mediator 0.18702
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 0.186087
FMN1 formin 1 0.183935
TMOD3 tropomodulin 3 (ubiquitous) 0.183025
FTL ferritin, light polypeptide 0.181227
FTH1 ferritin, heavy polypeptide 1 0.179752
SPEG SPEG complex locus 0.178588
PKM pyruvate kinase, muscle 0.175188
HSPB8 heat shock 22kDa protein 8 0.174361
MYF6 myogenic factor 6 (herculin) 0.17141
SCN2A sodium channel, voltage gated, type II alpha subunit 0.168101
SPTB spectrin, beta, erythrocytic 0.166884
ENO2 enolase 2 (gamma, neuronal) 0.16233
RANBP9 RAN binding protein 9 0.162117
DMPK dystrophia myotonica-protein kinase 0.161693
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 0.159658
INHBA inhibin, beta A 0.159268
PPP3CB protein phosphatase 3, catalytic subunit, beta isozyme 0.157943
MYO18A myosin XVIIIA 0.156863