zap70 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description zeta-chain (TCR) associated protein kinase 70kDa|This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 7535)
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Genes

50 genes co-occuring with the biological term zap70 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ADAM29 ADAM metallopeptidase domain 29
AKT1 v-akt murine thymoma viral oncogene homolog 1
BCL2 B-cell CLL/lymphoma 2
BRCA1 breast cancer 1, early onset
CD247 CD247 molecule
CD28 CD28 molecule
CD38 CD38 molecule
CD46 CD46 molecule, complement regulatory protein
CD69 CD69 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CDC25A cell division cycle 25A
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CXCL12 chemokine (C-X-C motif) ligand 12
CXCR4 chemokine (C-X-C motif) receptor 4
DNMT1 DNA (cytosine-5-)-methyltransferase 1
DUSP3 dual specificity phosphatase 3
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
IGH immunoglobulin heavy locus
LAG3 lymphocyte-activation gene 3
LAT linker for activation of T cells
LCK LCK proto-oncogene, Src family tyrosine kinase
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
LPL lipoprotein lipase
MCL1 myeloid cell leukemia 1
MIR126 microRNA 126
MIR365A microRNA 365a
NOTCH1 notch 1
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PLCG1 phospholipase C, gamma 1
PRKCB protein kinase C, beta
PTPN6 protein tyrosine phosphatase, non-receptor type 6
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RPSA ribosomal protein SA
SF3B1 splicing factor 3b, subunit 1, 155kDa
SH2D2A SH2 domain containing 2A
SLC7A4 solute carrier family 7, member 4
SPN sialophorin
SYK spleen tyrosine kinase
TFRC transferrin receptor
TLN1 talin 1
TLR9 toll-like receptor 9
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TP53 tumor protein p53
TP73 tumor protein p73
VAV1 vav 1 guanine nucleotide exchange factor
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa