zaprinast-5349 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the zaprinast-5349 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ACOT11 acyl-CoA thioesterase 11
ACTN2 actinin, alpha 2
AP1S2 adaptor-related protein complex 1, sigma 2 subunit
AP2A2 adaptor-related protein complex 2, alpha 2 subunit
ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
ARFRP1 ADP-ribosylation factor related protein 1
ATP2A3 ATPase, Ca++ transporting, ubiquitous
B4GALT7 xylosylprotein beta 1,4-galactosyltransferase, polypeptide 7
C6ORF47 chromosome 6 open reading frame 47
CAPN5 calpain 5
CDC14A cell division cycle 14A
CDC14B cell division cycle 14B
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CDKN2A cyclin-dependent kinase inhibitor 2A
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEP152 centrosomal protein 152kDa
CNPY4 canopy FGF signaling regulator 4
COBLL1 cordon-bleu WH2 repeat protein-like 1
COL6A1 collagen, type VI, alpha 1
CPTP ceramide-1-phosphate transfer protein
CTC1 CTS telomere maintenance complex component 1
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DGCR11 DiGeorge syndrome critical region gene 11 (non-protein coding)
DIO2 deiodinase, iodothyronine, type II
ELOVL5 ELOVL fatty acid elongase 5
ELSPBP1 epididymal sperm binding protein 1
EMC1 ER membrane protein complex subunit 1
ERN2 endoplasmic reticulum to nucleus signaling 2
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FKBP14 FK506 binding protein 14, 22 kDa
FLJ11292
FOXO1 forkhead box O1
FZD7 frizzled class receptor 7
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
GIT2 G protein-coupled receptor kinase interacting ArfGAP 2
GPRIN2 G protein regulated inducer of neurite outgrowth 2
HFE hemochromatosis
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)
HPS1 Hermansky-Pudlak syndrome 1
HPS4 Hermansky-Pudlak syndrome 4
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
IL17RA interleukin 17 receptor A
INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa
KCNJ3 potassium channel, inwardly rectifying subfamily J, member 3
LRRC20 leucine rich repeat containing 20
LZTS3 leucine zipper, putative tumor suppressor family member 3
MAP1B microtubule-associated protein 1B
MED16 mediator complex subunit 16
MFNG MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
MITF microphthalmia-associated transcription factor
MVP major vault protein
MXD4 MAX dimerization protein 4
NADK NAD kinase
NIPAL2 NIPA-like domain containing 2
NMT2 N-myristoyltransferase 2
OGFOD2 2-oxoglutarate and iron-dependent oxygenase domain containing 2
OR7E156P olfactory receptor, family 7, subfamily E, member 156 pseudogene
OSMR oncostatin M receptor
PCDH12 protocadherin 12
PCGF2 polycomb group ring finger 2
PLCG1 phospholipase C, gamma 1
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PRR4 proline rich 4 (lacrimal)
PRRG2 proline rich Gla (G-carboxyglutamic acid) 2
PTCRA pre T-cell antigen receptor alpha
PTMS parathymosin
QKI QKI, KH domain containing, RNA binding
RAB6A RAB6A, member RAS oncogene family
RECQL5 RecQ protein-like 5
RPL10L ribosomal protein L10-like
SAFB2 scaffold attachment factor B2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SFTPC surfactant protein C
SH2B1 SH2B adaptor protein 1
SH3BP2 SH3-domain binding protein 2
SIDT2 SID1 transmembrane family, member 2
SLC16A5 solute carrier family 16 (monocarboxylate transporter), member 5
SLC30A5 solute carrier family 30 (zinc transporter), member 5
SLC35D1 solute carrier family 35 (UDP-GlcA/UDP-GalNAc transporter), member D1
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SND1-IT1 SND1 intronic transcript 1
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa
TAZ tafazzin
TCF7 transcription factor 7 (T-cell specific, HMG-box)
TLDC1 TBC/LysM-associated domain containing 1
TMEM104 transmembrane protein 104
TMEM242 transmembrane protein 242
TP53I11 tumor protein p53 inducible protein 11
TRPV1 transient receptor potential cation channel, subfamily V, member 1
U2AF2 U2 small nuclear RNA auxiliary factor 2
UBXN1 UBX domain protein 1
WSB1 WD repeat and SOCS box containing 1
ZKSCAN5 zinc finger with KRAB and SCAN domains 5
ZNF318 zinc finger protein 318
ZNF589 zinc finger protein 589
ZNF76 zinc finger protein 76

decreased expression

Symbol Name
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6
AEN apoptosis enhancing nuclease
AFF4 AF4/FMR2 family, member 4
AMDHD2 amidohydrolase domain containing 2
ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A
ANXA2P3 annexin A2 pseudogene 3
AP1G2 adaptor-related protein complex 1, gamma 2 subunit
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26
ARNTL2 aryl hydrocarbon receptor nuclear translocator-like 2
BPGM 2,3-bisphosphoglycerate mutase
CEP85 centrosomal protein 85kDa
CEP97 centrosomal protein 97kDa
CHST12 carbohydrate (chondroitin 4) sulfotransferase 12
CLDND1 claudin domain containing 1
CLEC16A C-type lectin domain family 16, member A
CLSTN1 calsyntenin 1
CRELD1 cysteine-rich with EGF-like domains 1
CYB5R1 cytochrome b5 reductase 1
CYB5R4 cytochrome b5 reductase 4
DDX43 DEAD (Asp-Glu-Ala-Asp) box polypeptide 43
DHRS11 dehydrogenase/reductase (SDR family) member 11
DNAAF2 dynein, axonemal, assembly factor 2
DTWD1 DTW domain containing 1
ERH enhancer of rudimentary homolog (Drosophila)
F3 coagulation factor III (thromboplastin, tissue factor)
FAM179B family with sequence similarity 179, member B
FAM86C1 family with sequence similarity 86, member C1
FKBP10 FK506 binding protein 10, 65 kDa
FSD1 fibronectin type III and SPRY domain containing 1
GHR growth hormone receptor
GUF1 GUF1 GTPase homolog (S. cerevisiae)
H1F0 H1 histone family, member 0
HIST1H1D histone cluster 1, H1d
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HP1BP3 heterochromatin protein 1, binding protein 3
IFI6 interferon, alpha-inducible protein 6
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1)
IMPACT impact RWD domain protein
KIF4A kinesin family member 4A
KLF10 Kruppel-like factor 10
LIG4 ligase IV, DNA, ATP-dependent
LINC00115 long intergenic non-protein coding RNA 115
LMNB1 lamin B1
LOC202181 SUMO-interacting motifs containing 1 pseudogene
LRRC8E leucine rich repeat containing 8 family, member E
LY6D lymphocyte antigen 6 complex, locus D
MCOLN3 mucolipin 3
MIS12 MIS12 kinetochore complex component
MKNK2 MAP kinase interacting serine/threonine kinase 2
MPDU1 mannose-P-dolichol utilization defect 1
MTG1 mitochondrial ribosome-associated GTPase 1
MTMR12 myotubularin related protein 12
MYBBP1A MYB binding protein (P160) 1a
NDE1 nudE neurodevelopment protein 1
NDUFAF7 NADH dehydrogenase (ubiquinone) complex I, assembly factor 7
NPL N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)
NPM3 nucleophosmin/nucleoplasmin 3
NT5C 5', 3'-nucleotidase, cytosolic
NUP85 nucleoporin 85kDa
NUPL2 nucleoporin like 2
NVL nuclear VCP-like
ODF2 outer dense fiber of sperm tails 2
PCSK7 proprotein convertase subtilisin/kexin type 7
PDLIM2 PDZ and LIM domain 2 (mystique)
PIGT phosphatidylinositol glycan anchor biosynthesis, class T
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PTTG3P pituitary tumor-transforming 3, pseudogene
PUS7L pseudouridylate synthase 7 homolog (S. cerevisiae)-like
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
RNF121 ring finger protein 121
RP2 retinitis pigmentosa 2 (X-linked recessive)
SCYL2 SCY1-like 2 (S. cerevisiae)
SETD8 SET domain containing (lysine methyltransferase) 8
SIRAL2 SIR2 antiphage like 2
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5
STK16 serine/threonine kinase 16
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1
SUV39H2 suppressor of variegation 3-9 homolog 2 (Drosophila)
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
THG1L tRNA-histidine guanylyltransferase 1-like (S. cerevisiae)
THNSL1 threonine synthase-like 1 (S. cerevisiae)
THOP1 thimet oligopeptidase 1
TIGAR TP53 induced glycolysis regulatory phosphatase
TMEM185B transmembrane protein 185B
TMEM57 transmembrane protein 57
TPST2 tyrosylprotein sulfotransferase 2
TRMT11 tRNA methyltransferase 11 homolog (S. cerevisiae)
TRMU tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
TXLNG taxilin gamma
TYW1 tRNA-yW synthesizing protein 1 homolog (S. cerevisiae)
UEVLD UEV and lactate/malate dehyrogenase domains
VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae)
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing
ZFP69B ZFP69 zinc finger protein B
ZNF134 zinc finger protein 134
ZNF254 zinc finger protein 254
ZNF302 zinc finger protein 302
ZNF324 zinc finger protein 324
ZNF365 zinc finger protein 365
ZNF675 zinc finger protein 675