For this case study, we trained a Random Forest classifier to distinguish between ion channels and other transmembrane proteins, and then applied the classifier to predict if any uncharacterized transmembrane proteins might be ion channels. The classifier performed very well in cross-validation with an area under the receiver operating characteristic curve of 0.99, F1-score of 0.922, and Matthew’s correlation coefficient of 0.918. Methods and results for this machine learning case study are described in detail in the Harmonizome publication.
Each row in the results table provides the gene symbol of a transmembrane protein (Gene column), provides the predicted probability that the protein is an ion channel (Probability column), indicates whether the protein is a known ion channel (Known column), indicates whether the protein was used as an example for training the classifier (Training column), provides the predicted false discovery rate if all predictions with better or equivalent probability were tested (FDR column), and lists up to two ion channels that the classifier thinks are most similar to the protein (Similar IC columns).
The table below shows predictions with probabilities greater than or equal to 0.5. To download the full table:
Gene | Probability | Known | Training | FDR | 1st Similar IC | 2nd Similar IC |
---|---|---|---|---|---|---|
CACNG7 | 1.0 | true | true | 0.0 | CACNG5, 0.99904 | CACNG8, 0.99889 |
CATSPER1 | 1.0 | true | true | 0.0 | CATSPER2, 0.97331 | HVCN1, 0.94631 |
CHRFAM7A | 1.0 | true | true | 0.0 | HTR3C, 0.99949 | HTR3E, 0.99941 |
CHRNA10 | 1.0 | true | true | 0.0 | CHRNG, 0.99929 | CHRNB3, 0.99908 |
CHRNA2 | 1.0 | true | true | 0.0 | CHRNG, 0.99854 | CHRNB3, 0.99806 |
CHRNB3 | 1.0 | true | true | 0.0 | CHRNA10, 0.99908 | CHRFAM7A, 0.99902 |
GABRA1 | 1.0 | true | true | 0.0 | GABRA4, 0.99559 | GABRA2, 0.99538 |
GABRA3 | 1.0 | true | true | 0.0 | GABRR1, 0.99897 | GABRA6, 0.99854 |
GABRA4 | 1.0 | true | true | 0.0 | GABRA2, 0.99926 | GABRB2, 0.99772 |
GABRA6 | 1.0 | true | true | 0.0 | GABRR1, 0.99954 | CHRFAM7A, 0.99909 |
GABRB2 | 1.0 | true | true | 0.0 | GABRA4, 0.99772 | GABRB3, 0.99772 |
GABRB3 | 1.0 | true | true | 0.0 | GABRB2, 0.99772 | GABRA4, 0.99625 |
GABRG1 | 1.0 | true | true | 0.0 | GABRG2, 0.99682 | GABRG3, 0.99679 |
GABRG2 | 1.0 | true | true | 0.0 | GABRG1, 0.99682 | GABRG3, 0.99382 |
GABRQ | 1.0 | true | true | 0.0 | GABRA3, 0.99829 | CHRNA3, 0.99808 |
GABRR2 | 1.0 | true | true | 0.0 | GABRR3, 0.99931 | GABRR1, 0.99919 |
GRID1 | 1.0 | true | true | 0.0 | GRID2, 0.996 | GRIK1, 0.99395 |
GRIK4 | 1.0 | true | true | 0.0 | GRIN2C, 0.99526 | GRIA4, 0.99422 |
HTR3E | 1.0 | true | true | 0.0 | HTR3C, 0.99966 | CHRFAM7A, 0.99941 |
KCNA1 | 1.0 | true | true | 0.0 | KCNA6, 0.99945 | KCNA3, 0.9985 |
KCNA5 | 1.0 | true | true | 0.0 | KCNA4, 0.99846 | KCNA6, 0.99807 |
KCNA6 | 1.0 | true | true | 0.0 | KCNA1, 0.99945 | KCNA3, 0.99828 |
KCNA7 | 1.0 | true | true | 0.0 | KCNA5, 0.99799 | KCND1, 0.99796 |
KCNH4 | 1.0 | true | true | 0.0 | KCNH8, 0.99523 | KCNH3, 0.99414 |
KCNH5 | 1.0 | true | true | 0.0 | KCNH7, 0.99446 | KCNH3, 0.9911 |
KCNH8 | 1.0 | true | true | 0.0 | KCNH3, 0.99597 | KCNH4, 0.99523 |
KCNJ3 | 1.0 | true | true | 0.0 | KCNJ5, 0.99853 | KCNJ12, 0.99753 |
KCNJ4 | 1.0 | true | true | 0.0 | KCNJ5, 0.99785 | KCNJ12, 0.99784 |
KCNJ5 | 1.0 | true | true | 0.0 | KCNJ12, 0.99923 | KCNJ10, 0.99894 |
KCNJ6 | 1.0 | true | true | 0.0 | KCNJ3, 0.99645 | KCNJ4, 0.99607 |
KCNJ9 | 1.0 | true | true | 0.0 | KCNJ16, 0.99912 | KCNJ1, 0.99898 |
KCNS1 | 1.0 | true | true | 0.0 | KCNG4, 0.99909 | KCNF1, 0.99839 |
KCNV1 | 1.0 | true | true | 0.0 | KCNG1, 0.99846 | KCND2, 0.99754 |
NALCN | 1.0 | true | true | 0.0 | TPCN2, 0.95354 | HVCN1, 0.95342 |
SCN1A | 1.0 | true | true | 0.0 | SCN2A, 0.99584 | SCN3A, 0.99295 |
TRPC3 | 1.0 | true | true | 0.0 | TRPC4, 0.99557 | TRPC6, 0.99146 |
TRPC4 | 1.0 | true | true | 0.0 | TRPC6, 0.9958 | TRPC3, 0.99557 |
TRPC6 | 1.0 | true | true | 0.0 | TRPC5, 0.99794 | TRPC4, 0.9958 |
TRPC7 | 1.0 | true | true | 0.0 | TRPC5, 0.99433 | TRPC6, 0.99132 |
CHRNA7 | 1.0 | false | true | 0.03 | CHRNB4, 0.99647 | GABRB2, 0.99625 |
GRIA1 | 0.99 | true | true | 0.02 | GRIN2B, 0.99609 | GRIA4, 0.99576 |
GLRA2 | 0.99 | true | true | 0.02 | GLRA1, 0.99518 | GLRA3, 0.99404 |
SCN8A | 0.99 | true | true | 0.02 | SCN5A, 0.99649 | SCN9A, 0.9955 |
CHRNB2 | 0.99 | true | true | 0.02 | GABRD, 0.99701 | CHRNB4, 0.99613 |
KCNJ15 | 0.99 | true | true | 0.02 | KCNJ16, 0.99932 | KCNJ9, 0.99854 |
GLRA3 | 0.99 | true | true | 0.02 | GLRA1, 0.99505 | GLRA2, 0.99404 |
KCNJ10 | 0.99 | true | true | 0.02 | KCNJ12, 0.99907 | KCNJ5, 0.99894 |
CACNA1D | 0.99 | true | true | 0.02 | CACNA1C, 0.99592 | CACNA1S, 0.98301 |
KCNG1 | 0.99 | true | true | 0.02 | KCNV1, 0.99846 | KCND3, 0.99716 |
SCNN1G | 0.99 | true | true | 0.02 | ASIC1, 0.99913 | SCNN1B, 0.99842 |
TPCN2 | 0.99 | true | true | 0.02 | TPCN1, 0.97525 | HVCN1, 0.9657 |
CACNG5 | 0.99 | true | true | 0.02 | CACNG1, 0.99983 | CACNG8, 0.99908 |
CLCN2 | 0.99 | true | true | 0.02 | CLCN6, 0.99826 | CLCN7, 0.998 |
KCNH3 | 0.99 | true | true | 0.02 | KCNH1, 0.99613 | KCNH8, 0.99597 |
KCNQ2 | 0.99 | true | true | 0.02 | KCNQ1, 0.99357 | KCNQ4, 0.99014 |
GABRR1 | 0.99 | true | true | 0.02 | GABRA6, 0.99954 | GABRR3, 0.99948 |
KCNC2 | 0.99 | true | true | 0.02 | KCNC1, 0.99808 | KCND3, 0.99802 |
CHRNA3 | 0.99 | true | true | 0.02 | CHRNB4, 0.99888 | GABRQ, 0.99808 |
CACNA1F | 0.99 | true | true | 0.02 | CACNA1S, 0.98826 | CACNA1C, 0.983 |
GRIA4 | 0.99 | true | true | 0.02 | GRIN2C, 0.99763 | GRIN2B, 0.9967 |
KCNG2 | 0.99 | true | true | 0.02 | KCNV1, 0.99726 | KCNG1, 0.99714 |
KCNG4 | 0.99 | true | true | 0.02 | KCNS1, 0.99909 | KCNV2, 0.99854 |
GABRD | 0.99 | true | true | 0.02 | CHRNB2, 0.99701 | GABRB3, 0.99619 |
KCNF1 | 0.99 | true | true | 0.02 | KCNS3, 0.9993 | KCNG3, 0.99888 |
TRPC5 | 0.99 | true | true | 0.02 | TRPC6, 0.99794 | TRPC7, 0.99433 |
CACNG2 | 0.99 | true | true | 0.01 | CACNG6, 0.9975 | CACNG3, 0.99749 |
GLRA1 | 0.99 | true | true | 0.02 | GLRA2, 0.99518 | GLRA3, 0.99505 |
KCNC1 | 0.99 | true | true | 0.01 | KCNC2, 0.99808 | KCND2, 0.99776 |
CATSPER2 | 0.99 | true | true | 0.01 | CATSPER1, 0.97331 | TPCN2, 0.94788 |
KCNJ1 | 0.99 | true | true | 0.01 | KCNJ16, 0.99935 | KCNJ13, 0.99915 |
GRIK2 | 0.98 | true | true | 0.01 | GRIA3, 0.99624 | GRIK1, 0.99608 |
GRIK3 | 0.98 | true | true | 0.01 | GRIN2C, 0.9969 | GRIN2B, 0.99687 |
SCN2A | 0.98 | true | true | 0.01 | SCN3A, 0.99714 | SCN1A, 0.99584 |
CHRNG | 0.98 | true | true | 0.01 | CHRNA10, 0.99929 | CHRNB3, 0.99888 |
SCN11A | 0.98 | true | true | 0.01 | SCN10A, 0.993 | SCN7A, 0.97608 |
CLCN1 | 0.98 | true | true | 0.01 | CLCNKA, 0.99952 | CLCNKB, 0.99925 |
KCNS3 | 0.98 | true | true | 0.01 | KCNF1, 0.9993 | KCNG3, 0.99881 |
CHRNA6 | 0.98 | true | true | 0.01 | CHRFAM7A, 0.99836 | CHRNB3, 0.99814 |
KCNS2 | 0.98 | true | true | 0.01 | KCNB1, 0.99724 | KCNS3, 0.99723 |
GRIN2B | 0.98 | true | true | 0.01 | GRIN2C, 0.99769 | GRIA3, 0.99694 |
CACNG4 | 0.98 | true | true | 0.01 | CACNG2, 0.99582 | CACNG6, 0.99546 |
SCN5A | 0.98 | true | true | 0.01 | SCN8A, 0.99649 | SCN9A, 0.99348 |
KCNJ16 | 0.98 | true | true | 0.01 | KCNJ1, 0.99935 | KCNJ15, 0.99932 |
HTR3C | 0.98 | true | true | 0.01 | HTR3E, 0.99966 | CHRFAM7A, 0.99949 |
CLCN3 | 0.98 | true | true | 0.01 | CLCN6, 0.99719 | CLCN2, 0.99699 |
CACNG8 | 0.98 | true | true | 0.01 | CACNG6, 0.99948 | CACNG1, 0.99924 |
KCNC4 | 0.98 | true | true | 0.01 | KCNA3, 0.99847 | KCNA1, 0.99842 |
CLCN5 | 0.98 | true | true | 0.01 | CLCN4, 0.99887 | CLCN7, 0.99868 |
CACNG1 | 0.98 | true | true | 0.01 | CACNG5, 0.99983 | CACNG8, 0.99924 |
KCNA2 | 0.98 | true | true | 0.01 | KCNA1, 0.99781 | KCNA6, 0.99774 |
CNGA4 | 0.98 | true | true | 0.01 | CNGA1, 0.99733 | CNGA2, 0.99654 |
CACNG6 | 0.98 | true | true | 0.01 | CACNG8, 0.99948 | CACNG1, 0.99891 |
CACNA1S | 0.98 | true | true | 0.01 | CACNA1C, 0.99024 | CACNA1F, 0.98826 |
KCNJ11 | 0.98 | true | true | 0.01 | KCNJ12, 0.99801 | KCNJ8, 0.99746 |
KCNA4 | 0.98 | true | true | 0.01 | KCNA5, 0.99846 | KCNA6, 0.99784 |
CACNA1C | 0.98 | true | true | 0.01 | CACNA1D, 0.99592 | CACNA1S, 0.99024 |
KCNH1 | 0.98 | true | true | 0.01 | KCNH3, 0.99613 | KCNH8, 0.9942 |
CNGA2 | 0.98 | true | true | 0.01 | CNGA1, 0.99819 | CNGA4, 0.99654 |
SCN4A | 0.97 | true | true | 0.01 | SCN7A, 0.9972 | SCN1A, 0.99254 |
KCNK12 | 0.97 | true | true | 0.01 | KCNK13, 0.99607 | KCNK4, 0.99425 |
KCNA3 | 0.97 | true | true | 0.01 | KCNA1, 0.9985 | KCNC4, 0.99847 |
SCN10A | 0.97 | true | true | 0.01 | SCN11A, 0.993 | SCN7A, 0.97464 |
CACNA2D2 | 0.97 | true | true | 0.01 | CACNA2D1, 0.99507 | CACNA2D4, 0.99427 |
HCN1 | 0.97 | true | true | 0.01 | HCN4, 0.9915 | HCN2, 0.98887 |
KCNH6 | 0.97 | true | true | 0.01 | KCNH3, 0.99358 | KCNH7, 0.99338 |
CLIC6 | 0.97 | true | true | 0.01 | CLIC5, 0.991 | CLIC3, 0.98903 |
KCNK13 | 0.97 | true | true | 0.01 | KCNK15, 0.99683 | KCNK12, 0.99607 |
ASIC3 | 0.97 | true | true | 0.01 | SCNN1D, 0.9996 | SCNN1B, 0.99912 |
KCNN2 | 0.97 | true | true | 0.01 | KCNK13, 0.99381 | KCNK9, 0.99285 |
GRIK5 | 0.97 | true | true | 0.01 | GRIN2D, 0.9931 | GRIK4, 0.99157 |
CNGA1 | 0.97 | true | true | 0.01 | CNGA2, 0.99819 | CNGA4, 0.99733 |
CACNA1A | 0.97 | true | true | 0.01 | CACNA1B, 0.96007 | CACNA1E, 0.95304 |
GABRR3 | 0.97 | true | true | 0.01 | GABRR1, 0.99948 | HTR3C, 0.99942 |
GRIK1 | 0.97 | true | true | 0.01 | GRID2, 0.99893 | GRIK2, 0.99608 |
KCNB1 | 0.97 | true | true | 0.01 | KCNS2, 0.99724 | KCNG3, 0.99622 |
KCNG3 | 0.97 | true | true | 0.01 | KCNF1, 0.99888 | KCNS3, 0.99881 |
GRIA2 | 0.97 | true | true | 0.01 | GRIA1, 0.99272 | GRID2, 0.99191 |
KCNJ8 | 0.97 | true | true | 0.01 | KCNJ12, 0.99812 | KCNJ5, 0.99774 |
KCNQ1 | 0.97 | true | true | 0.01 | KCNQ2, 0.99357 | KCNQ4, 0.98715 |
KCNJ12 | 0.97 | true | true | 0.01 | KCNJ5, 0.99923 | KCNJ10, 0.99907 |
KCNJ13 | 0.97 | true | true | 0.01 | KCNJ14, 0.99942 | KCNJ1, 0.99915 |
KCNK10 | 0.97 | true | true | 0.01 | KCNK17, 0.99885 | KCNK7, 0.998 |
SCN7A | 0.97 | true | true | 0.01 | SCN4A, 0.9972 | SCN1A, 0.9908 |
SCN3A | 0.97 | true | true | 0.01 | SCN2A, 0.99714 | SCN1A, 0.99295 |
KCND3 | 0.97 | true | true | 0.01 | KCND2, 0.99833 | KCNC2, 0.99802 |
GRIN1 | 0.97 | true | true | 0.01 | GRIN2D, 0.99407 | GRIN2B, 0.99311 |
SCNN1A | 0.97 | true | true | 0.01 | SCNN1B, 0.99146 | ASIC3, 0.99117 |
HTR3A | 0.97 | true | true | 0.01 | CHRNG, 0.99783 | CHRNA2, 0.99774 |
KCNH7 | 0.97 | true | true | 0.01 | KCNH3, 0.99447 | KCNH5, 0.99446 |
HCN2 | 0.97 | true | true | 0.01 | HCN1, 0.98887 | HCN3, 0.98726 |
KCNN3 | 0.97 | true | true | 0.01 | KCNK3, 0.99658 | KCNN1, 0.99557 |
KCNK4 | 0.97 | true | true | 0.01 | KCNK9, 0.99776 | KCNK10, 0.99722 |
KCND1 | 0.97 | true | true | 0.01 | KCNA7, 0.99796 | KCND2, 0.99739 |
CLCNKB | 0.97 | true | true | 0.01 | CLCNKA, 0.99971 | CLCN1, 0.99925 |
GRIN2C | 0.97 | true | true | 0.01 | GRIN2B, 0.99769 | GRIA4, 0.99763 |
CLCN7 | 0.97 | true | true | 0.01 | CLCN6, 0.99926 | CLCN5, 0.99868 |
P2RX6 | 0.96 | true | true | 0.01 | P2RX5, 0.99756 | P2RX2, 0.99731 |
GRIN2A | 0.96 | true | true | 0.01 | GRIN2C, 0.99572 | GRIK3, 0.99486 |
KCNC3 | 0.96 | true | true | 0.01 | KCNA4, 0.99749 | KCNA5, 0.99702 |
CACNA1I | 0.96 | true | true | 0.01 | CACNA1G, 0.99156 | CACNA1H, 0.98126 |
CLCN6 | 0.96 | true | true | 0.01 | CLCN7, 0.99926 | CLCN2, 0.99826 |
KCND2 | 0.96 | true | true | 0.01 | KCND3, 0.99833 | KCNC1, 0.99776 |
ASIC2 | 0.96 | true | true | 0.01 | SCNN1B, 0.9968 | SCNN1G, 0.99534 |
CLCN4 | 0.96 | true | true | 0.01 | CLCN5, 0.99887 | CLCN7, 0.99838 |
CNGA3 | 0.96 | true | true | 0.01 | HCN1, 0.97986 | HCN2, 0.97879 |
CHRNA1 | 0.96 | true | true | 0.01 | CHRNB3, 0.99895 | CHRNA10, 0.99769 |
HCN4 | 0.96 | true | true | 0.01 | HCN1, 0.9915 | HCN2, 0.98084 |
TRPV4 | 0.96 | true | true | 0.01 | TRPV6, 0.97208 | TRPV5, 0.97059 |
SCNN1B | 0.96 | true | true | 0.01 | ASIC3, 0.99912 | SCNN1D, 0.99864 |
P2RX4 | 0.96 | true | true | 0.01 | P2RX7, 0.99763 | P2RX1, 0.99584 |
CLCNKA | 0.96 | true | true | 0.01 | CLCNKB, 0.99971 | CLCN1, 0.99952 |
KCNK2 | 0.96 | true | true | 0.01 | KCNK9, 0.99839 | KCNK10, 0.99597 |
CLIC2 | 0.96 | true | true | 0.01 | CLIC3, 0.99674 | CLIC5, 0.99585 |
P2RX1 | 0.96 | true | true | 0.01 | P2RX3, 0.99867 | P2RX7, 0.99701 |
KCNQ4 | 0.96 | true | true | 0.01 | KCNQ2, 0.99014 | KCNQ5, 0.9892 |
CLCA2 | 0.96 | true | true | 0.01 | CLCA1, 0.99908 | CLCA4, 0.99881 |
CACNA1B | 0.96 | true | true | 0.01 | CACNA1E, 0.97774 | CACNA1A, 0.96007 |
KCNQ3 | 0.96 | true | true | 0.01 | KCNQ4, 0.98902 | KCNQ2, 0.98527 |
GABRG3 | 0.96 | true | true | 0.01 | GABRG1, 0.99679 | GABRG2, 0.99382 |
GRID2 | 0.96 | true | true | 0.01 | GRIK1, 0.99893 | GRID1, 0.996 |
P2RX2 | 0.96 | true | true | 0.01 | P2RX6, 0.99731 | P2RX7, 0.99672 |
CLCA4 | 0.96 | true | true | 0.01 | CLCA1, 0.99934 | CLCA2, 0.99881 |
CLCA1 | 0.96 | true | true | 0.01 | CLCA4, 0.99934 | CLCA2, 0.99908 |
CHRND | 0.96 | true | true | 0.01 | CHRNE, 0.99843 | HTR3B, 0.99821 |
CACNA1E | 0.96 | true | true | 0.01 | CACNA1B, 0.97774 | CACNA1A, 0.95304 |
SCN9A | 0.96 | true | true | 0.01 | SCN8A, 0.9955 | SCN5A, 0.99348 |
GRIN2D | 0.95 | true | true | 0.01 | GRIA4, 0.99495 | GRIN1, 0.99407 |
TRPV6 | 0.95 | true | true | 0.01 | TRPV5, 0.99754 | TRPV4, 0.97208 |
GABRA2 | 0.95 | true | true | 0.01 | GABRA4, 0.99926 | GABRB2, 0.99728 |
TRPV5 | 0.95 | true | true | 0.01 | TRPV6, 0.99754 | TRPV4, 0.97059 |
KCNK15 | 0.95 | true | true | 0.01 | KCNK6, 0.99795 | KCNK5, 0.99704 |
TRPC1 | 0.95 | true | true | 0.01 | TRPC6, 0.99116 | TRPC3, 0.99074 |
CLIC5 | 0.95 | true | true | 0.01 | CLIC2, 0.99585 | CLIC3, 0.99524 |
CLIC3 | 0.95 | true | true | 0.01 | CLIC2, 0.99674 | CLIC5, 0.99524 |
P2RX3 | 0.95 | true | true | 0.01 | P2RX1, 0.99867 | P2RX7, 0.99702 |
KCNK9 | 0.95 | true | true | 0.01 | KCNK2, 0.99839 | KCNK4, 0.99776 |
GRIA3 | 0.95 | true | true | 0.01 | GRIN2B, 0.99694 | GRIK2, 0.99624 |
KCNK3 | 0.95 | true | true | 0.01 | KCNK6, 0.99807 | KCNK4, 0.9972 |
P2RX5 | 0.95 | true | true | 0.01 | P2RX6, 0.99756 | P2RX2, 0.9967 |
KCNK6 | 0.95 | true | true | 0.01 | KCNK5, 0.99851 | KCNK3, 0.99807 |
P2RX7 | 0.94 | true | true | 0.01 | P2RX4, 0.99763 | P2RX3, 0.99702 |
SCNN1D | 0.94 | true | true | 0.01 | ASIC3, 0.9996 | SCNN1B, 0.99864 |
TPCN1 | 0.94 | true | true | 0.01 | TPCN2, 0.97525 | HVCN1, 0.93772 |
KCNQ5 | 0.94 | true | true | 0.01 | KCNQ4, 0.9892 | KCNQ3, 0.98396 |
KCNN1 | 0.94 | true | true | 0.01 | KCNN3, 0.99557 | KCNK3, 0.99535 |
ASIC1 | 0.94 | true | true | 0.01 | SCNN1G, 0.99913 | SCNN1B, 0.99727 |
CACNA1H | 0.94 | true | true | 0.01 | CACNA1G, 0.98357 | CACNA1I, 0.98126 |
KCNH2 | 0.94 | true | true | 0.01 | KCNH3, 0.99579 | KCNH6, 0.99318 |
ITPR2 | 0.93 | true | true | 0.01 | ITPR1, 0.98551 | ITPR3, 0.97422 |
CHRNA9 | 0.93 | true | true | 0.01 | CHRNA2, 0.99673 | CHRNG, 0.99587 |
TRPV2 | 0.93 | true | true | 0.01 | TRPV4, 0.96245 | TRPV6, 0.95471 |
KCNJ2 | 0.93 | true | true | 0.01 | KCNJ8, 0.99697 | KCNJ12, 0.99543 |
KCNK1 | 0.92 | true | true | 0.01 | KCNK5, 0.9943 | KCNK3, 0.99358 |
FXYD2 | 0.92 | false | true | 0.01 | FXYD1, 0.98767 | FXYD4, 0.9827 |
CLIC1 | 0.92 | true | true | 0.01 | CLIC5, 0.98702 | CLIC4, 0.98652 |
CACNA1G | 0.92 | true | true | 0.01 | CACNA1I, 0.99156 | CACNA1H, 0.98357 |
GABRP | 0.92 | true | true | 0.01 | CHRNA1, 0.98065 | GABRE, 0.98011 |
GABRE | 0.92 | true | true | 0.01 | CHRNB1, 0.99453 | GLRB, 0.9942 |
GABRB1 | 0.92 | true | true | 0.01 | GABRA5, 0.99602 | GABRA4, 0.99597 |
CHRNB4 | 0.92 | true | true | 0.01 | CHRNA3, 0.99888 | GABRQ, 0.99762 |
CACNA2D1 | 0.92 | true | true | 0.01 | CACNA2D2, 0.99507 | CACNA2D3, 0.9941 |
GABRA5 | 0.91 | true | true | 0.01 | GABRB1, 0.99602 | GABRA2, 0.99549 |
CHRNE | 0.91 | true | true | 0.01 | CHRND, 0.99843 | HTR3B, 0.99689 |
RYR2 | 0.91 | true | true | 0.01 | RYR1, 0.99221 | RYR3, 0.98886 |
CLIC4 | 0.91 | true | true | 0.01 | CLIC1, 0.98652 | CLIC3, 0.9825 |
KCNV2 | 0.91 | true | true | 0.01 | KCNG4, 0.99854 | KCNS1, 0.99781 |
KCNK5 | 0.91 | true | true | 0.01 | KCNK6, 0.99851 | KCNK15, 0.99704 |
KCNK17 | 0.9 | true | true | 0.01 | KCNK7, 0.99917 | KCNK10, 0.99885 |
HVCN1 | 0.9 | true | true | 0.01 | TPCN2, 0.9657 | NALCN, 0.95342 |
ITPR1 | 0.9 | true | true | 0.01 | ITPR2, 0.98551 | ITPR3, 0.9708 |
TRPV3 | 0.9 | true | true | 0.01 | TRPV5, 0.96106 | TRPV6, 0.95678 |
TRPM1 | 0.88 | true | true | 0.01 | TRPM8, 0.92774 | TRPM3, 0.92302 |
ITPR3 | 0.88 | true | true | 0.01 | ITPR2, 0.97422 | ITPR1, 0.9708 |
KCNN4 | 0.88 | true | true | 0.01 | KCNK5, 0.98874 | KCNK1, 0.98852 |
RYR3 | 0.88 | true | true | 0.01 | RYR2, 0.98886 | RYR1, 0.98193 |
TRPM8 | 0.87 | true | true | 0.01 | TRPM1, 0.92774 | CATSPER1, 0.91886 |
TMC5 | 0.86 | true | true | 0.01 | TMC7, 0.99957 | TMC4, 0.99947 |
CACHD1 | 0.86 | false | false | 0.01 | CACNA2D3, 0.99793 | CACNA2D1, 0.99616 |
GRIN3B | 0.86 | true | true | 0.01 | GRIN2C, 0.99174 | GRIA4, 0.99163 |
TMC4 | 0.86 | true | true | 0.01 | TMC5, 0.99947 | TMC6, 0.99928 |
HCN3 | 0.86 | true | true | 0.01 | HCN2, 0.98726 | HCN1, 0.97784 |
TMC6 | 0.86 | true | true | 0.01 | TMC8, 0.99962 | TMC4, 0.99928 |
RYR1 | 0.86 | true | true | 0.01 | RYR2, 0.99221 | RYR3, 0.98193 |
KCNK7 | 0.86 | true | true | 0.01 | KCNK17, 0.99917 | KCNK10, 0.998 |
GRIN3A | 0.86 | true | true | 0.01 | GRIN2B, 0.99141 | GRIN1, 0.9911 |
TRPM3 | 0.85 | true | true | 0.01 | TRPM1, 0.92302 | |
KCNAB3 | 0.84 | true | true | 0.01 | KCNAB2, 0.99744 | KCNAB1, 0.99694 |
TMC7 | 0.84 | true | true | 0.01 | TMC5, 0.99957 | TMC4, 0.99885 |
KCNB2 | 0.83 | true | true | 0.01 | KCNS1, 0.99636 | KCNF1, 0.99582 |
KCNAB1 | 0.83 | true | true | 0.01 | KCNAB3, 0.99694 | KCNAB2, 0.99431 |
TMC8 | 0.83 | true | true | 0.01 | TMC6, 0.99962 | TMC4, 0.99926 |
CHRNA5 | 0.82 | true | true | 0.01 | CHRNB1, 0.99587 | CHRNB4, 0.99477 |
FXYD7 | 0.82 | true | true | 0.01 | FXYD1, 0.96614 | FXYD4, 0.95554 |
CHRNA4 | 0.82 | true | true | 0.01 | CHRNA2, 0.99733 | HTR3A, 0.99718 |
C15ORF27 | 0.81 | false | false | 0.01 | NALCN, 0.90158 | |
CHRNB1 | 0.81 | true | true | 0.01 | CHRNB4, 0.99718 | CHRNA3, 0.99593 |
HTR3B | 0.8 | true | true | 0.01 | CHRND, 0.99821 | CHRNE, 0.99689 |
KCNIP1 | 0.8 | true | true | 0.01 | KCNIP3, 0.9788 | KCNIP2, 0.97872 |
TMC1 | 0.8 | true | true | 0.01 | TMC4, 0.99905 | TMC6, 0.99895 |
KCNAB2 | 0.79 | true | true | 0.01 | KCNAB3, 0.99744 | KCNAB1, 0.99431 |
FXYD6 | 0.78 | true | true | 0.01 | FXYD1, 0.9753 | FXYD5, 0.96285 |
CACNB2 | 0.77 | true | true | 0.01 | CACNB4, 0.98634 | CACNB3, 0.95779 |
KCNIP3 | 0.76 | true | true | 0.01 | KCNIP2, 0.98347 | KCNIP1, 0.9788 |
NOX3 | 0.75 | false | true | 0.01 | NOX1, 0.99721 | CYBB, 0.97673 |
CACNA2D3 | 0.75 | true | true | 0.01 | CACNA2D1, 0.9941 | CACNA2D2, 0.9931 |
CACNB1 | 0.75 | true | true | 0.01 | CACNB3, 0.94551 | CACNB4, 0.92622 |
KCNIP4 | 0.74 | true | true | 0.01 | KCNIP1, 0.97752 | KCNIP2, 0.97354 |
FXYD1 | 0.74 | true | true | 0.01 | FXYD4, 0.9783 | FXYD6, 0.9753 |
KCNIP2 | 0.74 | true | true | 0.01 | KCNIP3, 0.98347 | KCNIP1, 0.97872 |
FXYD3 | 0.73 | true | true | 0.01 | FXYD5, 0.92197 | FXYD6, 0.91762 |
CACNA2D4 | 0.73 | true | true | 0.01 | CACNA2D2, 0.99427 | CACNA2D3, 0.98862 |
KCNE1 | 0.73 | true | true | 0.01 | KCNE2, 0.99954 | KCNE3, 0.99836 |
KCTD8 | 0.71 | false | false | 0.01 | KCND2, 0.97515 | KCNG3, 0.97361 |
TTYH3 | 0.71 | true | true | 0.01 | TTYH2, 0.99954 | TTYH1, 0.9991 |
FAM26E | 0.7 | true | true | 0.01 | CALHM2, 0.99884 | FAM26F, 0.99861 |
TTYH1 | 0.7 | true | true | 0.01 | TTYH2, 0.99932 | TTYH3, 0.9991 |
TRPM4 | 0.7 | true | true | 0.01 | ||
KCNE2 | 0.68 | true | true | 0.01 | KCNE1, 0.99954 | KCNE3, 0.9992 |
FXYD5 | 0.68 | true | true | 0.01 | FXYD6, 0.96285 | FXYD1, 0.95294 |
CACNB3 | 0.68 | true | true | 0.01 | CACNB2, 0.95779 | CACNB4, 0.95034 |
KCNE4 | 0.67 | true | true | 0.01 | KCNE3, 0.99925 | KCNE2, 0.99842 |
KCNT2 | 0.66 | true | true | 0.01 | KCNN2, 0.98765 | KCNK4, 0.98652 |
TRPM2 | 0.66 | true | true | 0.01 | CACNA1H, 0.91643 | CACNA1I, 0.90803 |
PKD2 | 0.66 | true | true | 0.01 | PKD2L1, 0.92985 | |
MCOLN2 | 0.66 | true | true | 0.01 | MCOLN3, 0.92849 | |
KCNE3 | 0.65 | true | true | 0.01 | KCNE4, 0.99925 | KCNE2, 0.9992 |
TRPA1 | 0.65 | true | true | 0.01 | TRPV6, 0.90201 | TRPV5, 0.90079 |
KCNT1 | 0.65 | true | true | 0.01 | KCNT2, 0.98182 | KCNK4, 0.98059 |
GLRB | 0.65 | true | true | 0.01 | GABRA4, 0.99581 | GABRB2, 0.99558 |
NOX4 | 0.65 | false | true | 0.01 | NOX1, 0.995 | CYBB, 0.98933 |
BEST1 | 0.64 | true | true | 0.01 | BEST3, 0.91374 | |
PKD2L1 | 0.64 | true | true | 0.01 | PKD2L2, 0.94909 | PKD2, 0.92985 |
FAM26F | 0.63 | true | true | 0.01 | CALHM2, 0.99933 | FAM26E, 0.99861 |
CNGB3 | 0.62 | true | true | 0.01 | CNGB1, 0.99361 | CNGA1, 0.9572 |
FXYD4 | 0.62 | true | true | 0.01 | FXYD1, 0.9783 | FXYD6, 0.95846 |
TRPM7 | 0.62 | true | true | 0.01 | ||
TTYH2 | 0.61 | true | true | 0.01 | TTYH3, 0.99954 | TTYH1, 0.99932 |
KCNMA1 | 0.6 | true | true | 0.01 | ||
KLHL5 | 0.59 | false | true | 0.02 | ||
BEST2 | 0.59 | true | true | 0.02 | ||
MCOLN1 | 0.58 | true | true | 0.02 | ||
CNGB1 | 0.58 | true | true | 0.02 | CNGB3, 0.99361 | CNGA2, 0.96178 |
KCNJ14 | 0.58 | true | true | 0.02 | KCNJ13, 0.99942 | KCNJ1, 0.99873 |
BEST4 | 0.57 | true | true | 0.02 | ||
CASK | 0.57 | false | true | 0.02 | ||
PKDREJ | 0.56 | true | true | 0.02 | PKD1L2, 0.9804 | |
KCTD20 | 0.56 | false | false | 0.02 | KCND1, 0.97024 | KCNB1, 0.96932 |
MCOLN3 | 0.55 | true | true | 0.02 | MCOLN2, 0.92849 | PKD2L2, 0.915 |
PKD2L2 | 0.54 | true | true | 0.02 | PKD2L1, 0.94909 | MCOLN3, 0.915 |
PKD1L2 | 0.53 | true | true | 0.02 | PKDREJ, 0.9804 | |
CALHM2 | 0.52 | true | true | 0.02 | FAM26F, 0.99933 | FAM26E, 0.99884 |
ZBTB11 | 0.52 | false | true | 0.02 |