| Name | Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 |
| Description | Dioxygenase that repairs alkylated DNA containing 1-methyladenine (1meA) and 3-methylcytosine (3meC) by oxidative demethylation. Has a strong preference for single-stranded DNA. Able to process alkylated 3mC within double-stranded regions via its interaction with ASCC3, which promotes DNA unwinding to generate single-stranded substrate needed for ALKHB3. May also act on RNA. Requires molecular oxygen, alpha-ketoglutarate and iron. |
| UniProt ID | Q96Q83 |
| Gene | ALKBH3 |
