Name RNA-binding E3 ubiquitin-protein ligase MEX3C
Description E3 ubiquitin ligase responsible for the post-transcriptional regulation of common HLA-A allotypes. Binds to the 3' UTR of HLA-A2 mRNA, and regulates its levels by promoting mRNA decay. RNA binding is sufficient to prevent translation, but ubiquitin ligase activity is required for mRNA degradation.
UniProt ID Q5U5Q3
Gene MEX3C