NDST4_HUMAN Protein

Name Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 4
Description Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Has low deacetylase activity but high sulfotransferase activity (By similarity).
UniProt ID Q9H3R1
Gene NDST4