| Description |
Sequence-specific RNA-binding protein that negatively regulates translation and mRNA stability by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, called Pumilio Response Element (PRE), 5'-UGUANAUA-3', that is related to the Nanos Response Element (NRE). May regulate DCUN1D3 mRNA levels (PubMed:25349211). Capable of deadenylation-dependent and -independent modes of repression. May support proliferation and self-renewal of stem cells by regulating the translation of key transcripts.
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