Harmonizome 3.0
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SIAH3_HUMAN
Protein
Name
Seven in absentia homolog 3
Description
Negative regulator of PARK2 translocation to damaged mitochondria. Acts probably by destabilizing PINK1 protein, hence inhibiting PARK2 targeting to dysfunctional depolarized mitochondria.
UniProt ID
Q8IW03
Gene
SIAH3