TAB2_HUMAN Protein

Name TGF-beta-activated kinase 1 and MAP3K7-binding protein 2
Description Adapter linking MAP3K7/TAK1 and TRAF6. Promotes MAP3K7 activation in the IL1 signaling pathway. The binding of 'Lys-63'-linked polyubiquitin chains to TAB2 promotes autophosphorylation of MAP3K7 at 'Thr-187'. Involved in heart development.
UniProt ID Q9NYJ8
Gene TAB2