LINCS L1000 Connectivity Map Resource

Description	The L1000 Connectivity Map is a Library of Integrated Network-based Cellular Signatures (LINCS) project that is profiling gene expression changes following pharmacologic or genetic (knockdown or over-expression) perturbation of cell lines in high-throughput (approximately 20000 compounds, 4500 knockdowns, and 3000 over-expressions). The majority of the knockdown perturbations were applied to a core set of 8 cell lines, A375, A549, HA1E, HCC515, HEPG2, HT29, MCF7, and PC3, and most gene expression profiles were measured 96 hours after knockdown.
Citation(s)	Duan, Q et al. (2014) LINCS Canvas Browser: interactive web app to query, browse and interrogate LINCS L1000 gene expression signatures. Nucleic Acids Res. 42:W449-60. Evangelista, JE et al. (2022) SigCom LINCS: data and metadata search engine for a million gene expression signatures. Nucleic Acids Res. 50:W697-709.
Acronym	L1000 CMAP
External Link	https://clue.io/

Datasets

Dataset	Description	Category	Attribute	Views
Signatures of Differentially Expressed Genes for Small Molecules	mRNA expression profiles for cell lines following small molecule perturbation	transcriptomics	small molecule perturbation	17793
CRISPR Knockout Consensus Signatures	Gene association consensus signatures following CRISPR gene knockout	transcriptomics	gene perturbation	33301
Chemical Perturbations Consensus Signatures	Gene association consensus signatures following small molecule perturbation	transcriptomics	small molecule perturbation	7874