LINCS L1000 Connectivity Map Resource

Description The L1000 Connectivity Map is a Library of Integrated Network-based Cellular Signatures (LINCS) project that is profiling gene expression changes following pharmacologic or genetic (knockdown or over-expression) perturbation of cell lines in high-throughput (approximately 20000 compounds, 4500 knockdowns, and 3000 over-expressions). The majority of the knockdown perturbations were applied to a core set of 8 cell lines, A375, A549, HA1E, HCC515, HEPG2, HT29, MCF7, and PC3, and most gene expression profiles were measured 96 hours after knockdown.
Acronym L1000 CMAP
External Link


Dataset Description Category Attribute Views
Signatures of Differentially Expressed Genes for Small Molecules mRNA expression profiles for cell lines following small molecule perturbation transcriptomics small molecule perturbation 8788