Harmonizome 3.0

signal transducer and activator of transcription 3 (acute-phase response factor)

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

From ChEA Transcription Factor Targets

target genes of the STAT3 transcription factor in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.

From ENCODE Transcription Factor Targets

target genes of the STAT3 transcription factor in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term stat3 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From Hub Proteins Protein-Protein Interactions

interacting proteins for hub protein STAT3 from the curated Hub Proteins Protein-Protein Interactions dataset.

From JASPAR Predicted Transcription Factor Targets

target genes of the STAT3 transcription factor predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.

From MotifMap Predicted Transcription Factor Targets

target genes of the STAT3 transcription factor predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for STAT3 from the Pathway Commons Protein-Protein Interactions dataset.

From Phosphosite Textmining Biological Term Annotations

proteins co-occuring with the biological term stat3 in abstracts of publications describing phosphosites from the Phosphosite Textmining Biological Term Annotations dataset.

From LINCS L1000 CMAP CRISPR Knockout Consensus Signatures

genes differentially expressed following the STAT3 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

From MotifMap Predicted Transcription Factor Targets

target genes of the STAT3:STAT3 transcription factor predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.

From Biocarta Pathways

proteins participating in the stat3 signaling pathway pathway from the Biocarta Pathways dataset.

From ChEA Transcription Factor Binding Site Profiles

genes with transcription factor binding evidence in the STAT3-1855785-MESC-mouse transcription factor binding site profile from the CHEA Transcription Factor Binding Site Profiles dataset.

From ChEA Transcription Factor Binding Site Profiles

genes with transcription factor binding evidence in the STAT3-18555785-MESC-MOUSE transcription factor binding site profile from the CHEA Transcription Factor Binding Site Profiles dataset.

From ChEA Transcription Factor Binding Site Profiles

genes with transcription factor binding evidence in the STAT3-20064451-CD4+T-MOUSE transcription factor binding site profile from the CHEA Transcription Factor Binding Site Profiles dataset.

From ChEA Transcription Factor Binding Site Profiles

genes with transcription factor binding evidence in the STAT3-22323479-MACROPHAGE-MOUSE transcription factor binding site profile from the CHEA Transcription Factor Binding Site Profiles dataset.

From ChEA Transcription Factor Binding Site Profiles

genes with transcription factor binding evidence in the STAT3-19079543-MESC-mouse transcription factor binding site profile from the CHEA Transcription Factor Binding Site Profiles dataset.

From ChEA Transcription Factor Binding Site Profiles

genes with transcription factor binding evidence in the STAT3-23295773-U87-HUMAN transcription factor binding site profile from the CHEA Transcription Factor Binding Site Profiles dataset.

From CORUM Protein Complexes

proteins in the IL6ST-PRKCD-STAT3 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the STAT3 homodimer copmplex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the Stat3-Crebbp complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the Isl1-Jak1-Stat3 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the STAT3-NLK-MAP3K7 complex protein complex from the CORUM Protein Complexes dataset.

From ENCODE Transcription Factor Binding Site Profiles

genes with transcription factor binding evidence in the STAT3_HeLa-S3_hg19_1 transcription factor binding site profile from the ENCODE Transcription Factor Binding Site Profiles dataset.

From ENCODE Transcription Factor Binding Site Profiles

genes with transcription factor binding evidence in the STAT3_GM12878_hg19_1 transcription factor binding site profile from the ENCODE Transcription Factor Binding Site Profiles dataset.

From ENCODE Transcription Factor Binding Site Profiles

genes with transcription factor binding evidence in the STAT3_MCF 10A_hg19_3 transcription factor binding site profile from the ENCODE Transcription Factor Binding Site Profiles dataset.

From ENCODE Transcription Factor Binding Site Profiles

genes with transcription factor binding evidence in the STAT3_MCF 10A_hg19_1 transcription factor binding site profile from the ENCODE Transcription Factor Binding Site Profiles dataset.

From ENCODE Transcription Factor Binding Site Profiles

genes with transcription factor binding evidence in the STAT3_MCF 10A_hg19_2 transcription factor binding site profile from the ENCODE Transcription Factor Binding Site Profiles dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term stat3rantes in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term stat3deficient in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term stat3skp2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term stat3bound in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term stat3interleukin6 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term stat3ape1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term stat3pim1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term stat3re in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term stat3regulated in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term stat3beta in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term stat3microrna in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term stat3prl3 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term stat3usp7p53 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term stat3survivin in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term stat35 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term stat3hsp90 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term stat3depleted in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term stat3sclip in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term stat3lgr4 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term stat3jak2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term stat3activating in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term stat3pim1nfat in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term stat3induced in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term stat3p63jaggednotch in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term stat3mediated in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term stat3signaling in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term stat3alpha in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term stat3gp130 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term stat3dependent in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term stat3nfkappab in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term stat3androgen in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term stat3pias3 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term stat3betacatenin in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term stat3ptpn13 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term stat35dependent in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From GEO Signatures of Differentially Expressed Genes for Gene Perturbations

genes differentially expressed following the STAT3_OE_GDS3444_576_mouse_Cultured embryonic stem (ES) cells gene perturbation from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.

From GEO Signatures of Differentially Expressed Genes for Gene Perturbations

genes differentially expressed following the STAT3_deficiency_GDS3106_58_mouse_type II alveolar cells gene perturbation from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.

From GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations

genes differentially expressed following the stat3_18070348_alveolar_type_2_epithelial_lof_mouse_gpl1261_gds3106 transcription factor perturbation from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset.

From GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations

genes differentially expressed following the stat3_00000000_a549_lof_human_gpl571_gse42979 transcription factor perturbation from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset.

From GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations

genes differentially expressed following the stat3_18500982_mesc_gof_mouse_gpl83_gds3446 transcription factor perturbation from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset.

From GO Biological Process Annotations 2015

genes participating in the positive regulation of tyrosine phosphorylation of stat3 protein biological process from the curated GO Biological Process Annotations 2015 dataset.

From GO Biological Process Annotations 2015

genes participating in the serine phosphorylation of stat3 protein biological process from the curated GO Biological Process Annotations 2015 dataset.

From GO Biological Process Annotations 2015

genes participating in the tyrosine phosphorylation of stat3 protein biological process from the curated GO Biological Process Annotations 2015 dataset.

From GO Biological Process Annotations 2015

genes participating in the negative regulation of tyrosine phosphorylation of stat3 protein biological process from the curated GO Biological Process Annotations 2015 dataset.

From GO Biological Process Annotations 2015

genes participating in the regulation of tyrosine phosphorylation of stat3 protein biological process from the curated GO Biological Process Annotations 2015 dataset.

From Reactome Pathways 2014

proteins participating in the Signalling to STAT3 pathway from the Reactome Pathways dataset.

From WikiPathways Pathways 2014

proteins participating in the Serotonin Receptor 2 and STAT3 Signaling(Homo sapiens) pathway from the WikiPathways Pathways 2014 dataset.

From KnockTF Gene Expression Profiles with Transcription Factor Perturbations

genesdifferentially expressed following the STAT3_01_168 trascription factor perturbation from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset.

From KnockTF Gene Expression Profiles with Transcription Factor Perturbations

genesdifferentially expressed following the STAT3_01_180 trascription factor perturbation from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset.

From KnockTF Gene Expression Profiles with Transcription Factor Perturbations

genesdifferentially expressed following the STAT3_01_181 trascription factor perturbation from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset.

From KnockTF Gene Expression Profiles with Transcription Factor Perturbations

genesdifferentially expressed following the STAT3_01_184 trascription factor perturbation from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset.

From KnockTF Gene Expression Profiles with Transcription Factor Perturbations

genesdifferentially expressed following the STAT3_01_334 trascription factor perturbation from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset.

From KnockTF Gene Expression Profiles with Transcription Factor Perturbations

genesdifferentially expressed following the STAT3_01_49 trascription factor perturbation from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset.

From KnockTF Gene Expression Profiles with Transcription Factor Perturbations

genesdifferentially expressed following the STAT3_01_84 trascription factor perturbation from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset.

From DisGeNET Gene-Phenotype Associations

genes associated with the phenotype Stat3 Gain Of Function in GWAS and other genetic association datasets from the DisGeNET Gene-Phenotype Associations dataset.

From ChEA Transcription Factor Targets 2022

target genes of the STAT3-22323479-MACROPHAGE-MOUSE transcription factor in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.

From ChEA Transcription Factor Targets 2022

target genes of the STAT3-1855785-MESCS-MOUSE transcription factor in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.

From ChEA Transcription Factor Targets 2022

target genes of the STAT3-19079543-MESCS-MOUSE transcription factor in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.

From ChEA Transcription Factor Targets 2022

target genes of the STAT3-24763339-IMN-ESCS-MOUSE transcription factor in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.

From ChEA Transcription Factor Targets 2022

target genes of the STAT3-18555785-MESCS-MOUSE transcription factor in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.

From ChEA Transcription Factor Targets 2022

target genes of the STAT3-18555785-CHIP-SEQ-ESCS-MOUSE transcription factor in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.

From ChEA Transcription Factor Targets 2022

target genes of the STAT3-20064451-CD4+T-MOUSE transcription factor in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.

From ChEA Transcription Factor Targets 2022

target genes of the STAT3-23295773-U87-HUMAN transcription factor in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.

From ChEA Transcription Factor Targets 2022

target genes of the STAT3-29892750-EML-MOUSE-BONEMARROW transcription factor in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.

From WikiPathways Pathways 2024

proteins participating in the ncRNAs involved in STAT3 signaling in hepatocellular carcinoma pathway from the WikiPathways Pathways 2024 dataset.

From WikiPathways Pathways 2024

proteins participating in the Regulatory circuits of STAT3 signaling pathway from the WikiPathways Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the MET activates STAT3 pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the PTK6 Activates STAT3 pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the STAT3 nuclear events downstream of ALK signaling pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Signalling to STAT3 pathway from the Reactome Pathways 2024 dataset.