Name

NAIP Gene

NLR family, apoptosis inhibitory protein

This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. This copy of the gene is full length; additional copies with truncations and internal deletions are also present in this region of chromosome 5q13. It is thought that this gene is a modifier of spinal muscular atrophy caused by mutations in a neighboring gene, SMN1. The protein encoded by this gene contains regions of homology to two baculovirus inhibitor of apoptosis proteins, and it is able to suppress apoptosis induced by various signals. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

naip Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term naip in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

NAIP Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for NAIP from the Pathway Commons Protein-Protein Interactions dataset.

naip5nlrc4 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term naip5nlrc4 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.