Name

NFATC1 Gene

nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1

The product of this gene is a component of the nuclear factor of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins belonging to this family of transcription factors play a central role in inducible gene transcription during immune response. The product of this gene is an inducible nuclear component. It functions as a major molecular target for the immunosuppressive drugs such as cyclosporin A. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Different isoforms of this protein may regulate inducible expression of different cytokine genes. [provided by RefSeq, Jul 2013]

NFATC2 Gene

nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2

This gene is a member of the nuclear factor of activated T cells (NFAT) family. The product of this gene is a DNA-binding protein with a REL-homology region (RHR) and an NFAT-homology region (NHR). This protein is present in the cytosol and only translocates to the nucleus upon T cell receptor (TCR) stimulation, where it becomes a member of the nuclear factors of activated T cells transcription complex. This complex plays a central role in inducing gene transcription during the immune response. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Apr 2012]

NFATC4 Gene

nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4

This gene encodes a member of the nuclear factor of activated T cells (NFAT) protein family. The encoded protein is part of a DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor stimulation and an inducible nuclear component. NFAT proteins are activated by the calmodulin-dependent phosphatase, calcineurin. The encoded protein plays a role in the inducible expression of cytokine genes in T cells, especially in the induction of interleukin-2 and interleukin-4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

NFATC2IP Gene

nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein

NFAT5 Gene

nuclear factor of activated T-cells 5, tonicity-responsive

The product of this gene is a member of the nuclear factors of activated T cells family of transcription factors. Proteins belonging to this family play a central role in inducible gene transcription during the immune response. This protein regulates gene expression induced by osmotic stress in mammalian cells. Unlike monomeric members of this protein family, this protein exists as a homodimer and forms stable dimers with DNA elements. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

NFAM1 Gene

NFAT activating protein with ITAM motif 1

The protein encoded by this gene is a type I membrane receptor that activates cytokine gene promoters such as the IL-13 and TNF-alpha promoters. The encoded protein contains an immunoreceptor tyrosine-based activation motif (ITAM) and is thought to regulate the signaling and development of B-cells. [provided by RefSeq, Jul 2008]

NFATC3 Gene

nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3

The product of this gene is a member of the nuclear factors of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation and an inducible nuclear component. Other members of this family participate to form this complex also. The product of this gene plays a role in the regulation of gene expression in T cells and immature thymocytes. Several transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Nov 2010]

NFASC Gene

neurofascin

This gene encodes an L1 family immunoglobulin cell adhesion molecule with multiple IGcam and fibronectin domains. The protein functions in neurite outgrowth, neurite fasciculation, and organization of the axon initial segment (AIS) and nodes of Ranvier on axons during early development. Both the AIS and nodes of Ranvier contain high densities of voltage-gated Na+ (Nav) channels which are clustered by interactions with cytoskeletal and scaffolding proteins including this protein, gliomedin, ankyrin 3 (ankyrin-G), and betaIV spectrin. This protein links the AIS extracellular matrix to the intracellular cytoskeleton. This gene undergoes extensive alternative splicing, and the full-length nature of some variants has not been determined.[provided by RefSeq, May 2009]

nfa Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term nfa in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

nfat and hypertrophy of the heart Gene Set

From Biocarta Pathways

proteins participating in the nfat and hypertrophy of the heart pathway from the Biocarta Pathways dataset.

NFAT-JUN-FOS DNA-protein complex Gene Set

From CORUM Protein Complexes

proteins in the NFAT-JUN-FOS DNA-protein complex protein complex from the CORUM Protein Complexes dataset.

Nfatc2ip-Prmt1 Gene Set

From CORUM Protein Complexes

proteins in the Nfatc2ip-Prmt1 protein complex from the CORUM Protein Complexes dataset.

NFATC1_GM12878_hg19_2 Gene Set

From ENCODE Transcription Factor Binding Site Profiles

genes with transcription factor binding evidence in the NFATC1_GM12878_hg19_2 transcription factor binding site profile from the ENCODE Transcription Factor Binding Site Profiles dataset.

NFATC1_GM12878_hg19_1 Gene Set

From ENCODE Transcription Factor Binding Site Profiles

genes with transcription factor binding evidence in the NFATC1_GM12878_hg19_1 transcription factor binding site profile from the ENCODE Transcription Factor Binding Site Profiles dataset.

NFATC1 Gene Set

From ENCODE Transcription Factor Targets

target genes of the NFATC1 transcription factor in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.

nfat4 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term nfat4 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

nfat5 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term nfat5 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

nfat1 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term nfat1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

nfat2 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term nfat2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

nfat3 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term nfat3 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

nfatc Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term nfatc in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

nfatc2nuclear Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term nfatc2nuclear in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

nfatgfp Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term nfatgfp in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

nfat3lcn2 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term nfat3lcn2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

nfatp Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term nfatp in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

nfatc2egr1 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term nfatc2egr1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

nfatcmyc Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term nfatcmyc in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

nfatmediated Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term nfatmediated in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

nfatc1mediated Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term nfatc1mediated in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

nfat Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term nfat in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

nfar2 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term nfar2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

nfatc1 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term nfatc1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

nfatc2 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term nfatc2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

nfatc3 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term nfatc3 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

nfatc4 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term nfatc4 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

nfatc1mir125a Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term nfatc1mir125a in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

nfatbinding Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term nfatbinding in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

nfatdependent Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term nfatdependent in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

nfats Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term nfats in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

nfatc1induced Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term nfatc1induced in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

nfat2dependent Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term nfat2dependent in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

calcineurin-nfat signaling cascade Gene Set

From GO Biological Process Annotations

genes participating in the calcineurin-nfat signaling cascade biological process from the curated GO Biological Process Annotations dataset.

positive regulation of nfat protein import into nucleus Gene Set

From GO Biological Process Annotations

genes participating in the positive regulation of nfat protein import into nucleus biological process from the curated GO Biological Process Annotations dataset.

nfat protein import into nucleus Gene Set

From GO Biological Process Annotations

genes participating in the nfat protein import into nucleus biological process from the curated GO Biological Process Annotations dataset.

negative regulation of calcineurin-nfat signaling cascade Gene Set

From GO Biological Process Annotations

genes participating in the negative regulation of calcineurin-nfat signaling cascade biological process from the curated GO Biological Process Annotations dataset.

negative regulation of nfat protein import into nucleus Gene Set

From GO Biological Process Annotations

genes participating in the negative regulation of nfat protein import into nucleus biological process from the curated GO Biological Process Annotations dataset.

regulation of nfat protein import into nucleus Gene Set

From GO Biological Process Annotations

genes participating in the regulation of nfat protein import into nucleus biological process from the curated GO Biological Process Annotations dataset.

regulation of calcineurin-nfat signaling cascade Gene Set

From GO Biological Process Annotations

genes participating in the regulation of calcineurin-nfat signaling cascade biological process from the curated GO Biological Process Annotations dataset.

positive regulation of calcineurin-nfat signaling cascade Gene Set

From GO Biological Process Annotations

genes participating in the positive regulation of calcineurin-nfat signaling cascade biological process from the curated GO Biological Process Annotations dataset.

nfat protein binding Gene Set

From GO Molecular Function Annotations

genes performing the nfat protein binding molecular function from the curated GO Molecular Function Annotations dataset.

Nuclear factor of activated T cells (NFAT) Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Nuclear factor of activated T cells (NFAT) protein domain from the InterPro Predicted Protein Domain Annotations dataset.

NFATC2 Gene Set

From JASPAR Predicted Transcription Factor Targets

target genes of the NFATC2 transcription factor predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.

NFAT2 Gene Set

From MotifMap Predicted Transcription Factor Targets

target genes of the NFAT2 transcription factor predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.

SC-8405 (NFATC3) Gene Set

From NURSA Protein Complexes

proteins in the SC-8405 (NFATC3) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

NFATC2IP Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for NFATC2IP from the Pathway Commons Protein-Protein Interactions dataset.

NFAT5 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for NFAT5 from the Pathway Commons Protein-Protein Interactions dataset.

NFATC1 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for NFATC1 from the Pathway Commons Protein-Protein Interactions dataset.

NFATC3 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for NFATC3 from the Pathway Commons Protein-Protein Interactions dataset.

NFAM1 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for NFAM1 from the Pathway Commons Protein-Protein Interactions dataset.

NFATC2 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for NFATC2 from the Pathway Commons Protein-Protein Interactions dataset.

NFATC4 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for NFATC4 from the Pathway Commons Protein-Protein Interactions dataset.

NFASC Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for NFASC from the Pathway Commons Protein-Protein Interactions dataset.

Calcineurin-regulated NFAT-dependent transcription in lymphocytes Gene Set

From PID Pathways

proteins participating in the Calcineurin-regulated NFAT-dependent transcription in lymphocytes pathway from the PID Pathways dataset.

Role of Calcineurin-dependent NFAT signaling in lymphocytes Gene Set

From PID Pathways

proteins participating in the Role of Calcineurin-dependent NFAT signaling in lymphocytes pathway from the PID Pathways dataset.

NFATC1 Gene Set

From TRANSFAC Predicted Transcription Factor Targets

target genes of the NFATC1 transcription factor predicted using known transcription factor binding site motifs from the TRANSFAC Predicted Transcription Factor Targets dataset.

NFATC3 Gene Set

From TRANSFAC Predicted Transcription Factor Targets

target genes of the NFATC3 transcription factor predicted using known transcription factor binding site motifs from the TRANSFAC Predicted Transcription Factor Targets dataset.