NPHP3 Gene

nephronophthisis 3 (adolescent)

This gene encodes a protein containing a coiled-coil (CC) domain, a tubulin-tyrosine ligase (TTL) domain, and a tetratrico peptide repeat (TPR) domain. The encoded protein interacts with nephrocystin, it is required for normal ciliary development, and it functions in renal tubular development. Mutations in this gene are associated with nephronophthisis type 3, and also with renal-hepatic-pancreatic dysplasia, and Meckel syndrome type 7. Naturally occurring read-through transcripts exist between this gene and the downstream ACAD11 (acyl-CoA dehydrogenase family, member 11) gene. [provided by RefSeq, Feb 2011]


NPHP3-ACAD11 readthrough (NMD candidate)

This locus represents naturally occurring read-through transcription between the neighboring NPHP3 (nephronophthisis 3, adolescent) and ACAD11 (acyl-CoA dehydrogenase family, member 11) genes on chromosome 3. The read-through transcript is a candidate for nonsense-mediated mRNA decay (NMD), and is thus unlikely to produce a protein product. [provided by RefSeq, Feb 2011]

NPHP3-AS1 Gene

NPHP3 antisense RNA 1

nphp3 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term nphp3 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

NPHP3 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for NPHP3 from the Pathway Commons Protein-Protein Interactions dataset.