Harmonizome

From Gene Ontology

curated annotations of genes with biological processes

From Nuclear Receptor Signaling Atlas

proteins identified in complexes isolated from cultured cells

From Nuclear Receptor Signaling Atlas

protein-protein interactions inferred from membership in complexes

mitochondrial fission process 1

MTP18 is a mitochondrial protein and downstream target of the phosphatidylinositol 3-kinase (see PIK3CA, MIM 171834) signaling pathway that plays a role in cell viability and mitochondrial dynamics (Tondera et al., 2004 [PubMed 15155745]).[supplied by OMIM, Mar 2008]

UPF1 regulator of nonsense transcripts homolog (yeast)

This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located only in the cytoplasm. When translation ends, it interacts with the protein that is a functional homolog of yeast Upf2p to trigger mRNA decapping. Use of multiple polyadenylation sites has been noted for this gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

UPF2 regulator of nonsense transcripts homolog (yeast)

This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located in the perinuclear area. It interacts with translation release factors and the proteins that are functional homologs of yeast Upf1p and Upf3p. Two splice variants have been found for this gene; both variants encode the same protein. [provided by RefSeq, Jul 2008]

UPF3 regulator of nonsense transcripts homolog A (yeast)

This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The encoded protein is one of two functional homologs to yeast Upf3p. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions. This gene is located on the long arm of chromosome 13. Two splice variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

UPF3 regulator of nonsense transcripts homolog B (yeast)

This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The encoded protein is one of two functional homologs to yeast Upf3p. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions. This gene is located on the long arm of chromosome X. Two splice variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

UPF3 regulator of nonsense transcripts homolog B (yeast) pseudogene

regulation of nuclear pre-mRNA domain containing 1A

This gene encodes a cell-cycle and transcription regulatory protein. The encoded protein interacts with the cell cycle inhibitor cyclin-dependent kinase 4 inhibitor B and may function as a negative regulator of G(1)/S phase progression. This protein also forms homo- and hetrodimers with the protein, regulation of nuclear pre-mRNA domain-containing protein 1B, to form a scaffold that interacts with the C-terminal domain of RNA polymerase II subunit B1 and regulates several aspects of transcription. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 16. [provided by RefSeq, Dec 2014]

regulation of nuclear pre-mRNA domain containing 1B

regulation of nuclear pre-mRNA domain containing 2

regulation of nuclear pre-mRNA domain containing 1A pseudogene

SERPINE1 mRNA binding protein 1 pseudogene

enhancer of mRNA decapping 3

EDC3 is associated with an mRNA-decapping complex required for removal of the 5-prime cap from mRNA prior to its degradation from the 5-prime end (Fenger-Gron et al., 2005 [PubMed 16364915]).[supplied by OMIM, Mar 2008]

enhancer of mRNA decapping 4

crooked neck pre-mRNA splicing factor 1

The crooked neck (crn) gene of Drosophila is essential for embryogenesis and is thought to be involved in cell cycle progression and pre-mRNA splicing. A protein encoded by this human locus has been found to localize to pre-mRNA splicing complexes in the nucleus and is necessary for pre-mRNA splicing. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2013]

SYF2 pre-mRNA-splicing factor pseudogene 2

SYF2 pre-mRNA-splicing factor pseudogene 1

decapping mRNA 2

The protein encoded by this gene is a key component of an mRNA-decapping complex required for degradation of mRNAs, both in normal mRNA turnover, and in nonsense-mediated mRNA decay (NMD). It removes the 7-methyl guanine cap structure from mRNA, prior to its degradation from the 5' end. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jun 2011]

apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2

SYF2 pre-mRNA-splicing factor

This gene encodes a nuclear protein that interacts with cyclin D-type binding-protein 1, which is thought to be a cell cycle regulator at the G1/S transition. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

SERPINE1 mRNA binding protein 1 pseudogene 1

SERPINE1 mRNA binding protein 1 pseudogene 3

SERPINE1 mRNA binding protein 1 pseudogene 2

SERPINE1 mRNA binding protein 1 pseudogene 5

SERPINE1 mRNA binding protein 1 pseudogene 4

SERPINE1 mRNA binding protein 1 pseudogene 6

pre-mRNA processing factor 3 pseudogene

NAG18 mRNA

pre-mRNA processing factor 4B

Pre-mRNA splicing occurs in two sequential transesterification steps, and the protein encoded by this gene is thought to be involved in pre-mRNA splicing and in signal transduction. This protein belongs to a kinase family that includes serine/arginine-rich protein-specific kinases and cyclin-dependent kinases (CDKs). This protein is regarded as a CDK-like kinase (Clk) with homology to mitogen-activated protein kinases (MAPKs). [provided by RefSeq, Jul 2008]

pre-mRNA processing factor 8

Pre-mRNA splicing occurs in 2 sequential transesterification steps. The protein encoded by this gene is a component of both U2- and U12-dependent spliceosomes, and found to be essential for the catalytic step II in pre-mRNA splicing process. It contains several WD repeats, which function in protein-protein interactions. This protein has a sequence similarity to yeast Prp8 protein. This gene is a candidate gene for autosomal dominant retinitis pigmentosa. [provided by RefSeq, Jul 2008]

pre-mRNA processing factor 3

The removal of introns from nuclear pre-mRNAs occurs on complexes called spliceosomes, which are made up of 4 small nuclear ribonucleoprotein (snRNP) particles and an undefined number of transiently associated splicing factors. This gene product is one of several proteins that associate with U4 and U6 snRNPs. Mutations in this gene are associated with retinitis pigmentosa-18. [provided by RefSeq, Jul 2008]

pre-mRNA processing factor 4

The protein encoded by this gene is part of a heteromeric complex that binds U4, U5, and U6 small nuclear RNAs and is involved in pre-mRNA splicing. The encoded protein also is a mitotic checkpoint protein and a regulator of chemoresistance in human ovarian cancer. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

pre-mRNA processing factor 6

The protein encoded by this gene appears to be involved in pre-mRNA splicing, possibly acting as a bridging factor between U5 and U4/U6 snRNPs in formation of the spliceosome. The encoded protein also can bind androgen receptor, providing a link between transcriptional activation and splicing. [provided by RefSeq, Jul 2008]

mRNA turnover 4 homolog (S. cerevisiae)

This gene encodes a protein sharing a low level of sequence similarity with ribosomal protein P0. While the precise function of the encoded protein is currently unknown, it appears to be involved in mRNA turnover and ribosome assembly. [provided by RefSeq, Jul 2008]

insulin-like growth factor 2 mRNA binding protein 1

This gene encodes a member of the insulin-like growth factor 2 mRNA-binding protein family. The protein encoded by this gene contains four K homology domains and two RNA recognition motifs. It functions by binding to the mRNAs of certain genes, including insulin-like growth factor 2, beta-actin and beta-transducin repeat-containing protein, and regulating their translation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]

insulin-like growth factor 2 mRNA binding protein 2

This gene encodes a member of the IGF-II mRNA-binding protein (IMP) family. The protein encoded by this gene contains four KH domains and two RRM domains. It functions by binding to the 5' UTR of the insulin-like growth factor 2 (IGF2) mRNA and regulating IGF2 translation. Alternative promoter usage and alternate splicing result in multiple variants encoding different isoforms. [provided by RefSeq, May 2014]

pre-mRNA processing factor 19

PSO4 is the human homolog of yeast Pso4, a gene essential for cell survival and DNA repair (Beck et al., 2008 [PubMed 18263876]).[supplied by OMIM, Sep 2008]

pre-mRNA processing factor 18

Pre-mRNA splicing occurs in 2 sequential transesterification steps. The protein encoded by this gene is found to be essential for the catalytic step II in pre-mRNA splicing process. It is found in the spliceosome, and contains seven WD repeats, which function in protein-protein interactions. This protein has a sequence similarity to the yeast splicing factor Prp18. [provided by RefSeq, Jul 2008]

insulin-like growth factor 2 mRNA binding protein 3 pseudogene

PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae)

pre-mRNA processing factor 4B pseudogene

decapping mRNA 1B

DCP1B is a core component of the mRNA decapping complex, a key factor in the regulation of mRNA decay (Lykke-Andersen, 2002 [PubMed 12417715]).[supplied by OMIM, Mar 2008]

decapping mRNA 1A

Decapping is a key step in general and regulated mRNA decay. The protein encoded by this gene is a decapping enzyme. This protein and another decapping enzyme form a decapping complex, which interacts with the nonsense-mediated decay factor hUpf1 and may be recruited to mRNAs containing premature termination codons. This protein also participates in the TGF-beta signaling pathway. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2014]

insulin-like growth factor 2 mRNA binding protein 3

The protein encoded by this gene is primarily found in the nucleolus, where it can bind to the 5' UTR of the insulin-like growth factor II leader 3 mRNA and may repress translation of insulin-like growth factor II during late development. The encoded protein contains several KH domains, which are important in RNA binding and are known to be involved in RNA synthesis and metabolism. A pseudogene exists on chromosome 7, and there are putative pseudogenes on other chromosomes. [provided by RefSeq, Jul 2008]

insulin-like growth factor 2 mRNA binding protein 2 pseudogene

mRNA turnover 4 homolog (S. cerevisiae) pseudogene

PAI-1 mRNA binding protein pseudogene

pre-mRNA processing factor 39

pre-mRNA processing factor 31

This gene encodes a component of the spliceosome complex and is one of several retinitis pigmentosa-causing genes. When the gene product is added to the spliceosome complex, activation occurs.[provided by RefSeq, Jan 2009]

insulin-like growth factor 2 mRNA binding protein 3 pseudogene

apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1

This gene encodes a member of the cytidine deaminase enzyme family. The encoded protein forms a multiple-protein editing holoenzyme with APOBEC1 complementation factor (ACF) and APOBEC1 stimulating protein (ASP). This holoenzyme is involved in the editing of C-to-U nucleotide bases in apolipoprotein B and neurofibromatosis-1 mRNAs. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2015]

apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative)

This gene encodes a member of the AID/APOBEC family of polynucleotide (deoxy)cytidine deaminases, which convert cytidine to uridine. Other AID/APOBEC family members are involved in mRNA editing, somatic hypermutation and recombination of immunoglobulin genes, and innate immunity to retroviral infection. [provided by RefSeq, Jul 2008]

pre-mRNA processing factor 4B pseudogene

SERPINE1 mRNA binding protein 1

insulin-like growth factor 2 mRNA binding protein 2 pseudogene

IGF-II mRNA-binding protein 2-like

mRNA turnover 4 homolog (S. cerevisiae) pseudogene

pre-mRNA processing factor 38A

pre-mRNA processing factor 38B

PRP40 pre-mRNA processing factor 40 homolog B (S. cerevisiae)

This gene encodes a WW-domain containing protein similar to yeast splicing factor PRP40. This protein has been shown to interact with Huntingtin and methyl CpG binding protein 2 (MeCP2). Alternative splicing results in different transcript variants. [provided by RefSeq, Aug 2014]

apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3H

This gene encodes a member of the apolipoprotein B mRNA-editing enzyme catalytic polypeptide 3 family of proteins. The encoded protein is a cytidine deaminase that has antiretroviral activity by generating lethal hypermutations in viral genomes. Polymorphisms and alternative splicing in this gene influence its antiretroviral activity and are associated with increased resistence to human immunodeficiency virus type 1 infection in certain populations. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009]

apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D

This gene is a member of the cytidine deaminase gene family. It is one of a group of related genes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1 and inhibit retroviruses, such as HIV, by deaminating cytosine residues in nascent retroviral cDNA. [provided by RefSeq, Jul 2008]

apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G

This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing enzymes and have roles in growth or cell cycle control. The protein encoded by this gene has been found to be a specific inhibitor of human immunodeficiency virus-1 (HIV-1) infectivity. [provided by RefSeq, Jul 2008]

apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F

This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing enzymes and have roles in growth or cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A

This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. The protein encoded by this gene lacks the zinc binding activity of other family members. The protein plays a role in immunity, by restricting transmission of foreign DNA such as viruses. One mechanism of foreign DNA restriction is deamination of foreign double-stranded DNA cytidines to uridines, which leads to DNA degradation. However, other mechanisms are also thought to be involved, as anti-viral effect is not dependent on deaminase activity. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012]

apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C

This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing enzymes and have roles in growth or cell cycle control. [provided by RefSeq, Jul 2008]

apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B

This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing enzymes and have roles in growth or cell cycle control. A hybrid gene results from the deletion of approximately 29.5 kb of sequence between this gene, APOBEC3B, and the adjacent gene APOBEC3A. The breakpoints of the deletion are within the two genes, so the deletion allele is predicted to have the promoter and coding region of APOBEC3A, but the 3' UTR of APOBEC3B. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012]

nuclear speckle splicing regulatory protein 1

RNA, U5B small nuclear 1

small nuclear ribonucleoprotein polypeptide C pseudogene 6

RNA, U6 small nuclear 67, pseudogene

RNA, U7 small nuclear 36 pseudogene

nuclear receptor subfamily 1, group D, member 1

This gene encodes a transcription factor that is a member of the nuclear receptor subfamily 1. The encoded protein is a ligand-sensitive transcription factor that negatively regulates the expression of core clock proteins. In particular this protein represses the circadian clock transcription factor aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL). This protein may also be involved in regulating genes that function in metabolic, inflammatory and cardiovascular processes. [provided by RefSeq, Jan 2013]

nuclear receptor subfamily 1, group D, member 2

This gene encodes a member of the nuclear hormone receptor family, specifically the NR1 subfamily of receptors. The encoded protein functions as a transcriptional repressor and may play a role in circadian rhythms and carbohydrate and lipid metabolism. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2009]

nuclear pore associated protein 1 pseudogene

heterogeneous nuclear ribonucleoprotein C pseudogene 4

heterogeneous nuclear ribonucleoprotein C pseudogene 2

RNA, U1 small nuclear 16, pseudogene

ligand dependent nuclear receptor interacting factor 1

RNA, U7 small nuclear 53 pseudogene

heterogeneous nuclear ribonucleoprotein F pseudogene 1

RNA, U5A small nuclear 5, pseudogene

nuclear-encoded mitochondrial transfer RNA-Ser (TGA) 3-1

proliferating cell nuclear antigen

The protein encoded by this gene is found in the nucleus and is a cofactor of DNA polymerase delta. The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for this gene. Pseudogenes of this gene have been described on chromosome 4 and on the X chromosome. [provided by RefSeq, Jul 2008]

PEST proteolytic signal containing nuclear protein

TMF1-regulated nuclear protein 1

U2 small nuclear RNA auxiliary factor 1-like 4

RNA, U2 small nuclear 6, pseudogene

SP140 nuclear body protein-like

tandem C2 domains, nuclear

heterogeneous nuclear ribonucleoprotein A1 pseudogene 50

SAM domain, SH3 domain and nuclear localization signals 1

SAMSN1 is a member of a novel gene family of putative adaptors and scaffold proteins containing SH3 and SAM (sterile alpha motif) domains (Claudio et al., 2001 [PubMed 11536050]).[supplied by OMIM, Mar 2008]

heterogeneous nuclear ribonucleoprotein A1 pseudogene 57

heterogeneous nuclear ribonucleoprotein A1 pseudogene 59

small nuclear ribonucleoprotein 27kDa (U4/U6.U5) pseudogene

heterogeneous nuclear ribonucleoprotein A/B pseudogene 1

nuclear casein kinase and cyclin-dependent kinase substrate 1

This gene encodes a nuclear protein that is highly conserved in vertebrates. The conserved regions of the protein contain several consensus phosphorylation sites for casein kinase II and cyclin-dependent kinases, two putative nuclear localization signals, and a basic DNA-binding domain. It is phosphorylated in vivo by Cdk1 during mitosis of the cell cycle. [provided by RefSeq, Aug 2010]

LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) pseudogene

LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae) pseudogene

RNA, U7 small nuclear 1

RNA, U6 small nuclear 46, pseudogene

nuclear-encoded mitochondrial transfer RNA-Leu (TAA) 1-1

nuclear receptor binding factor 2 pseudogene 5

meiotic nuclear divisions 1 homolog (S. cerevisiae) pseudogene

RNA, U5E small nuclear 6, pseudogene

RNA, U7 small nuclear 24 pseudogene

small nuclear ribonucleoprotein D3 polypeptide 18kDa

This gene encodes a core component of the spliceosome, which is a nuclear ribonucleoprotein complex that functions in pre-mRNA splicing. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

small nuclear ribonucleoprotein D2 polypeptide 16.5kDa

The protein encoded by this gene belongs to the small nuclear ribonucleoprotein core protein family. It is required for pre-mRNA splicing and small nuclear ribonucleoprotein biogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]

small nuclear ribonucleoprotein D1 polypeptide 16kDa

This gene encodes a small nuclear ribonucleoprotein that belongs to the SNRNP core protein family. The protein may act as a charged protein scaffold to promote SNRNP assembly or strengthen SNRNP-SNRNP interactions through nonspecific electrostatic contacts with RNA. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]

heterogeneous nuclear ribonucleoprotein A1 pseudogene 63

heterogeneous nuclear ribonucleoprotein A1 pseudogene 68

nuclear protein localization 4 homolog (S. cerevisiae)

nuclear RNA export factor 2B

RNA, U1 small nuclear 28, pseudogene

RNA, U1 small nuclear 13, pseudogene

myeloid cell nuclear differentiation antigen

The myeloid cell nuclear differentiation antigen (MNDA) is detected only in nuclei of cells of the granulocyte-monocyte lineage. A 200-amino acid region of human MNDA is strikingly similar to a region in the proteins encoded by a family of interferon-inducible mouse genes, designated Ifi-201, Ifi-202, and Ifi-203, that are not regulated in a cell- or tissue-specific fashion. The 1.8-kb MNDA mRNA, which contains an interferon-stimulated response element in the 5-prime untranslated region, was significantly upregulated in human monocytes exposed to interferon alpha. MNDA is located within 2,200 kb of FCER1A, APCS, CRP, and SPTA1. In its pattern of expression and/or regulation, MNDA resembles IFI16, suggesting that these genes participate in blood cell-specific responses to interferons. [provided by RefSeq, Jul 2008]

meiotic nuclear divisions 1 homolog (S. cerevisiae)

The product of the MND1 gene associates with HOP2 (MIM 608665) to form a stable heterodimeric complex that binds DNA and stimulates the recombinase activity of RAD51 (MIM 179617) and DMC1 (MIM 602721) (Chi et al., 2007 [PubMed 17639080]). Both the MND1 and HOP2 genes are indispensable for meiotic recombination.[supplied by OMIM, Mar 2008]

RNA, U7 small nuclear 5 pseudogene

nuclear transport factor 2 pseudogene 8

nuclear transport factor 2 pseudogene 2

nuclear transport factor 2 pseudogene 6

nuclear transport factor 2 pseudogene 7

nuclear transport factor 2 pseudogene 4

RNA, U6atac small nuclear 5, pseudogene

heterogeneous nuclear ribonucleoprotein A1 pseudogene 6

required for meiotic nuclear division 1 homolog (S. cerevisiae)

The protein encoded by this gene belongs to the evolutionary conserved sif2 family of proteins that share the DUF155 domain in common. This protein is thought to be localized in the mitochondria and involved in mitochondrial translation. Mutations in this gene are associated with combined oxidative phosphorylation deficiency-11. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2012]

nuclear transcription factor Y, gamma

This gene encodes one subunit of a trimeric complex forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoters of a variety of genes. The encoded protein, subunit C, forms a tight dimer with the B subunit, a prerequisite for subunit A association. The resulting trimer binds to DNA with high specificity and affinity. Subunits B and C each contain a histone-like motif. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]

nuclear transcription factor Y, beta

The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoter regions in a variety of genes. This gene product, subunit B, forms a tight dimer with the C subunit, a prerequisite for subunit A association. The resulting trimer binds to DNA with high specificity and affinity. Subunits B and C each contain a histone-like motif. Observation of the histone nature of these subunits is supported by two types of evidence; protein sequence alignments and experiments with mutants. [provided by RefSeq, Jul 2008]

nuclear transcription factor Y, alpha

The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds to CCAAT motifs in the promoter regions in a variety of genes. Subunit A associates with a tight dimer composed of the B and C subunits, resulting in a trimer that binds to DNA with high specificity and affinity. The sequence specific interactions of the complex are made by the A subunit, suggesting a role as the regulatory subunit. In addition, there is evidence of post-transcriptional regulation in this gene product, either by protein degradation or control of translation. Further regulation is represented by alternative splicing in the glutamine-rich activation domain, with clear tissue-specific preferences for the two isoforms. [provided by RefSeq, Jul 2008]

proliferating cell nuclear antigen pseudogene 1

proliferating cell nuclear antigen pseudogene 4

LSM8 homolog, U6 small nuclear RNA associated (S. cerevisiae)

This gene encodes a member of the like-Sm family of proteins. The encoded protein consists of a closed barrel shape, made up of five anti-parallel beta strands and an alpha helix. This protein partners with six paralogs to form a heteroheptameric ring which transiently binds U6 small nuclear RNAs and is involved in the general maturation of RNA in the nucleus. [provided by RefSeq, Jan 2010]

LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)

This gene encodes a member of the LSm family of RNA-binding proteins. LSm proteins form stable heteromers that bind specifically to the 3'-terminal oligo(U) tract of U6 snRNA and may play a role in pre-mRNA splicing by mediating U4/U6 snRNP formation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)

Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM, Apr 2004]

nuclear RNA export factor 5 pseudogene

LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)

Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM, Apr 2004]

small nuclear ribonucleoprotein polypeptide G pseudogene 9

small nuclear ribonucleoprotein polypeptide G pseudogene 7

small nuclear ribonucleoprotein polypeptide G pseudogene 6

small nuclear ribonucleoprotein polypeptide G pseudogene 5

small nuclear ribonucleoprotein polypeptide G pseudogene 4

small nuclear ribonucleoprotein polypeptide G pseudogene 1

small nuclear ribonucleoprotein polypeptide N pseudogene

nuclear receptor coactivator 2

The NCOA2 gene encodes nuclear receptor coactivator 2, which aids in the function of nuclear hormone receptors. Nuclear hormone receptors are conditional transcription factors that play important roles in various aspects of cell growth, development, and homeostasis by controlling expression of specific genes. Members of the nuclear hormone receptor superfamily, which includes the 5 steroid receptors and class II nuclear receptors (see below), are structurally characterized by 3 distinct domains: an N-terminal transcriptional activation domain, a central DNA-binding domain, and a C-terminal hormone-binding domain. Before the binding of hormone, steroid receptors, which are sometimes called class I of the nuclear hormone receptor family, remain inactive in a complex with heat-shock protein-90 (MIM 140571) and other stress family proteins. Binding of hormone induces critical conformational changes in steroid receptors that cause them to dissociate from the inhibitory complex, bind as homodimers to specific DNA enhancer elements associated with target genes, and modulate that gene's transcription. After binding to enhancer elements, transcription factors require transcriptional coactivator proteins to mediate their stimulation of transcription initiation (Hong et al., 1997 [PubMed 9111344]).[supplied by OMIM, Nov 2010]

nuclear receptor coactivator 3

The protein encoded by this gene is a nuclear receptor coactivator that interacts with nuclear hormone receptors to enhance their transcriptional activator functions. The encoded protein has histone acetyltransferase activity and recruits p300/CBP-associated factor and CREB binding protein as part of a multisubunit coactivation complex. This protein is initially found in the cytoplasm but is translocated into the nucleus upon phosphorylation. Several transcript variants encoding different isoforms have been found for this gene. In addition, a polymorphic repeat region is found in the C-terminus of the encoded protein. [provided by RefSeq, Mar 2010]

nuclear receptor coactivator 1

The protein encoded by this gene acts as a transcriptional coactivator for steroid and nuclear hormone receptors. It is a member of the p160/steroid receptor coactivator (SRC) family and like other family members has histone acetyltransferase activity and contains a nuclear localization signal, as well as bHLH and PAS domains. The product of this gene binds nuclear receptors directly and stimulates the transcriptional activities in a hormone-dependent fashion. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

nuclear receptor coactivator 6

The protein encoded by this gene is a transcriptional coactivator that can interact with nuclear hormone receptors to enhance their transcriptional activator functions. This protein has been shown to be involved in the hormone-dependent coactivation of several receptors, including prostanoid, retinoid, vitamin D3, thyroid hormone, and steroid receptors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jun 2011]

nuclear receptor coactivator 7

nuclear receptor coactivator 4

This gene encodes an androgen receptor coactivator. The encoded protein interacts with the androgen receptor in a ligand-dependent manner to enhance its transcriptional activity. Chromosomal translocations between this gene and the ret tyrosine kinase gene, also located on chromosome 10, have been associated with papillary thyroid carcinoma. Alternatively spliced transcript variants have been described. Pseudogenes are present on chromosomes 4, 5, 10, and 14. [provided by RefSeq, Feb 2009]

nuclear receptor coactivator 5

This gene encodes a coregulator for the alpha and beta estrogen receptors and the orphan nuclear receptor NR1D2. The protein localizes to the nucleus, and is thought to have both coactivator and corepressor functions. Its interaction with nuclear receptors is independent of the AF2 domain on the receptors, which is known to regulate interaction with other coreceptors. Two alternatively spliced transcript variants for this gene have been described. However, the full length nature of one of the variants has not been determined. [provided by RefSeq, Jul 2008]

RNA, U7 small nuclear 62 pseudogene

heterogeneous nuclear ribonucleoprotein A/B

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are produced by RNA polymerase II and are components of the heterogeneous nuclear RNA (hnRNA) complexes. They are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene, which binds to one of the components of the multiprotein editosome complex, has two repeats of quasi-RRM (RNA recognition motif) domains that bind to RNAs. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

heterogeneous nuclear ribonucleoprotein A1 pseudogene 42

heterogeneous nuclear ribonucleoprotein A1 pseudogene 41

heterogeneous nuclear ribonucleoprotein A1 pseudogene 46

heterogeneous nuclear ribonucleoprotein A1 pseudogene 47

heterogeneous nuclear ribonucleoprotein A1 pseudogene 44

heterogeneous nuclear ribonucleoprotein A1 pseudogene 45

heterogeneous nuclear ribonucleoprotein A3

heterogeneous nuclear ribonucleoprotein A0

This gene belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind RNAs, followed by a glycine-rich C-terminus. [provided by RefSeq, Jul 2008]

heterogeneous nuclear ribonucleoprotein A1

This gene belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. It is one of the most abundant core proteins of hnRNP complexes and it is localized to the nucleoplasm. This protein, along with other hnRNP proteins, is exported from the nucleus, probably bound to mRNA, and is immediately re-imported. Its M9 domain acts as both a nuclear localization and nuclear export signal. The encoded protein is involved in the packaging of pre-mRNA into hnRNP particles, transport of poly A+ mRNA from the nucleus to the cytoplasm, and may modulate splice site selection. It is also thought have a primary role in the formation of specific myometrial protein species in parturition. Multiple alternatively spliced transcript variants have been found for this gene but only two transcripts are fully described. These variants have multiple alternative transcription initiation sites and multiple polyA sites. [provided by RefSeq, Jul 2008]

RNA, U6 small nuclear 79, pseudogene

nuclear prelamin A recognition factor-like

RNA, U4 small nuclear 7, pseudogene

nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta

The protein encoded by this gene belongs to the NF-kappa-B inhibitor family, which inhibit NF-kappa-B by complexing with, and trapping it in the cytoplasm. Phosphorylation of serine residues on these proteins by kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B, which translocates to the nucleus to function as a transcription factor. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jul 2011]

nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, delta

nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon

The protein encoded by this gene binds to components of NF-kappa-B, trapping the complex in the cytoplasm and preventing it from activating genes in the nucleus. Phosphorylation of the encoded protein targets it for destruction by the ubiquitin pathway, which activates NF-kappa-B by making it available to translocate to the nucleus. [provided by RefSeq, Sep 2011]

nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta

This gene is a member of the ankyrin-repeat family and is induced by lipopolysaccharide (LPS). The C-terminal portion of the encoded product which contains the ankyrin repeats, shares high sequence similarity with the I kappa B family of proteins. The latter are known to play a role in inflammatory responses to LPS by their interaction with NF-B proteins through ankyrin-repeat domains. Studies in mouse indicate that this gene product is one of the nuclear I kappa B proteins and an activator of IL-6 production. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

nuclear receptor subfamily 5, group A, member 2

nuclear receptor subfamily 5, group A, member 1

The protein encoded by this gene is a transcriptional activator involved in sex determination. The encoded protein binds DNA as a monomer. Defects in this gene are a cause of XY sex reversal with or without adrenal failure as well as adrenocortical insufficiency without ovarian defect. [provided by RefSeq, Jul 2008]

RNA, U6 small nuclear 8

RNA, U6 small nuclear 9

RNA, U6 small nuclear 7

RNA, U6 small nuclear 1

RNA, U6 small nuclear 2

nuclear receptor subfamily 6, group A, member 1

This gene encodes an orphan nuclear receptor which is a member of the nuclear hormone receptor family. Its expression pattern suggests that it may be involved in neurogenesis and germ cell development. The protein can homodimerize and bind DNA, but in vivo targets have not been identified. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jun 2013]

nudC nuclear distribution protein

This gene encodes a nuclear distribution protein that plays an essential role in mitosis and cytokinesis. The encoded protein is involved in spindle formation during mitosis and in microtubule organization during cytokinesis. Pseudogenes of this gene are found on chromosome 2. [provided by RefSeq, Feb 2012]

RNA, U6 small nuclear 69, pseudogene

nuclear pore membrane glycoprotein 210-like

RNA, U1 small nuclear 20, pseudogene

heterogeneous nuclear ribonucleoprotein A1-like 2 pseudogene

gem (nuclear organelle) associated protein 8 pseudogene 2

RNA, U7 small nuclear 47 pseudogene

pirin (iron-binding nuclear protein)

This gene encodes a member of the cupin superfamily. The encoded protein is an Fe(II)-containing nuclear protein expressed in all tissues of the body and concentrated within dot-like subnuclear structures. Interactions with nuclear factor I/CCAAT box transcription factor as well as B cell lymphoma 3-encoded oncoprotein suggest the encoded protein may act as a transcriptional cofactor and be involved in the regulation of DNA transcription and replication. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008]

RNA, U7 small nuclear 86 pseudogene

nuclear receptor corepressor 1 pseudogene 2

nuclear-encoded mitochondrial transfer RNA-Gln (TTG) 8-1

RNA, U7 small nuclear 13 pseudogene

RNA, U6 small nuclear 36, pseudogene

RNA, U4atac small nuclear 2, pseudogene

nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) pseudogene 4

nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) pseudogene 1

nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) pseudogene 3

nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) pseudogene 2

heterogeneous nuclear ribonucleoprotein R

This gene encodes an RNA-binding protein that is a member of the spliceosome C complex, which functions in pre-mRNA processing and transport. The encoded protein also promotes transcription at the c-fos gene. Alternative splicing results in multiple transcript variants. There are pseudogenes for this gene on chromosomes 4, 11, and 10. [provided by RefSeq, Jul 2014]

RNA, U6 small nuclear 64, pseudogene

heterogeneous nuclear ribonucleoprotein L

Heterogeneous nuclear RNAs (hnRNAs) which include mRNA precursors and mature mRNAs are associated with specific proteins to form heterogenous ribonucleoprotein (hnRNP) complexes. Heterogeneous nuclear ribonucleoprotein L is among the proteins that are stably associated with hnRNP complexes and along with other hnRNP proteins is likely to play a major role in the formation, packaging, processing, and function of mRNA. Heterogeneous nuclear ribonucleoprotein L is present in the nucleoplasm as part of the HNRP complex. HNRP proteins have also been identified outside of the nucleoplasm. Exchange of hnRNP for mRNA-binding proteins accompanies transport of mRNA from the nucleus to the cytoplasm. Since HNRP proteins have been shown to shuttle between the nucleus and the cytoplasm, it is possible that they also have cytoplasmic functions. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

small nuclear ribonucleoprotein 200kDa (U5)

Pre-mRNA splicing is catalyzed by the spliceosome, a complex of specialized RNA and protein subunits that removes introns from a transcribed pre-mRNA segment. The spliceosome consists of small nuclear RNA proteins (snRNPs) U1, U2, U4, U5 and U6, together with approximately 80 conserved proteins. U5 snRNP contains nine specific proteins. This gene encodes one of the U5 snRNP-specific proteins. This protein belongs to the DEXH-box family of putative RNA helicases. It is a core component of U4/U6-U5 snRNPs and appears to catalyze an ATP-dependent unwinding of U4/U6 RNA duplices. Mutations in this gene cause autosomal-dominant retinitis pigmentosa. Alternatively spliced transcript variants encoding different isoforms have been found, but the full-length nature of these variants has not been determined. [provided by RefSeq, Mar 2010]

heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) pseudogene 1

nuclear ubiquitous casein and cyclin-dependent kinase substrate 1-like

poly(A) binding protein, nuclear 1-like (cytoplasmic)

heterogeneous nuclear ribonucleoprotein H1 pseudogene 2

heterogeneous nuclear ribonucleoprotein H1 pseudogene 3

heterogeneous nuclear ribonucleoprotein H1 pseudogene 1

RNA, U5B small nuclear 5, pseudogene

thymocyte nuclear protein 1

This gene encodes a protein that is highly conserved among vertebrates and plant species and may be involved in the induction of apoptosis. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

RNA, U6 small nuclear 63, pseudogene

RNA, U7 small nuclear 54 pseudogene

RNA, U5A small nuclear 2, pseudogene

nuclear transcription factor Y, beta pseudogene

nuclear-encoded mitochondrial transfer RNA-Gln (TTG) 2-1

Sjoegren syndrome nuclear autoantigen 1 homolog

nuclear factor of kappa light polypeptide gene enhancer in B-cells 1

This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)

This gene encodes a subunit of the transcription factor complex nuclear factor-kappa-B (NFkB). The NFkB complex is expressed in numerous cell types and functions as a central activator of genes involved in inflammation and immune function. The protein encoded by this gene can function as both a transcriptional activator or repressor depending on its dimerization partner. The p100 full-length protein is co-translationally processed into a p52 active form. Chromosomal rearrangements and translocations of this locus have been observed in B cell lymphomas, some of which may result in the formation of fusion proteins. There is a pseudogene for this gene on chromosome 18. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]

RNA, U7 small nuclear 32 pseudogene

basic leucine zipper nuclear factor 2 pseudogene

nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1

The product of this gene is a component of the nuclear factor of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins belonging to this family of transcription factors play a central role in inducible gene transcription during immune response. The product of this gene is an inducible nuclear component. It functions as a major molecular target for the immunosuppressive drugs such as cyclosporin A. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Different isoforms of this protein may regulate inducible expression of different cytokine genes. [provided by RefSeq, Jul 2013]

nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2

This gene is a member of the nuclear factor of activated T cells (NFAT) family. The product of this gene is a DNA-binding protein with a REL-homology region (RHR) and an NFAT-homology region (NHR). This protein is present in the cytosol and only translocates to the nucleus upon T cell receptor (TCR) stimulation, where it becomes a member of the nuclear factors of activated T cells transcription complex. This complex plays a central role in inducing gene transcription during the immune response. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Apr 2012]

nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4

This gene encodes a member of the nuclear factor of activated T cells (NFAT) protein family. The encoded protein is part of a DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor stimulation and an inducible nuclear component. NFAT proteins are activated by the calmodulin-dependent phosphatase, calcineurin. The encoded protein plays a role in the inducible expression of cytokine genes in T cells, especially in the induction of interleukin-2 and interleukin-4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

nuclear receptor interacting protein 1

Nuclear receptor interacting protein 1 (NRIP1) is a nuclear protein that specifically interacts with the hormone-dependent activation domain AF2 of nuclear receptors. Also known as RIP140, this protein modulates transcriptional activity of the estrogen receptor. [provided by RefSeq, Jul 2008]

nuclear receptor interacting protein 2

nuclear receptor interacting protein 3

poly(A) binding protein, nuclear 1 pseudogene

RNA, U7 small nuclear 33 pseudogene

RNA, U5D small nuclear 2, pseudogene

acidic (leucine-rich) nuclear phosphoprotein 32 family, member B pseudogene 2

acidic (leucine-rich) nuclear phosphoprotein 32 family, member F

acidic (leucine-rich) nuclear phosphoprotein 32 family, member D

Phosphoprotein 32 (PP32) is a tumor suppressor that can inhibit several types of cancers, including prostate and breast cancers. The protein encoded by this gene is one of at least two proteins that are similar in amino acid sequence to PP32 and are part of the same acidic nuclear phosphoprotein gene family. However, unlike PP32, the encoded protein is tumorigenic. The tumor suppressor function of PP32 has been localized to a 25 amino acid region that is absent in the protein encoded by this gene. This gene does not contain introns. [provided by RefSeq, Jul 2008]

acidic (leucine-rich) nuclear phosphoprotein 32 family, member E

acidic (leucine-rich) nuclear phosphoprotein 32 family, member B

acidic (leucine-rich) nuclear phosphoprotein 32 family, member C

Phosphoprotein 32 (PP32) is a tumor suppressor that can inhibit several types of cancers, including prostate and breast cancers. The protein encoded by this gene is one of at least two proteins that are similar in amino acid sequence to PP32 and are part of the same acidic nuclear phosphoprotein gene family. However, unlike PP32, the encoded protein is tumorigenic. The tumor suppressor function of PP32 has been localized to a 25 amino acid region that is divergent between PP32 and the protein encoded by this gene. This gene does not contain introns. [provided by RefSeq, Jul 2008]

acidic (leucine-rich) nuclear phosphoprotein 32 family, member A

CTD nuclear envelope phosphatase 1 pseudogene

cysteine-serine-rich nuclear protein 1

This gene encodes a protein that localizes to the nucleus and expression of this gene is induced in response to elevated levels of axin. The Wnt signalling pathway, which is negatively regulated by axin, is important in axis formation in early development and impaired regulation of this signalling pathway is often involved in tumors. A decreased level of expression of this gene in tumors compared to the level of expression in their corresponding normal tissues suggests that this gene product has a tumor suppressor function. [provided by RefSeq, Jul 2008]

cysteine-serine-rich nuclear protein 2

The protein encoded by this gene belongs to the CSRNP family of nuclear proteins that share conserved regions, including cysteine- and serine- rich regions, a basic domain, a transcriptional activation domain, and bind the sequence 'AGAGTG', thus have the hallmark of transcription factors. Studies in mice suggest that these genes may have redundant functions. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2011]

cysteine-serine-rich nuclear protein 3

nuclear protein, transcriptional regulator, 1

nuclear autoantigenic sperm protein (histone-binding)

This gene encodes a H1 histone binding protein that is involved in transporting histones into the nucleus of dividing cells. Multiple isoforms are encoded by transcript variants of this gene. The somatic form is expressed in all mitotic cells, is localized to the nucleus, and is coupled to the cell cycle. The testicular form is expressed in embryonic tissues, tumor cells, and the testis. In male germ cells, this protein is localized to the cytoplasm of primary spermatocytes, the nucleus of spermatids, and the periacrosomal region of mature spermatozoa. [provided by RefSeq, Jul 2008]

RNA, U6 small nuclear 76, pseudogene

RNA, U7 small nuclear 27 pseudogene

small nuclear ribonucleoprotein polypeptide C pseudogene 9

small nuclear ribonucleoprotein polypeptide C pseudogene 8

small nuclear ribonucleoprotein polypeptide C pseudogene 3

small nuclear ribonucleoprotein polypeptide C pseudogene 2

small nuclear ribonucleoprotein polypeptide C pseudogene 7

small nuclear ribonucleoprotein polypeptide C pseudogene 4

small nuclear RNA activating complex, polypeptide 3, 50kDa

small nuclear RNA activating complex, polypeptide 2, 45kDa

This gene encodes a subunit of the snRNA-activating protein complex which is associated with the TATA box-binding protein. The encoded protein is necessary for RNA polymerase II and III dependent small-nuclear RNA gene transcription. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009]

small nuclear RNA activating complex, polypeptide 1, 43kDa

small nuclear RNA activating complex, polypeptide 5, 19kDa

small nuclear RNA activating complex, polypeptide 4, 190kDa

nuclear factor interleukin-3-regulated protein-like

RNA, U6 small nuclear 21, pseudogene

nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae)

RNA, U2 small nuclear 3, pseudogene

heterogeneous nuclear ribonucleoprotein A1 pseudogene 5

heterogeneous nuclear ribonucleoprotein A1 pseudogene 4

heterogeneous nuclear ribonucleoprotein A1 pseudogene 7

heterogeneous nuclear ribonucleoprotein A1 pseudogene 1

heterogeneous nuclear ribonucleoprotein A1 pseudogene 3

heterogeneous nuclear ribonucleoprotein A1 pseudogene 2

heterogeneous nuclear ribonucleoprotein A1 pseudogene 9

heterogeneous nuclear ribonucleoprotein A1 pseudogene 8

RNA, U7 small nuclear 75 pseudogene

RNA, U7 small nuclear 4 pseudogene

RNA, 7SK small nuclear pseudogene 1

RNA, U5A small nuclear 8, pseudogene

heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they form complexes with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene contains a RNA binding domain and scaffold-associated region (SAR)-specific bipartite DNA-binding domain. This protein is also thought to be involved in the packaging of hnRNA into large ribonucleoprotein complexes. During apoptosis, this protein is cleaved in a caspase-dependent way. Cleavage occurs at the SALD site, resulting in a loss of DNA-binding activity and a concomitant detachment of this protein from nuclear structural sites. But this cleavage does not affect the function of the encoded protein in RNA metabolism. At least two alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jul 2008]

heterogeneous nuclear ribonucleoprotein K

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene is located in the nucleoplasm and has three repeats of KH domains that binds to RNAs. It is distinct among other hnRNP proteins in its binding preference; it binds tenaciously to poly(C). This protein is also thought to have a role during cell cycle progession. Several alternatively spliced transcript variants have been described for this gene, however, not all of them are fully characterized. [provided by RefSeq, Jul 2008]

heterogeneous nuclear ribonucleoprotein M

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that bind to RNAs. This protein also constitutes a monomer of the N-acetylglucosamine-specific receptor which is postulated to trigger selective recycling of immature GlcNAc-bearing thyroglobulin molecules. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]

heterogeneous nuclear ribonucleoprotein C (C1/C2)

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene can act as a tetramer and is involved in the assembly of 40S hnRNP particles. Multiple transcript variants encoding at least two different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are nucleic acid binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. It localizes to both the nucleus and the cytoplasm. This protein is implicated in the regulation of mRNA stability. Alternative splicing of this gene results in four transcript variants. [provided by RefSeq, Jul 2008]

heterogeneous nuclear ribonucleoprotein F

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins that complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and regulate alternative splicing, polyadenylation, and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that bind to RNAs which have guanosine-rich sequences. This protein is very similar to the family member hnRPH. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

RNA, U6 small nuclear 53, pseudogene

nuclear-encoded mitochondrial transfer RNA-Gln (TTG) 3-1

RNA, U6 small nuclear 39, pseudogene

RNA, U5F small nuclear 6, pseudogene

nuclear ubiquitous casein and cyclin-dependent kinase substrate 1-like

acidic (leucine-rich) nuclear phosphoprotein 32 family, member B pseudogene 1

cataract, congenital nuclear, autosomal recessive

RNA, U4 small nuclear 4, pseudogene

nuclear-encoded mitochondrial transfer RNA-Gln (TTG) 12-1

RNA, U6 small nuclear 83, pseudogene

nurim (nuclear envelope membrane protein)

The protein encoded by this gene contains transmembrane domains and resides within the inner nuclear membrane, where it is tightly associated with the nucleus. This protein shares homology with isoprenylcysteine carboxymethyltransferase enzymes. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]

RNA, U1 small nuclear 27, pseudogene

RNA, U6 small nuclear 48, pseudogene

RNA, U1 small nuclear 18, pseudogene

RNA, U2 small nuclear 1

The spliceosome is a multicomponent ribonucleoprotein complex that catalyzes the removal of introns from nuclear mRNA precursors. The spliceosome is composed of four small ribonucleoprotein particles (the U1, U2, and U4/U6 snRNPs) and numerous additional proteins. The U2 small nuclear RNA (snRNA) is a RNA component of the U2 snRNP that interacts with the 3' region of the intron at the branch site. Several sites in the human genome express U2 snRNAs. This locus represents an array of U2 snRNA genes located at 17q21-22 that undergoes concerted evolution to homogenize repeat units within the array. Each repeat in this array is approximately 6.1 kb long and contains a single copy of the U2 snRNA. Arrays of six to more than 30 repeats have been reported. [provided by RefSeq, Mar 2009]

RNA, U7 small nuclear 42 pseudogene

nuclear receptor 2C2-associated protein

RNA, U7 small nuclear 85 pseudogene

nuclear pore associated protein 1 pseudogene

RNA, U7 small nuclear 28 pseudogene

RNA, U7 small nuclear 65 pseudogene

RNA, U7 small nuclear 38 pseudogene

nuclear pore complex interacting protein pseudogene 1

heterogeneous nuclear ribonucleoprotein A1-like

heterogeneous nuclear ribonucleoprotein A1 pseudogene 19

heterogeneous nuclear ribonucleoprotein A1 pseudogene 18

heterogeneous nuclear ribonucleoprotein A1 pseudogene 15

heterogeneous nuclear ribonucleoprotein A1 pseudogene 14

heterogeneous nuclear ribonucleoprotein A1 pseudogene 17

heterogeneous nuclear ribonucleoprotein A1 pseudogene 16

heterogeneous nuclear ribonucleoprotein A1 pseudogene 11

heterogeneous nuclear ribonucleoprotein A1 pseudogene 10

heterogeneous nuclear ribonucleoprotein A1 pseudogene 13

heterogeneous nuclear ribonucleoprotein A1 pseudogene 12

spectrin repeat containing, nuclear envelope 1

This gene encodes a spectrin repeat containing protein expressed in skeletal and smooth muscle, and peripheral blood lymphocytes, that localizes to the nuclear membrane. Mutations in this gene have been associated with autosomal recessive spinocerebellar ataxia 8, also referred to as autosomal recessive cerebellar ataxia type 1 or recessive ataxia of Beauce. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

spectrin repeat containing, nuclear envelope 2

The protein encoded by this gene is a nuclear outer membrane protein that binds cytoplasmic F-actin. This binding tethers the nucleus to the cytoskeleton and aids in the maintenance of the structural integrity of the nucleus. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

spectrin repeat containing, nuclear envelope family member 3

spectrin repeat containing, nuclear envelope family member 4

nuclear-encoded mitochondrial transfer RNA-Ser (TGA) 2-1

aryl hydrocarbon receptor nuclear translocator-like

The protein encoded by this gene is a basic helix-loop-helix protein that forms a heterodimer with CLOCK. This heterodimer binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Defects in this gene have been linked to infertility, problems with gluconeogenesis and lipogenesis, and altered sleep patterns. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

nuclear pore complex interacting protein family, member A1 pseudogene

aryl-hydrocarbon receptor nuclear translocator 2

This gene encodes a member of the basic-helix-loop-helix-Per-Arnt-Sim (bHLH-PAS) superfamily of transcription factors. The encoded protein acts as a partner for several sensor proteins of the bHLH-PAS family, forming heterodimers with the sensor proteins that bind regulatory DNA sequences in genes responsive to developmental and environmental stimuli. Under hypoxic conditions, the encoded protein complexes with hypoxia-inducible factor 1alpha in the nucleus and this complex binds to hypoxia-responsive elements in enhancers and promoters of oxygen-responsive genes. A highly similar protein in mouse forms functional complexes with both aryl hydrocarbon receptors and Single-minded proteins, suggesting additional roles for the encoded protein in the metabolism of xenobiotic compounds and the regulation of neurogenesis, respectively. [provided by RefSeq, Dec 2013]

small nuclear ribonucleoprotein polypeptide B pseudogene

small nuclear ribonucleoprotein polypeptide B pseudogene

nuclear assembly factor 1 ribonucleoprotein

heterogeneous nuclear ribonucleoprotein A1 pseudogene 48

RNA, U6 small nuclear 66, pseudogene

hepatocyte nuclear factor 4, gamma pseudogene 1

gem (nuclear organelle) associated protein 7 pseudogene

RNA, U7 small nuclear 8 pseudogene

LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae) pseudogene

RNA, U7 small nuclear 14 pseudogene

heterogeneous nuclear ribonucleoprotein M pseudogene 2

heterogeneous nuclear ribonucleoprotein M pseudogene 1

nuclear receptor binding factor 2 pseudogene 4

small nuclear ribonucleoprotein polypeptide B pseudogene

nuclear-encoded mitochondrial transfer RNA-Gln (TTG) 6-1

RNA, variant U1 small nuclear 17

RNA, variant U1 small nuclear 14

RNA, variant U1 small nuclear 15

RNA, variant U1 small nuclear 11

RNA, variant U1 small nuclear 18

RNA, variant U1 small nuclear 19

RNA, U7 small nuclear 30 pseudogene

nuclear apoptosis inducing factor 1

pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2 pseudogene

nuclear protein, ataxia-telangiectasia locus

small nuclear RNA activating complex, polypeptide 5, 19kDa pseudogene 1

small nuclear ribonucleoprotein polypeptide G pseudogene 13

small nuclear ribonucleoprotein polypeptide G pseudogene 12

small nuclear ribonucleoprotein polypeptide G pseudogene 11

small nuclear ribonucleoprotein polypeptide G pseudogene 14

RNA, U5E small nuclear 8, pseudogene

nuclear transcription factor Y, gamma pseudogene

RNA, U7 small nuclear 51 pseudogene

nuclear-encoded mitochondrial transfer RNA-Gln (TTG) 13-1

C1D nuclear receptor corepressor pseudogene 2

nuclear pore complex interacting protein family, member B15

nuclear fragile X mental retardation protein interacting protein 2

nuclear fragile X mental retardation protein interacting protein 1

This gene encodes a nuclear RNA binding protein that contains a C2H2 zinc finger motif and a nuclear localization signal. This protein is associated with the nuclear matrix in perichromatin fibrils and, in neurons, localizes to the cytoplasm in association with endoplasmic reticulum ribosomes. This protein interacts with the fragile X mental retardation protein (FMRP), the tumor suppressor protein BRCA1, upregulates RNA polymerase II transcription, and is involved in box C/D snoRNP biogenesis. A pseudogene of this gene resides on chromosome 6q12. [provided by RefSeq, Feb 2012]

acidic (leucine-rich) nuclear phosphoprotein 32 family, member A pseudogene 1

heterogeneous nuclear ribonucleoprotein A1 pseudogene 54

heterogeneous nuclear ribonucleoprotein A1 pseudogene 56

nuclear receptor subfamily 3, group C, member 1 pseudogene 1

exportin, tRNA (nuclear export receptor for tRNAs) pseudogene

nuclear receptor binding SET domain protein 1

This gene encodes a protein containing a SET domain, 2 LXXLL motifs, 3 nuclear translocation signals (NLSs), 4 plant homeodomain (PHD) finger regions, and a proline-rich region. The encoded protein enhances androgen receptor (AR) transactivation, and this enhancement can be increased further in the presence of other androgen receptor associated coregulators. This protein may act as a nucleus-localized, basic transcriptional factor and also as a bifunctional transcriptional regulator. Mutations of this gene have been associated with Sotos syndrome and Weaver syndrome. One version of childhood acute myeloid leukemia is the result of a cryptic translocation with the breakpoints occurring within nuclear receptor-binding Su-var, enhancer of zeste, and trithorax domain protein 1 on chromosome 5 and nucleoporin, 98-kd on chromosome 11. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

RNA, U6 small nuclear 15, pseudogene

RNA, U2 small nuclear 4, pseudogene

RNA, U1 small nuclear 15, pseudogene

RNA, U5F small nuclear 4, pseudogene

RNA, U6atac small nuclear 3, pseudogene

nuclear-encoded mitochondrial transfer RNA-Val (TAC) 1-1

nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein

RNA, U7 small nuclear 72 pseudogene

nuclear-encoded mitochondrial transfer RNA-Leu (TAA) 4-1

RNA, U6 small nuclear 56, pseudogene

small nuclear ribonucleoprotein polypeptide G pseudogene 8

heterogeneous nuclear ribonucleoprotein A1 pseudogene 77

nuclear factor, erythroid 2-like 3 pseudogene

poly(A) binding protein, nuclear 1 pseudogene

nuclear-encoded mitochondrial transfer RNA-Leu (TAA) 5-1

MYC induced nuclear antigen

MINA is a c-Myc (MYC; MIM 190080) target gene that may play a role in cell proliferation or regulation of cell growth. (Tsuneoka et al., 2002 [PubMed 12091391]; Zhang et al., 2005 [PubMed 15897898]).[supplied by OMIM, May 2008]

RNA, U4 small nuclear 9, pseudogene

nuclear-encoded mitochondrial transfer RNA-Gln (TTG) 7-1

RNA, U6 small nuclear 71, pseudogene

RNA, U7 small nuclear 22 pseudogene

small nuclear ribonucleoprotein polypeptide B

The protein encoded by this gene associates with stem loop IV of U2 small nuclear ribonucleoprotein (U2 snRNP) in the presence of snRNP-A'. The encoded protein may play a role in pre-mRNA splicing. Autoantibodies from patients with systemic lupus erythematosus frequently recognize epitopes on the encoded protein. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

RNA, U7 small nuclear 59 pseudogene

eukaryotic translation initiation factor 4E nuclear import factor 1

The protein encoded by this gene is a nucleocytoplasmic shuttle protein for the translation initiation factor eIF4E. This shuttle protein interacts with the importin alpha-beta complex to mediate nuclear import of eIF4E. It is predominantly cytoplasmic; its own nuclear import is regulated by a nuclear localization signal and nuclear export signals. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]

RNA, U6 small nuclear 26, pseudogene

RNA, U6 small nuclear 10, pseudogene

required for meiotic nuclear division 1 homolog (S. cerevisiae) pseudogene

RNA, U7 small nuclear 41 pseudogene

RNA, U6atac small nuclear 4, pseudogene

RNA, U1 small nuclear 3

RNA, U1 small nuclear 2

RNA, U6 small nuclear 31, pseudogene

nuclear pore complex interacting protein family, member A1 pseudogene

heterogeneous nuclear ribonucleoprotein C pseudogene 9

heterogeneous nuclear ribonucleoprotein C pseudogene 8

heterogeneous nuclear ribonucleoprotein C pseudogene 7

heterogeneous nuclear ribonucleoprotein C pseudogene 6

heterogeneous nuclear ribonucleoprotein C pseudogene 1

heterogeneous nuclear ribonucleoprotein C pseudogene 3

SP100 nuclear antigen

This gene encodes a subnuclear organelle and major component of the PML (promyelocytic leukemia)-SP100 nuclear bodies. PML and SP100 are covalently modified by the SUMO-1 modifier, which is considered crucial to nuclear body interactions. The encoded protein binds heterochromatin proteins and is thought to play a role in tumorigenesis, immunity, and gene regulation. Alternatively spliced variants have been identified for this gene; one of which encodes a high-mobility group protein. [provided by RefSeq, Aug 2011]

nuclear receptor binding protein 2

nuclear receptor binding protein 1

RNA, U7 small nuclear 60 pseudogene

heterogeneous nuclear ribonucleoprotein A1 pseudogene 64

heterogeneous nuclear ribonucleoprotein A1 pseudogene 66

heterogeneous nuclear ribonucleoprotein A1 pseudogene 67

heterogeneous nuclear ribonucleoprotein A1 pseudogene 60

heterogeneous nuclear ribonucleoprotein A1 pseudogene 61

nuclear receptor subfamily 2, group E, member 1

nuclear receptor subfamily 2, group E, member 3

This protein is part of a large family of nuclear receptor transcription factors involved in signaling pathways. Nuclear receptors have been shown to regulate pathways involved in embryonic development, as well as in maintenance of proper cell function in adults. Members of this family are characterized by discrete domains that function in DNA and ligand binding. This gene encodes a retinal nuclear receptor that is a ligand-dependent transcription factor. Defects in this gene are a cause of enhanced S cone syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

U2 small nuclear RNA auxiliary factor 1-like 4 pseudogene

RNA, U5B small nuclear 3, pseudogene

small nuclear ribonucleoprotein 40kDa (U5)

This gene encodes a component of the U5 small nuclear ribonucleoprotein (snRNP) particle. The U5 snRNP is part of the spliceosome, a multiprotein complex that catalyzes the removal of introns from pre-messenger RNAs. [provided by RefSeq, Jul 2008]

small nuclear ribonucleoprotein 48kDa (U11/U12)

nuclear factor of activated T-cells 5, tonicity-responsive

The product of this gene is a member of the nuclear factors of activated T cells family of transcription factors. Proteins belonging to this family play a central role in inducible gene transcription during the immune response. This protein regulates gene expression induced by osmotic stress in mammalian cells. Unlike monomeric members of this protein family, this protein exists as a homodimer and forms stable dimers with DNA elements. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

RNA, U1 small nuclear 22, pseudogene

gem (nuclear organelle) associated protein 7

The protein encoded by this gene is a component of the core SMN complex, which is required for pre-mRNA splicing in the nucleus. The encoded protein is found in the nucleoplasm, in nuclear "gems" (Gemini of Cajal bodies), and in the cytoplasm. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

RNA, 7SK small nuclear pseudogene 8

RNA, 7SK small nuclear pseudogene 9

RNA, 7SK small nuclear pseudogene 6

RNA, 7SK small nuclear pseudogene 7

RNA, 7SK small nuclear pseudogene 4

RNA, 7SK small nuclear pseudogene 5

RNA, 7SK small nuclear pseudogene 2

RNA, 7SK small nuclear pseudogene 3

RNA, U7 small nuclear 80 pseudogene

nuclear pore associated protein 1 pseudogene 1

nuclear pore associated protein 1 pseudogene 3

nuclear pore associated protein 1 pseudogene 2

nuclear pore associated protein 1 pseudogene 4

nuclear pore associated protein 1 pseudogene 6

nuclear pore associated protein 1 pseudogene 8

PEST containing nuclear protein pseudogene 3

PEST containing nuclear protein pseudogene 1

PEST containing nuclear protein pseudogene 5

PEST containing nuclear protein pseudogene 4

RNA, U7 small nuclear 11 pseudogene

RNA, U7 small nuclear 35 pseudogene

RNA, U7 small nuclear 68 pseudogene

nuclear receptor coactivator 4 pseudogene

nuclear transcription factor Y, beta pseudogene

nuclear protein, transcriptional regulator, 1-like

RNA, U7 small nuclear 52 pseudogene

RNA, U5A small nuclear 4, pseudogene

gem (nuclear organelle) associated protein 8

The protein encoded by this gene is part of the SMN complex, which is necessary for spliceosomal snRNP assembly in the cytoplasm and pre-mRNA splicing in the nucleus. The encoded protein binds to both SMN1 and the GEMIN6/GEMIN7 heterodimer, mediating their interaction. This protein is found in nuclear Gemini of Cajal bodies (gems) and in the cytoplasm. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, May 2010]

gem (nuclear organelle) associated protein 2

This gene encodes one of the proteins found in the SMN complex, which consists of several gemin proteins and the protein known as the survival of motor neuron protein. The SMN complex is localized to a subnuclear compartment called gems (gemini of coiled bodies) and is required for assembly of spliceosomal snRNPs and for pre-mRNA splicing. This protein interacts directly with the survival of motor neuron protein and it is required for formation of the SMN complex. A knockout mouse targeting the mouse homolog of this gene exhibited disrupted snRNP assembly and motor neuron degeneration. [provided by RefSeq, Aug 2011]

gem (nuclear organelle) associated protein 6

GEMIN6 is part of a large macromolecular complex, localized to both the cytoplasm and the nucleus, that plays a role in the cytoplasmic assembly of small nuclear ribonucleoproteins (snRNPs). Other members of this complex include SMN (MIM 600354), GEMIN2 (SIP1; MIM 602595), GEMIN3 (DDX20; MIM 606168), GEMIN4 (MIM 606969), and GEMIN5 (MIM 607005).[supplied by OMIM, Jul 2002]

gem (nuclear organelle) associated protein 4

The product of this gene is part of a large complex localized to the cytoplasm, nucleoli, and to discrete nuclear bodies called Gemini bodies (gems). The complex functions in spliceosomal snRNP assembly in the cytoplasm, and regenerates spliceosomes required for pre-mRNA splicing in the nucleus. The encoded protein directly interacts with a DEAD box protein and several spliceosome core proteins. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

gem (nuclear organelle) associated protein 5

This gene encodes a WD repeat protein that is a component of the survival of motor neurons (SMN) complex. The SMN complex plays a critical role in mRNA splicing through the assembly of spliceosomal small nuclear ribonucleoproteins (snRNPs), and may also mediate the assembly and transport of other classes of ribonucleoproteins. The encoded protein is the snRNA-binding component of the SMN complex. Dysregulation of this gene may play a role in alternative mRNA splicing and tumor cell motility. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

RALY heterogeneous nuclear ribonucleoprotein

This gene encodes a member of the heterogeneous nuclear ribonucleoprotein (hnRNP) gene family. This protein may play a role in pre-mRNA splicing and in embryonic development. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]

RNA, U6 small nuclear 45, pseudogene

nuclear transcription factor, X-box binding-like 1

RNA, U6 small nuclear 34, pseudogene

nuclear RNA export factor 4 pseudogene

nuclear RNA export factor 5

This gene is one member of a family of nuclear RNA export factor genes. The encoded protein can bind RNA, and is implicated in mRNA nuclear export. However, this protein has lost several C-terminal protein domains found in other family members that are required for export activity, and may be an evolving pseudogene. Alternatively spliced transcript variants have been described, but most are candidates for nonsense-mediated decay (NMD) and may not express proteins in vivo. [provided by RefSeq, Jul 2009]

nuclear RNA export factor 1

This gene is one member of a family of nuclear RNA export factor genes. Common domain features of this family are a noncanonical RNP-type RNA-binding domain (RBD), 4 leucine-rich repeats (LRRs), a nuclear transport factor 2 (NTF2)-like domain that allows heterodimerization with NTF2-related export protein-1 (NXT1), and a ubiquitin-associated domain that mediates interactions with nucleoporins. The LRRs and NTF2-like domains are required for export activity. Alternative splicing seems to be a common mechanism in this gene family. The encoded protein of this gene shuttles between the nucleus and the cytoplasm and binds in vivo to poly(A)+ RNA. It is the vertebrate homologue of the yeast protein Mex67p. The encoded protein overcomes the mRNA export block caused by the presence of saturating amounts of CTE (constitutive transport element) RNA of type D retroviruses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]

nuclear RNA export factor 2

This gene encodes a member of a family of nuclear RNA export proteins. The encoded protein is associated with the nuclear envelope and aids in the export of mRNAs. There is a closely related paralog of this gene located adjacent on chromosome X and on the opposite strand. [provided by RefSeq, Aug 2013]

nuclear RNA export factor 3

This gene is one member of a family of nuclear RNA export factor genes. Common domain features of this family are a noncanonical RNP-type RNA-binding domain (RBD), 4 leucine-rich repeats (LRRs), a nuclear transport factor 2 (NTF2)-like domain that allows heterodimerization with NTF2-related export protein-1 (NXT1), and a ubiquitin-associated domain that mediates interactions with nucleoporins. The LRRs and NTF2-like domains are required for export activity. Alternative splicing seems to be a common mechanism in this gene family. The encoded protein of this gene has shortened LRR and ubiquitin-associated domains and its RDB is unable to bind RNA. It is located in the nucleoplasm but is not associated with either the nuclear envelope or the nucleolus. [provided by RefSeq, Jul 2008]

gem (nuclear organelle) associated protein 8 pseudogene 4

gem (nuclear organelle) associated protein 8 pseudogene 3

LSM1, U6 small nuclear RNA associated pseudogene 1

RNA, U6 small nuclear 55, pseudogene

nuclear pore complex interacting protein family, member B5

RNA, U5F small nuclear 7, pseudogene

heterogeneous nuclear ribonucleoprotein H1 (H)

This gene encodes a member of a subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins that complex with heterogeneous nuclear RNA. These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some may shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that bind to RNA and is very similar to the family member HNRPF. This gene may be associated with hereditary lymphedema type I. Alternatively spliced transcript variants have been described [provided by RefSeq, Mar 2012]

heterogeneous nuclear ribonucleoprotein H3 (2H9)

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. It is localized in nuclear bodies of the nucleus. This protein is involved in the splicing process and it also participates in early heat shock-induced splicing arrest by transiently leaving the hnRNP complexes. Several alternatively spliced transcript variants have been noted for this gene, however, not all are fully characterized. [provided by RefSeq, Jul 2008]

heterogeneous nuclear ribonucleoprotein H2 (H')

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that binds to RNAs. It is very similar to the family member HNRPH1. This gene is thought to be involved in Fabray disease and X-linked agammaglobulinemia phenotype. Alternative splicing results in multiple transcript variants encoding the same protein. Read-through transcription between this locus and the ribosomal protein L36a gene has been observed. [provided by RefSeq, Jan 2011]

RNA, U7 small nuclear 19 pseudogene

RNA, U7 small nuclear 78 pseudogene

heterogeneous nuclear ribonucleoprotein U-like 2

heterogeneous nuclear ribonucleoprotein U-like 1

This gene encodes a nuclear RNA-binding protein of the heterogeneous nuclear ribonucleoprotein (hnRNP) family. This protein binds specifically to adenovirus E1B-55kDa oncoprotein. It may play an important role in nucleocytoplasmic RNA transport, and its function is modulated by E1B-55kDa in adenovirus-infected cells. Two transcript variants encoding different isoforms have been found for this gene. Additional variants have also been found, but their full-length natures have not been determined. [provided by RefSeq, Jul 2008]

RNA, U4atac small nuclear (U12-dependent splicing)

The small nuclear RNA (snRNA) encoded by this gene is part of the U12-dependent minor spliceosome complex. In addition to the encoded RNA, this ribonucleoprotein complex consists of U11, U12, U5, and U6atac snRNAs. The U12-dependent spliceosome acts on approximately 700 specific introns in the human genome. Defects in this gene are a cause of microcephalic osteodysplastic primordial dwarfism type 1 (MOPD). [provided by RefSeq, Jul 2011]

nuclear pore complex interacting protein pseudogene

RNA, U7 small nuclear 25 pseudogene

nuclear fragile X mental retardation protein interacting protein 1 pseudogene

C1D nuclear receptor corepressor pseudogene 4

gem (nuclear organelle) associated protein 8 pseudogene 1

RNA, U7 small nuclear 81 pseudogene

RNA, U6 small nuclear 23, pseudogene

RNA, U7 small nuclear 10 pseudogene

RNA, U7 small nuclear 20 pseudogene

proliferating cell nuclear antigen pseudogene 2

RNA, U7 small nuclear 6 pseudogene

RNA, U7 small nuclear 77 pseudogene

nuclear factor related to kappaB binding protein

nuclear transcription factor, X-box binding 1

MHC class II gene expression is controlled primarily at the transcriptional level by transcription factors that bind to the X and Y boxes, two highly conserved elements in the proximal promoter of MHC class II genes. The protein encoded by this gene is a transcriptional repressor capable of binding to the conserved X box motif of HLA-DRA and other MHC class II genes in vitro. The protein may play a role in regulating the duration of an inflammatory response by limiting the period in which class II MHC molecules are induced by IFN-gamma. Three alternative splice variants, each of which encodes a different isoform, have been identified. [provided by RefSeq, Jul 2008]

RNA, 7SK small nuclear

pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2

nuclear-encoded mitochondrial transfer RNA-Ser (TGA) 1-1

heterogeneous nuclear ribonucleoprotein A1 pseudogene

nuclear factor, erythroid 4

The erythroid-specific protein encoded by this gene, and the ubiquitous transcription factor CP2, form the stage selector protein (SSP) complex, which is involved in preferential expression of the gamma-globin genes in fetal erythroid cells. Alternate use of an in-frame upstream non-AUG (CUG) translation initiation codon, and a downstream AUG codon, results in two isoforms. While the long isoform (22 kDa) acts as an activator, the short isoform (14 kDa) has been shown to repress gamma-globin gene expression. This gene is located in an intron of the FBXL13 gene on the opposite strand. [provided by RefSeq, Jul 2008]

nuclear factor, erythroid 2

poly(A) binding protein, nuclear 1

This gene encodes an abundant nuclear protein that binds with high affinity to nascent poly(A) tails. The protein is required for progressive and efficient polymerization of poly(A) tails at the 3' ends of eukaryotic transcripts and controls the size of the poly(A) tail to about 250 nt. At steady-state, this protein is localized in the nucleus whereas a different poly(A) binding protein is localized in the cytoplasm. This gene contains a GCG trinucleotide repeat at the 5' end of the coding region, and expansion of this repeat from the normal 6 copies to 8-13 copies leads to autosomal dominant oculopharyngeal muscular dystrophy (OPMD) disease. Related pseudogenes have been identified on chromosomes 19 and X. Read-through transcription also exists between this gene and the neighboring upstream BCL2-like 2 (BCL2L2) gene. [provided by RefSeq, Dec 2010]

nuclear receptor subfamily 2, group F, member 6

nuclear receptor subfamily 2, group F, member 1

The protein encoded by this gene is a nuclear hormone receptor and transcriptional regulator. The encoded protein acts as a homodimer and binds to 5'-AGGTCA-3' repeats. Defects in this gene are a cause of Bosch-Boonstra optic atrophy syndrome (BBOAS). [provided by RefSeq, Apr 2014]

nuclear receptor subfamily 2, group F, member 2

This gene encodes a member of the steroid thyroid hormone superfamily of nuclear receptors. The encoded protein is a ligand inducible transcription factor that is involved in the regulation of many different genes. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]

RNA, U5D small nuclear 1

translocated promoter region, nuclear basket protein

This gene encodes a large coiled-coil protein that forms intranuclear filaments attached to the inner surface of nuclear pore complexes (NPCs). The protein directly interacts with several components of the NPC. It is required for the nuclear export of mRNAs and some proteins. Oncogenic fusions of the 5' end of this gene with several different kinase genes occur in some neoplasias. [provided by RefSeq, Jul 2008]

RNA, U4 small nuclear 6, pseudogene

SET nuclear proto-oncogene

The protein encoded by this gene inhibits acetylation of nucleosomes, especially histone H4, by histone acetylases (HAT). This inhibition is most likely accomplished by masking histone lysines from being acetylated, and the consequence is to silence HAT-dependent transcription. The encoded protein is part of a complex localized to the endoplasmic reticulum but is found in the nucleus and inhibits apoptosis following attack by cytotoxic T lymphocytes. This protein can also enhance DNA replication of the adenovirus genome. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

heterogeneous nuclear ribonucleoprotein C pseudogene 10

LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae) pseudogene

CTD nuclear envelope phosphatase 1

nuclear-encoded mitochondrial transfer RNA-Gln (TTG) 11-1

small nuclear ribonucleoprotein 70kDa (U1)

nuclear mitotic apparatus protein 1

This gene encodes a large protein that forms a structural component of the nuclear matrix. The encoded protein interacts with microtubules and plays a role in the formation and organization of the mitotic spindle during cell division. Chromosomal translocation of this gene with the RARA (retinoic acid receptor, alpha) gene on chromosome 17 have been detected in patients with acute promyelocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]

RNA, U7 small nuclear 49 pseudogene

RNA, U5E small nuclear 1

RNA, U1 small nuclear 21, pseudogene

proline-rich nuclear receptor coactivator 2 pseudogene

RNA, U7 small nuclear 44 pseudogene

nuclear receptor subfamily 4, group A, member 2

This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcription factor. Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson disease, schizophernia, and manic depression. Misregulation of this gene may be associated with rheumatoid arthritis. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

nuclear receptor subfamily 4, group A, member 3

This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcriptional activator. The protein can efficiently bind the NGFI-B Response Element (NBRE). Three different versions of extraskeletal myxoid chondrosarcomas (EMCs) are the result of reciprocal translocations between this gene and other genes. The translocation breakpoints are associated with Nuclear Receptor Subfamily 4, Group A, Member 3 (on chromosome 9) and either Ewing Sarcome Breakpoint Region 1 (on chromosome 22), RNA Polymerase II, TATA Box-Binding Protein-Associated Factor, 68-KD (on chromosome 17), or Transcription factor 12 (on chromosome 15). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]

nuclear receptor subfamily 4, group A, member 1

This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. Expression is induced by phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. The encoded protein acts as a nuclear transcription factor. Translocation of the protein from the nucleus to mitochondria induces apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]

tumor protein p53 inducible nuclear protein 1

tumor protein p53 inducible nuclear protein 2

RNA, U7 small nuclear 87 pseudogene

nuclear speckle splicing regulatory protein 1 pseudogene 1

RNA, U7 small nuclear 12 pseudogene

RNA, U6atac small nuclear (U12-dependent splicing)

heterogeneous nuclear ribonucleoprotein A1 pseudogene 37

heterogeneous nuclear ribonucleoprotein A1 pseudogene 36

heterogeneous nuclear ribonucleoprotein A1 pseudogene 35

heterogeneous nuclear ribonucleoprotein A1 pseudogene 34

heterogeneous nuclear ribonucleoprotein A1 pseudogene 33

heterogeneous nuclear ribonucleoprotein A1 pseudogene 39

heterogeneous nuclear ribonucleoprotein A1pseudogene 38

nuclear-encoded mitochondrial transfer RNA-Leu (TAA) 3-1

RNA, U5B small nuclear 6, pseudogene

RNA, U7 small nuclear 57 pseudogene

RNA, U6 small nuclear 52, pseudogene

heterogeneous nuclear ribonucleoprotein A1 pseudogene 43

heterogeneous nuclear ribonucleoprotein A3 pseudogene

nuclear receptor binding factor 2 pseudogene 1

nuclear receptor binding factor 2 pseudogene 3

nuclear receptor binding factor 2 pseudogene 2

nuclear export mediator factor

RNA, U7 small nuclear 88 pseudogene

nuclear pore complex-interacting protein family member B4-like

nuclear-encoded mitochondrial transfer RNA-Gln (TTG) 10-1

RNA, 7SK small nuclear pseudogene 10

heterogeneous nuclear ribonucleoprotein L pseudogene 2

heterogeneous nuclear ribonucleoprotein L pseudogene 1

nuclear receptor corepressor 1 pseudogene 1

nuclear receptor corepressor 1 pseudogene 3

small nuclear ribonucleoprotein polypeptide A' pseudogene

RNA, U6 small nuclear 58, pseudogene

RNA, U5E small nuclear 9, pseudogene

C1D nuclear receptor corepressor

The protein encoded by this gene is a DNA binding and apoptosis-inducing protein and is localized in the nucleus. It is also a Rac3-interacting protein which acts as a corepressor for the thyroid hormone receptor. This protein is thought to regulate TRAX/Translin complex formation. Alternate splicing results in multiple transcript variants that encode the same protein. Multiple pseudogenes of this gene are found on chromosome 10.[provided by RefSeq, Jun 2010]

nuclear pore complex interacting protein family, member A8

nuclear pore complex interacting protein family, member A5

nuclear pore complex interacting protein family, member A7

nuclear pore complex interacting protein family, member A1

nuclear pore complex interacting protein family, member A2

nuclear pore complex interacting protein family, member A3

RNA, U7 small nuclear 73 pseudogene

RNA, U6 small nuclear variant sequence with SNRPE pseudogene sequence

RNA, U5E small nuclear 5, pseudogene

small nuclear ribonucleoprotein polypeptide G pseudogene 10

small nuclear ribonucleoprotein polypeptide G pseudogene 15

nuclear-encoded mitochondrial transfer RNA-Gln (TTG) 9-1

RNA, U1 small nuclear 17, pseudogene

RNA, U2 small nuclear 2, pseudogene

RNA, U5F small nuclear 2, pseudogene

RNA, U7 small nuclear 74 pseudogene

Mdm1 nuclear protein homolog (mouse)

This gene encodes a nuclear protein similar to the mouse double minute 1 protein. The mouse gene is located in double minute (DM) chromatin particles, is amplified in the mouse transformed 3T3 cell line, and the encoded protein is able to bind to p53. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]

RNA, U6 small nuclear 50, pseudogene

aryl hydrocarbon receptor nuclear translocator-like 2

This gene encodes a basic helix-loop-helix transcription factor belonging to the PAS (PER, ARNT, SIM) superfamily. The PAS proteins play important roles in adaptation to low atmospheric and cellular oxygen levels, exposure to certain environmental pollutants, and diurnal oscillations in light and temperature. This protein forms a transcriptionally active heterodimer with the circadian CLOCK protein, the structurally related MOP4, and hypoxia-inducible factors, such as HIF1alpha. Consistent with its role as a biologically relevant partner of circadian and hypoxia factors, this protein is coexpressed in regions of the brain such as the thalamus, hypothalamus, and amygdala. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]

exportin, tRNA (nuclear export receptor for tRNAs) pseudogene

Cataract, congenital, nuclear progressive

proline-rich nuclear receptor coactivator 1

proline-rich nuclear receptor coactivator 2

RNA, U5E small nuclear 2, pseudogene

nuclear-encoded mitochondrial transfer RNA-Leu (TAA) 6-1

small nuclear ribonucleoprotein 25kDa (U11/U12)

Two types of spliceosomes catalyze splicing of pre-mRNAs. The major U2-type spliceosome is found in all eukaryotes and removes U2-type introns, which represent more than 99% of pre-mRNA introns. The minor U12-type spliceosome is found in some eukaryotes and removes U12-type introns, which are rare and have distinct splice consensus signals. The U12-type spliceosome consists of several small nuclear RNAs and associated proteins. This gene encodes a 25K protein that is a component of the U12-type spliceosome. [provided by RefSeq, Apr 2010]

small nuclear ribonucleoprotein 27kDa (U4/U6.U5)

This gene encodes a serine/arginine-rich (SR) protein. SR proteins play important roles in pre-mRNA splicing by facilitating the recognition and selection of splice sites. The encoded protein associates with the 25S U4/U6.U5 tri-snRNP, a major component of the U2-type spiceosome. The expression of this gene may be altered in cells infected with the human T-cell lymphotropic virus type 1 (HTLV-1) retrovirus. A pseudogene of this gene is located on the long arm of chromosome 5. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Feb 2011]

ligand dependent nuclear receptor corepressor

LCOR is a transcriptional corepressor widely expressed in fetal and adult tissues that is recruited to agonist-bound nuclear receptors through a single LxxLL motif, also referred to as a nuclear receptor (NR) box (Fernandes et al., 2003 [PubMed 12535528]).[supplied by OMIM, Mar 2008]

RNA, U6 small nuclear 82, pseudogene

RNA, U1 small nuclear 24, pseudogene

nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1

This gene encodes a divergent member of the I-kappa-B family of proteins. Its function has not been determined. The gene lies within the major histocompatibility complex (MHC) class I region on chromosome 6. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2009]

RNA, U7 small nuclear 43 pseudogene

meiosis-specific nuclear structural 1

This gene encodes a protein highly similar to the mouse meiosis-specific nuclear structural 1 protein. The mouse protein was shown to be expressed at the pachytene stage during spermatogenesis and may function as a nuclear skeletal protein to regulate nuclear morphology during meiosis. [provided by RefSeq, Oct 2008]

nuclear transport factor 2-like export factor 2

The protein encoded by this gene contains a nuclear transport factor 2 (NTF2) domain, which plays an important role in the trafficking of macromolecules, ions, and small molecules between the cytoplasm and nucleus. This protein may also have a role in mRNA nuclear export. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jun 2011]

nuclear transport factor 2-like export factor 1

The protein encoded by this gene is located in the nuclear envelope. It has protein similarity to nuclear transport factor 2. This protein functions as a nuclear export factor in both RAN (Ras-related nuclear protein)- and CRM1 (required for chromosome region maintenance)-dependent pathways. It is found to stimulate the export of U1 snRNA in RAN- and CRM1-dependent pathways and the export of tRNA and mRNA in a CRM1-independent pathway. The encoded protein heterodimerizes with Tap protein and may regulate the ability of Tap protein to mediate nuclear mRNA export. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq, Jul 2008]

nuclear receptor coactivator 4 pseudogene 1

RNA, U7 small nuclear 66 pseudogene

nuclear receptor subfamily 2, group C, member 2

This gene encodes a protein that belongs to the nuclear hormone receptor family. Members of this family act as ligand-activated transcription factors and function in many biological processes such as development, cellular differentiation and homeostasis. The activated receptor/ligand complex is translocated to the nucleus where it binds to hormone response elements of target genes. The protein encoded by this gene plays a role in protecting cells from oxidative stress and damage induced by ionizing radiation. The lack of a similar gene in mouse results in growth retardation, severe spinal curvature, subfertility, premature aging, and prostatic intraepithelial neoplasia (PIN) development. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2014]

nuclear receptor subfamily 2, group C, member 1

This gene encodes a nuclear hormone receptor characterized by a highly conserved DNA binding domain (DBD), a variable hinge region, and a carboxy-terminal ligand binding domain (LBD) that is typical for all members of the steroid/thyroid hormone receptor superfamily. This protein also belongs to a large family of ligand-inducible transcription factors that regulate gene expression by binding to specific DNA sequences within promoters of target genes. Multiple alternatively spliced transcript variants have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]

RNA, U6 small nuclear 19, pseudogene

RNA, U4 small nuclear 3, pseudogene

nuclear GTPase, germinal center associated

nuclear RNA export factor 3 pseudogene

RNA, U6 small nuclear 16, pseudogene

RNA, U7 small nuclear 9 pseudogene

nuclear speckle splicing regulatory protein 1-like

heterogeneous nuclear ribonucleoprotein A1-like 2

nuclear receptor coactivator 4 pseudogene

nuclear cap binding protein subunit 1, 80kDa

The product of this gene is a component of the nuclear cap-binding protein complex (CBC), which binds to the monomethylated 5' cap of nascent pre-mRNA in the nucleoplasm. The encoded protein promotes high-affinity mRNA-cap binding and associates with the CTD of RNA polymerase II. The CBC promotes pre-mRNA splicing, 3'-end processing, RNA nuclear export, and nonsense-mediated mRNA decay. [provided by RefSeq, Jul 2008]

nuclear cap binding protein subunit 2, 20kDa

The product of this gene is a component of the nuclear cap-binding protein complex (CBC), which binds to the monomethylated 5' cap of nascent pre-mRNA in the nucleoplasm. The encoded protein has an RNP domain commonly found in RNA binding proteins, and contains the cap-binding activity. The CBC promotes pre-mRNA splicing, 3'-end processing, RNA nuclear export, and nonsense-mediated mRNA decay. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

RNA, U7 small nuclear 82 pseudogene

RNA, U7 small nuclear 17 pseudogene

U2 small nuclear RNA auxiliary factor 1-like 4 pseudogene

ligand dependent nuclear receptor corepressor-like

This gene encodes a transcription factor that appears to function in spermatogenesis. Polymorphisms in this gene are associated with measures of skeletal frame size and adult height. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

RNA, U6 small nuclear 6, pseudogene

nuclear-encoded mitochondrial transfer RNA-Pro (TGG) 1-1

RNA, variant U1 small nuclear 20

nuclear pore complex-interacting protein family member B7-like

nuclear receptor binding factor 2

RNA, U4 small nuclear 1

RNA, U7 small nuclear 37 pseudogene

nuclear receptor corepressor 2

This gene encodes a nuclear receptor co-repressor that mediates transcriptional silencing of certain target genes. The encoded protein is a member of a family of thyroid hormone- and retinoic acid receptor-associated co-repressors. This protein acts as part of a multisubunit complex which includes histone deacetylases to modify chromatin structure that prevents basal transcriptional activity of target genes. Aberrant expression of this gene is associated with certain cancers. Alternate splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Apr 2011]

nuclear receptor corepressor 1

This gene encodes a protein that mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. This gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 17 and 20.[provided by RefSeq, Jun 2010]

heterogeneous nuclear ribonucleoprotein A3 pseudogene 16

heterogeneous nuclear ribonucleoprotein A3 pseudogene 14

heterogeneous nuclear ribonucleoprotein A3 pseudogene 13

heterogeneous nuclear ribonucleoprotein A3 pseudogene 12

heterogeneous nuclear ribonucleoprotein A3 pseudogene 11

heterogeneous nuclear ribonucleoprotein A3 pseudogene 10

small nuclear ribonucleoprotein polypeptide B pseudogene

RNA, U7 small nuclear 18 pseudogene

nuclear factor, erythroid 2-like 3 pseudogene 1

nuclear pore associated protein 1 pseudogene 5

RNA, U1 small nuclear 14, pseudogene

small nuclear ribonucleoprotein polypeptide A' pseudogene

heterogeneous nuclear ribonucleoprotein A1 pseudogene 29

RNA, U6atac small nuclear 2, pseudogene

RNA, U5F small nuclear 5, pseudogene

small nuclear ribonucleoprotein polypeptide A'

RNA, U7 small nuclear 71 pseudogene

heterogeneous nuclear ribonucleoprotein D-like pseudogene 4

pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha

This gene encodes a member of the pterin-4-alpha-carbinolamine dehydratase family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. The encoded protein functions as both a dehydratase involved in tetrahydrobiopterin biosynthesis, and as a cofactor for HNF1A-dependent transcription. A deficiency of this enzyme leads to hyperphenylalaninemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

RNA, variant U1 small nuclear 3

poly(A) binding protein, nuclear 1 pseudogene

RNA, U6 small nuclear 68, pseudogene

RNA, U6 small nuclear 57, pseudogene

basic leucine zipper nuclear factor 1

proline-rich nuclear receptor coactivator 2 pseudogene

LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae)

Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM, Apr 2004]

LSM1, U6 small nuclear RNA associated

This gene encodes a member of the LSm family of RNA-binding proteins. LSm proteins form stable heteromers that bind specifically to the 3'-terminal oligo(U) tract of U6 snRNA and may play a role in pre-mRNA splicing by mediating U4/U6 snRNP formation. Increased expression of this gene may play a role in cellular transformation and the progression of several malignancies including lung cancer, mesothelioma and breast cancer. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, Nov 2011]

LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae)

This gene encodes a member of the LSm family of RNA-binding proteins. LSm proteins form stable heteromers that bind specifically to the 3'-terminal oligo(U) tract of U6 snRNA and may play a role in pre-mRNA splicing by mediating U4/U6 snRNP formation. Pseudogenes of this gene are located on the short arm of chromosomes 6 and 19. [provided by RefSeq, Nov 2011]

RNA, U6 small nuclear 72, pseudogene

nuclear paraspeckle assembly transcript 1 (non-protein coding)

This gene produces a long non-coding RNA (lncRNA) transcribed from the multiple endocrine neoplasia locus. This lncRNA is retained in the nucleus where it forms the core structural component of the paraspeckle sub-organelles. It may act as a transcriptional regulator for numerous genes, including some genes involved in cancer progression. [provided by RefSeq, Mar 2015]

RNA, U5E small nuclear 7, pseudogene

RNA, U12 small nuclear

RNA, U11 small nuclear

RNA, U4 small nuclear 8, pseudogene

RNA, U7 small nuclear 58 pseudogene

RNA, U5A small nuclear 7, pseudogene

RNA, U7 small nuclear 23 pseudogene

dendritic cell-associated nuclear protein

This intronless gene is specifically expressed in dendritic cells (DCs), which are potent antigen-presenting cells involved in activating naive T cells to initiate antigen-specific immune response. The encoded protein is localized mainly in the perinucleus. One of the alleles (A/T) of this gene, that causes premature translation termination at aa 117, has been associated with an increased prevalence of major depression in humans. [provided by RefSeq, Jul 2008]

nuclear receptor subfamily 1, group H, member 5, pseudogene

small nuclear ribonucleoprotein polypeptide E pseudogene 9

small nuclear ribonucleoprotein polypeptide E pseudogene 8

small nuclear ribonucleoprotein polypeptide E pseudogene 5

small nuclear ribonucleoprotein polypeptide E pseudogene 4

small nuclear ribonucleoprotein polypeptide E pseudogene 7

small nuclear ribonucleoprotein polypeptide E pseudogene 6

small nuclear ribonucleoprotein polypeptide E pseudogene 1

small nuclear ribonucleoprotein polypeptide E pseudogene 3

small nuclear ribonucleoprotein polypeptide E pseudogene 2

heterogeneous nuclear ribonucleoprotein A3 pseudogene 6

heterogeneous nuclear ribonucleoprotein A3 pseudogene 5

small nuclear ribonucleoprotein polypeptide C pseudogene 1

nuclear receptor binding factor 2 pseudogene

RNA, U7 small nuclear 89 pseudogene

nuclear-encoded mitochondrial transfer RNA-Leu (TAA) 2-1

heterogeneous nuclear ribonucleoprotein A1 pseudogene

RNA, U7 small nuclear 61 pseudogene

heterogeneous nuclear ribonucleoprotein A1 pseudogene 51

heterogeneous nuclear ribonucleoprotein A1 pseudogene 53

heterogeneous nuclear ribonucleoprotein A1 pseudogene 52

heterogeneous nuclear ribonucleoprotein A1 pseudogene 55

heterogeneous nuclear ribonucleoprotein A1 pseudogene 58

RNA, U7 small nuclear 63 pseudogene

small nuclear ribonucleoprotein polypeptide G pseudogene 2

RNA, U12 small nuclear 2, pseudogene

nuclear pore associated protein 1

This gene is located in the Prader-Willi syndrome region on chromosome 15. This gene is biallelically expressed in adult testis and brain but is paternally imprinted in fetal brain. Defects in this gene may be associated with Prader-Willi syndrome. [provided by RefSeq, Aug 2012]

nuclear receptor subfamily 1, group H, member 4

This gene encodes a ligand-activated transcription factor, which shares structural features in common with nuclear hormone receptor family, such as a DNA-binding domain that targets the receptor to specific DNA sequences, and a ligand-binding domain, which interacts directly with the ligand and contains a ligand-dependent transcriptional activation domain. This protein functions as a receptor for bile acids, and when bound to bile acids, regulates the expression of genes involved in bile acid synthesis and transport. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]

nuclear receptor subfamily 1, group H, member 2

The liver X receptors, LXRA (NR1H3; MIM 602423) and LXRB, form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. The inducible LXRA is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRB is ubiquitously expressed. Ligand-activated LXRs form obligate heterodimers with retinoid X receptors (RXRs; see MIM 180245) and regulate expression of target genes containing LXR response elements (summary by Korf et al., 2009 [PubMed 19436111]).[supplied by OMIM, Jan 2010]

PEST containing nuclear protein pseudogene 2

nuclear VCP-like

This gene encodes a member of the AAA (ATPases associated with diverse cellular activities) superfamily. Multiple transcript variants encoding different isoforms have been found for this gene. Two encoded proteins, described as major and minor isoforms, have been localized to distinct regions of the nucleus. The largest encoded protein (major isoform) has been localized to the nucleolus and shown to participate in ribosome biosynthesis (PMID: 15469983, 16782053), while the minor isoform has been localized to the nucleoplasmin. [provided by RefSeq, Aug 2011]

small nuclear ribonucleoprotein polypeptide E pseudogene 10

CTD nuclear envelope phosphatase 1 pseudogene

nuclear-encoded mitochondrial transfer RNA-Gln (TTG) 1-1

nuclear-encoded mitochondrial transfer RNA-Gln (TTG) 15-1

RNA, U7 small nuclear 46 pseudogene

nuclear receptor subfamily 3, group C, member 2

This gene encodes the mineralocorticoid receptor, which mediates aldosterone actions on salt and water balance within restricted target cells. The protein functions as a ligand-dependent transcription factor that binds to mineralocorticoid response elements in order to transactivate target genes. Mutations in this gene cause autosomal dominant pseudohypoaldosteronism type I, a disorder characterized by urinary salt wasting. Defects in this gene are also associated with early onset hypertension with severe exacerbation in pregnancy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)

This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175). [provided by RefSeq, Feb 2011]

RNA, U5A small nuclear 1

nuclear factor, erythroid 2-like 3

This gene encodes a member of the cap 'n' collar basic-region leucine zipper family of transcription factors. The encoded protein heterodimerizes with small musculoaponeurotic fibrosarcoma factors to bind antioxidant response elements in target genes. This protein is a membrane bound glycoprotein that is targeted to the endoplasmic reticulum and the nuclear envelope. Pseudogenes of this gene are found on chromosomes 16, 17, and 18. [provided by RefSeq, Mar 2009]

nuclear factor, erythroid 2-like 2

This gene encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. The encoded transcription factor regulates genes which contain antioxidant response elements (ARE) in their promoters; many of these genes encode proteins involved in response to injury and inflammation which includes the production of free radicals. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

nuclear factor, erythroid 2-like 1

This gene encodes a protein that is involved in globin gene expression in erythrocytes. Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene, NFE2L1, and for "nuclear respiratory factor 1" which has an official symbol of NRF1. [provided by RefSeq, Jul 2008]

RNA, U6 small nuclear 35, pseudogene

small nuclear ribonucleoprotein D2 pseudogene 2

small nuclear ribonucleoprotein D2 pseudogene 1

nuclear receptor subfamily 1, group H, member 3

The protein encoded by this gene belongs to the NR1 subfamily of the nuclear receptor superfamily. The NR1 family members are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. This protein is highly expressed in visceral organs, including liver, kidney and intestine. It forms a heterodimer with retinoid X receptor (RXR), and regulates expression of target genes containing retinoid response elements. Studies in mice lacking this gene suggest that it may play an important role in the regulation of cholesterol homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

nuclear pore complex-interacting protein family member B5-like

RNA, U7 small nuclear 40 pseudogene

RNA, U7 small nuclear 69 pseudogene

RNA, U7 small nuclear 34 pseudogene

heterogeneous nuclear ribonucleoprotein A3 pseudogene 7

heterogeneous nuclear ribonucleoprotein A3 pseudogene 3

RNA, U5B small nuclear 4, pseudogene

heterogeneous nuclear ribonucleoprotein A3 pseudogene 9

heterogeneous nuclear ribonucleoprotein A3 pseudogene 8

RNA, U7 small nuclear 55 pseudogene

nuclear cap binding protein subunit 2-like

RNA, U5A small nuclear 3, pseudogene

hepatocyte nuclear factor 4, gamma

hepatocyte nuclear factor 4, alpha

The protein encoded by this gene is a nuclear transcription factor which binds DNA as a homodimer. The encoded protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. This gene may play a role in development of the liver, kidney, and intestines. Mutations in this gene have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I. Alternative splicing of this gene results in multiple transcript variants encoding several different isoforms. [provided by RefSeq, Apr 2012]

required for meiotic nuclear division 1 homolog (S. cerevisiae) pseudogene

RNA, U7 small nuclear 26 pseudogene

small nuclear ribonucleoprotein polypeptide N

The protein encoded by this gene is one polypeptide of a small nuclear ribonucleoprotein complex and belongs to the snRNP SMB/SMN family. The protein plays a role in pre-mRNA processing, possibly tissue-specific alternative splicing events. Although individual snRNPs are believed to recognize specific nucleic acid sequences through RNA-RNA base pairing, the specific role of this family member is unknown. The protein arises from a bicistronic transcript that also encodes a protein identified as the SNRPN upstream reading frame (SNURF). Multiple transcription initiation sites have been identified and extensive alternative splicing occurs in the 5' untranslated region. Additional splice variants have been described but sequences for the complete transcripts have not been determined. The 5' UTR of this gene has been identified as an imprinting center. Alternative splicing or deletion caused by a translocation event in this paternally-expressed region is responsible for Angelman syndrome or Prader-Willi syndrome due to parental imprint switch failure. [provided by RefSeq, Jul 2008]

small nuclear ribonucleoprotein polypeptides B and B1

The protein encoded by this gene is one of several nuclear proteins that are found in common among U1, U2, U4/U6, and U5 small ribonucleoprotein particles (snRNPs). These snRNPs are involved in pre-mRNA splicing, and the encoded protein may also play a role in pre-mRNA splicing or snRNP structure. Autoantibodies from patients with systemic lupus erythematosus frequently recognize epitopes on the encoded protein. Two transcript variants encoding different isoforms (B and B') have been found for this gene. [provided by RefSeq, Jul 2008]

small nuclear ribonucleoprotein polypeptide C

This gene encodes one of the specific protein components of the U1 small nuclear ribonucleoprotein (snRNP) particle required for the formation of the spliceosome. The encoded protein participates in the processing of nuclear precursor messenger RNA splicing. snRNP particles are attacked by autoantibodies frequently produced by patients with connective tissue diseases. The genome contains several pseudogenes of this functional gene. Alternative splicing results in a non-coding transcript variant.[provided by RefSeq, Oct 2009]

small nuclear ribonucleoprotein polypeptide A

The protein encoded by this gene associates with stem loop II of the U1 small nuclear ribonucleoprotein, which binds the 5' splice site of precursor mRNAs and is required for splicing. The encoded protein autoregulates itself by polyadenylation inhibition of its own pre-mRNA via dimerization and has been implicated in the coupling of splicing and polyadenylation. [provided by RefSeq, Oct 2010]

small nuclear ribonucleoprotein polypeptide F

small nuclear ribonucleoprotein polypeptide G

small nuclear ribonucleoprotein polypeptide E

nuclear-encoded mitochondrial transfer RNA-Gln (TTG) 14-1

nuclear factor, interleukin 3 regulated

The protein encoded by this gene is a transcriptional regulator that binds as a homodimer to activating transcription factor (ATF) sites in many cellular and viral promoters. The encoded protein represses PER1 and PER2 expression and therefore plays a role in the regulation of circadian rhythm. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Feb 2014]

RNA, variant U1 small nuclear 8

RNA, variant U1 small nuclear 4

RNA, variant U1 small nuclear 6

RNA, variant U1 small nuclear 7

RNA, variant U1 small nuclear 1

U2 small nuclear RNA auxiliary factor 1

This gene belongs to the splicing factor SR family of genes. U2 auxiliary factor, comprising a large and a small subunit, is a non-snRNP protein required for the binding of U2 snRNP to the pre-mRNA branch site. This gene encodes the small subunit which plays a critical role in both constitutive and enhancer-dependent RNA splicing by directly mediating interactions between the large subunit and proteins bound to the enhancers. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

U2 small nuclear RNA auxiliary factor 2

U2 auxiliary factor (U2AF), comprised of a large and a small subunit, is a non-snRNP protein required for the binding of U2 snRNP to the pre-mRNA branch site. This gene encodes the U2AF large subunit which contains a sequence-specific RNA-binding region with 3 RNA recognition motifs and an Arg/Ser-rich domain necessary for splicing. The large subunit binds to the polypyrimidine tract of introns early during spliceosome assembly. Multiple transcript variants have been detected for this gene, but the full-length natures of only two have been determined to date. [provided by RefSeq, Jul 2008]

nuclear prelamin A recognition factor

Several proteins have been found to be prenylated and methylated at their carboxyl-terminal ends. Prenylation was initially believed to be important only for membrane attachment. However, another role for prenylation appears to be its importance in protein-protein interactions. The only nuclear proteins known to be prenylated in mammalian cells are prelamin A- and B-type lamins. Prelamin A is farnesylated and carboxymethylated on the cysteine residue of a carboxyl-terminal CaaX motif. This post-translationally modified cysteine residue is removed from prelamin A when it is endoproteolytically processed into mature lamin A. The protein encoded by this gene binds to the prenylated prelamin A carboxyl-terminal tail domain. It may be a component of a prelamin A endoprotease complex. The encoded protein is located in the nucleus, where it partially colocalizes with the nuclear lamina. It shares limited sequence similarity with iron-only bacterial hydrogenases. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene, including one with a novel exon that is generated by RNA editing. [provided by RefSeq, Jul 2008]

heterogeneous nuclear ribonucleoprotein A3 pseudogene 4

heterogeneous nuclear ribonucleoprotein A3 pseudogene 2

heterogeneous nuclear ribonucleoprotein A3 pseudogene 1

This locus shares sequence similarity with heterogeneous nuclear ribonuclear proteins and represents an apparent transcribed pseudogene of the HNRPA3 gene, which maps to chromosome 2. [provided by RefSeq, Jul 2008]

RNA, U6 small nuclear 75, pseudogene

RNA, U5E small nuclear 4, pseudogene

TERF1 (TRF1)-interacting nuclear factor 2

This gene encodes one of the proteins of the shelterin, or telosome, complex which protects telomeres by allowing the cell to distinguish between telomeres and regions of DNA damage. The protein encoded by this gene is a critical part of shelterin; it interacts with the three DNA-binding proteins of the shelterin complex, and it is important for assembly of the complex. Mutations in this gene cause dyskeratosis congenita (DKC), an inherited bone marrow failure syndrome. [provided by RefSeq, Mar 2010]

small nuclear ribonucleoprotein polypeptide C pseudogene 19

small nuclear ribonucleoprotein polypeptide C pseudogene 18

small nuclear ribonucleoprotein polypeptide C pseudogene 15

small nuclear ribonucleoprotein polypeptide C pseudogene 14

small nuclear ribonucleoprotein polypeptide C pseudogene 12

small nuclear ribonucleoprotein polypeptide C pseudogene 11

nuclear respiratory factor 1

This gene encodes a protein that homodimerizes and functions as a transcription factor which activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. The protein has also been associated with the regulation of neurite outgrowth. Alternative splicing results in multiple transcript variants. Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene and for "nuclear factor (erythroid-derived 2)-like 1" which has an official symbol of NFE2L1. [provided by RefSeq, May 2014]

nuclear transcription factor Y, alpha pseudogene 1

RNA, U1 small nuclear 11, pseudogene

RNA, U7 small nuclear 7 pseudogene

RNA, U6 small nuclear 81, pseudogene

heterogeneous nuclear ribonucleoprotein R pseudogene 1

heterogeneous nuclear ribonucleoprotein R pseudogene 2

heterogeneous nuclear ribonucleoprotein R pseudogene 3

RNA, U7 small nuclear 76 pseudogene

RNA, U4 small nuclear 2

nuclear pore associated protein 1 pseudogene

proliferating cell nuclear antigen pseudogene 3

small nuclear ribonucleoprotein polypeptide F pseudogene 4

small nuclear ribonucleoprotein polypeptide F pseudogene 2

small nuclear ribonucleoprotein polypeptide F pseudogene 1

SP140 nuclear body protein

nuclear receptor subfamily 1, group I, member 3

This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

nuclear receptor subfamily 1, group I, member 2

This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG (CUG) translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized. [provided by RefSeq, Jul 2008]

nuclear pore complex interacting protein family, member B9

Smad nuclear interacting protein 1

This gene encodes a protein that contains a coiled-coil motif and C-terminal forkhead-associated (FHA) domain. The encoded protein functions as a transcriptional coactivator that increases c-Myc activity and inhibits transforming growth factor beta (TGF-beta) and nuclear factor kappa-B (NF-kB) signaling. The encoded protein also regulates the stability of cyclin D1 mRNA, and may play a role in cell proliferation and cancer progression. Mutations in this gene are a cause of psychomotor retardation, epilepsy, and craniofacial dysmorphism (PMRED). [provided by RefSeq, Mar 2012]

RNA, U4 small nuclear 5, pseudogene

small nuclear ribonucleoprotein polypeptide G pseudogene 3

small nuclear ribonucleoprotein Sm D1 pseudogene

RNA, U4 small nuclear 10, pseudogene

U5 small nuclear ribonucleoprotein 200 kDa helicase pseudogene

heterogeneous nuclear ribonucleoprotein A1 pseudogene 74

RNA, U1 small nuclear 19, pseudogene

RNA, U6 small nuclear 14, pseudogene

RNA, U5F small nuclear 8, pseudogene

RNA, U7 small nuclear 45 pseudogene

RNA, U7 small nuclear 84 pseudogene

aryl hydrocarbon receptor nuclear translocator

This gene encodes a protein containing a basic helix-loop-helix domain and two characteristic PAS domains along with a PAC domain. The encoded protein binds to ligand-bound aryl hydrocarbon receptor and aids in the movement of this complex to the nucleus, where it promotes the expression of genes involved in xenobiotic metabolism. This protein is also a co-factor for transcriptional regulation by hypoxia-inducible factor 1. Chromosomal translocation of this locus with the ETV6 (ets variant 6) gene on chromosome 12 have been described in leukemias. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2013]

Sjogren syndrome nuclear autoantigen 1

RNA, U6 small nuclear 30, pseudogene

heterogeneous nuclear ribonucleoprotein A2/B1

This gene belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. This gene has been described to generate two alternatively spliced transcript variants which encode different isoforms. [provided by RefSeq, Jul 2008]

RNA, U6 small nuclear 78, pseudogene

RNA, U7 small nuclear 39 pseudogene

RNA, U7 small nuclear 64 pseudogene

nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) pseudogene

heterogeneous nuclear ribonucleoprotein A1 pseudogene 20

heterogeneous nuclear ribonucleoprotein A1 pseudogene 21

heterogeneous nuclear ribonucleoprotein A1 pseudogene 22

heterogeneous nuclear ribonucleoprotein A1 pseudogene 23

heterogeneous nuclear ribonucleoprotein A1 pseudogene 24

heterogeneous nuclear ribonucleoprotein A1 pseudogene 25

heterogeneous nuclear ribonucleoprotein A1 pseudogene 26

heterogeneous nuclear ribonucleoprotein A1 pseudogene 27

heterogeneous nuclear ribonucleoprotein A1 pseudogene 28

RNA, U7 small nuclear 70 pseudogene

nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3

The product of this gene is a member of the nuclear factors of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation and an inducible nuclear component. Other members of this family participate to form this complex also. The product of this gene plays a role in the regulation of gene expression in T cells and immature thymocytes. Several transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Nov 2010]

heterogeneous nuclear ribonucleoprotein K pseudogene 5

heterogeneous nuclear ribonucleoprotein K pseudogene 4

heterogeneous nuclear ribonucleoprotein K pseudogene 1

heterogeneous nuclear ribonucleoprotein K pseudogene 3

heterogeneous nuclear ribonucleoprotein K pseudogene 2

RNA, U7 small nuclear 56 pseudogene

nuclear receptor subfamily 0, group B, member 2

The protein encoded by this gene is an unusual orphan receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain. The gene product is a member of the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones, a subset of which do not have known ligands and are referred to as orphan nuclear receptors. The protein has been shown to interact with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation. In addition, interaction with estrogen receptors has been demonstrated, leading to inhibition of function. Studies suggest that the protein represses nuclear hormone receptor-mediated transactivation via two separate steps: competition with coactivators and the direct effects of its transcriptional repressor function. [provided by RefSeq, Jul 2008]

nuclear receptor subfamily 0, group B, member 1

This gene encodes a protein that contains a DNA-binding domain. The encoded protein acts as a dominant-negative regulator of transcription which is mediated by the retinoic acid receptor. This protein also functions as an anti-testis gene by acting antagonistically to Sry. Mutations in this gene result in both X-linked congenital adrenal hypoplasia and hypogonadotropic hypogonadism. [provided by RefSeq, Jul 2008]

RNA, U5F small nuclear 1

C1D nuclear receptor corepressor pseudogene 1

C1D nuclear receptor corepressor pseudogene 3

nuclear pore complex interacting protein family, member B11

nuclear pore complex interacting protein family, member B1, pseudogene

required for meiotic nuclear division 5 homolog A (S. cerevisiae)

required for meiotic nuclear division 5 homolog B (S. cerevisiae)

RNA, U7 small nuclear 15 pseudogene

nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha

This gene encodes a member of the NF-kappa-B inhibitor family, which contain multiple ankrin repeat domains. The encoded protein interacts with REL dimers to inhibit NF-kappa-B/REL complexes which are involved in inflammatory responses. The encoded protein moves between the cytoplasm and the nucleus via a nuclear localization signal and CRM1-mediated nuclear export. Mutations in this gene have been found in ectodermal dysplasia anhidrotic with T-cell immunodeficiency autosomal dominant disease. [provided by RefSeq, Aug 2011]

RNA, U1 small nuclear 1

RNA, U1 small nuclear 4

RNA, U6 small nuclear 59, pseudogene

RNA, U7 small nuclear 31 pseudogene

small nuclear ribonucleoprotein-associated protein N-like

target of EGR1, member 1 (nuclear)

RNA, U5B small nuclear 2, pseudogene

RNA, U5E small nuclear 3, pseudogene

RNA, U7 small nuclear 50 pseudogene

nuclear pore complex interacting protein family, member B3

nuclear pore complex interacting protein family, member B4

nuclear pore complex interacting protein family, member B7

nuclear pore complex interacting protein family, member B6

nuclear pore complex interacting protein family, member B8

RNA, U5A small nuclear 6, pseudogene

large 60S subunit nuclear export GTPase 1

This gene encodes a protein related to the yeast large subunit GTPase 1. The encoded protein is necessary for cell viability and may localize in the endoplasmic reticulum, nucleus and cytoplasm.[provided by RefSeq, Feb 2009]

heterogeneous nuclear ribonucleoprotein L-like

HNRNPLL is a master regulator of activation-induced alternative splicing in T cells. In particular, it alters splicing of CD45 (PTPRC; MIM 151460), a tyrosine phosphatase essential for T-cell development and activation (Oberdoerffer et al., 2008 [PubMed 18669861]).[supplied by OMIM, Aug 2008]

RNA, U5E small nuclear 10, pseudogene

RNA, U7 small nuclear 29 pseudogene

small nuclear ribonucleoprotein polypeptides B and B1 pseudogene 1

nuclear factor, erythroid 2-like 3 pseudogene 2

heterogeneous nuclear ribonucleoprotein A1 pseudogene 40

RNA, U7 small nuclear 79 pseudogene

RNA, U6 small nuclear 28, pseudogene

gem (nuclear organelle) associated protein 2 pseudogene 2

gem (nuclear organelle) associated protein 2 pseudogene 1

nuclear pore complex-interacting protein family member B5-like

small nuclear ribonucleoprotein polypeptide F pseudogene 3

RNA, U2 small nuclear 5, pseudogene

RAD9-HUS1-RAD1 interacting nuclear orphan 1

RNA, U5F small nuclear 3, pseudogene

nuclear autoantigenic sperm protein pseudogene 1

LSM10, U7 small nuclear RNA associated

LSM11, U7 small nuclear RNA associated

RNA, U7 small nuclear 48 pseudogene

heterogeneous nuclear ribonucleoprotein C-like 1

heterogeneous nuclear ribonucleoprotein C-like 3

heterogeneous nuclear ribonucleoprotein C-like 2

heterogeneous nuclear ribonucleoprotein C-like 4

RNA, U6 small nuclear 42, pseudogene

nuclear transcription factor Y, gamma pseudogene

acidic (leucine-rich) nuclear phosphoprotein 32 family, member B pseudogene 3

heterogeneous nuclear ribonucleoprotein U pseudogene 1

heterogeneous nuclear ribonucleoprotein D-like

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two RRM domains that bind to RNAs. Three alternatively spliced transcript variants have been described for this gene. One of the variants is probably not translated because the transcript is a candidate for nonsense-mediated mRNA decay. The protein isoforms encoded by this gene are similar to its family member HNRPD. [provided by RefSeq, May 2011]

nuclear-encoded mitochondrial transfer RNA-Gln (CTG) 1-1

nuclear transport factor 2

The protein encoded by this gene is a cytosolic factor that facilitates protein transport into the nucleus. It interacts with the nuclear pore complex glycoprotein p62. This encoded protein acts at a relative late stage of nuclear protein import, subsequent to the initial docking of nuclear import ligand at the nuclear envelope. It is thought to be part of a multicomponent system of cytosolic factors that assemble at the pore complex during nuclear import. [provided by RefSeq, Jul 2008]

RNA, U7 small nuclear 21 pseudogene

heterogeneous nuclear ribonucleoprotein D-like pseudogene 2

heterogeneous nuclear ribonucleoprotein D-like pseudogene 1

heterogeneous nuclear ribonucleoprotein A1 pseudogene 32

heterogeneous nuclear ribonucleoprotein A1 pseudogene 31

heterogeneous nuclear ribonucleoprotein A1 pseudogene 30

nuclear receptor coactivator 4 pseudogene

nuclear distribution gene C homolog (A. nidulans) pseudogene 2

nuclear distribution gene C homolog (A. nidulans) pseudogene 1

small nuclear ribonucleoprotein 35kDa (U11/U12)

The protein encoded by this gene is a homolog of the U1-snRNP binding protein. The N-terminal half contains a RNA recognition motif and the C-terminal half is rich in Arg/Asp and Arg/Glu dipeptides, which is a characteristic of a variety of splicing factors. This protein is a component of the U11/U12 small nuclear ribonucleoproteins (snRNP) that form part of the U12-type spliceosome. Alternative splicing results in multiple transcript variants encoding two distinct isoforms and representing a non-protein coding variant. [provided by RefSeq, Aug 2013]

nuclear receptor subfamily 1, group I, member 4

RNA, U7 small nuclear 3 pseudogene

RNA, U7 small nuclear 2 pseudogene

RNA, U2 small nuclear 7, pseudogene

musculoskeletal, embryonic nuclear protein 1

RNA, U6 small nuclear 33, pseudogene

LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae)

Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM, Apr 2004]

SP110 nuclear body protein

The nuclear body is a multiprotein complex that may have a role in the regulation of gene transcription. This gene is a member of the SP100/SP140 family of nuclear body proteins and encodes a leukocyte-specific nuclear body component. The protein can function as an activator of gene transcription and may serve as a nuclear hormone receptor coactivator. In addition, it has been suggested that the protein may play a role in ribosome biogenesis and in the induction of myeloid cell differentiation. Alternative splicing has been observed for this gene and three transcript variants, encoding distinct isoforms, have been identified. [provided by RefSeq, Jul 2008]

RNA, U7 small nuclear 67 pseudogene

heterogeneous nuclear ribonucleoprotein A1, A2/B1 homolog

heterogeneous nuclear ribonucleoprotein A1 pseudogene 73

heterogeneous nuclear ribonucleoprotein A1 pseudogene 71

heterogeneous nuclear ribonucleoprotein A1 pseudogene 70

nuclear pore complex interacting protein pseudogene

heterogeneous nuclear ribonucleoprotein A1-like

nuclear-encoded mitochondrial transfer RNA-Gln (TTG) 4-1

CTD nuclear envelope phosphatase 1 regulatory subunit 1

This gene encodes a transmembrane protein that belongs to the Tmemb_18A family. A similar protein in yeast is a component of an endoplasmic reticulum-associated protein phosphatase complex and is thought to play a role in the synthesis of triacylglycerol. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

nuclear-encoded mitochondrial transfer RNA-Gln (TTG) 5-1

BTG3 associated nuclear protein

This gene encodes a protein that binds to matrix attachment regions. The protein forms a complex with p53 and negatively regulates p53 transcription, and functions as a tumor suppressor and cell cycle regulator. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]

nuclear distribution protein nudE-like 1-like

RNA, U7 small nuclear 83 pseudogene

RNA, U7 small nuclear 16 pseudogene

nuclear factor I/B

nuclear pore complex-interacting protein family member A5-like

nuclear pore complex-interacting protein family member B9-like

nuclear factor I/C (CCAAT-binding transcription factor)

The protein encoded by this gene belongs to the CTF/NF-I family. These are dimeric DNA-binding proteins, and function as cellular transcription factors and as replication factors for adenovirus DNA replication. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]

nuclear factor I/A

This gene encodes a member of the NF1 (nuclear factor 1) family of transcription factors. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

nuclear factor I/X (CCAAT-binding transcription factor)

The protein encoded by this gene is a transcription factor that binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3 in viral and cellular promoters. The encoded protein can also stimulate adenovirus replication in vitro. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2012]

From GO Biological Process Annotations

genes participating in the nuclear-transcribed mrna catabolic process, nonsense-mediated decay biological process from the curated GO Biological Process Annotations dataset.

From GO Biological Process Annotations

genes participating in the nuclear polyadenylation-dependent mrna catabolic process biological process from the curated GO Biological Process Annotations dataset.

From CORUM Protein Complexes

proteins in the mRNA decay complex (UPF1, UPF2, UPF3B, DCP2, XRN1, XRN2, EXOSC2, EXOSC4, EXOSC10, PARN) protein complex from the CORUM Protein Complexes dataset.

From Reactome Pathways

proteins participating in the Deadenylation-dependent mRNA decay pathway from the Reactome Pathways dataset.

From Reactome Pathways

proteins participating in the mRNA decay by 3' to 5' exoribonuclease pathway from the Reactome Pathways dataset.

From Reactome Pathways

proteins participating in the mRNA decay by 5' to 3' exoribonuclease pathway from the Reactome Pathways dataset.

From GO Biological Process Annotations

genes participating in the polyadenylation-dependent mrna catabolic process biological process from the curated GO Biological Process Annotations dataset.

From GO Biological Process Annotations

genes participating in the mrna catabolic process biological process from the curated GO Biological Process Annotations dataset.

From GO Biological Process Annotations

genes participating in the mitochondrial mrna catabolic process biological process from the curated GO Biological Process Annotations dataset.

From GO Biological Process Annotations

genes participating in the pre-mrna catabolic process biological process from the curated GO Biological Process Annotations dataset.

From GO Biological Process Annotations

genes participating in the polyuridylation-dependent mrna catabolic process biological process from the curated GO Biological Process Annotations dataset.

From GO Biological Process Annotations

genes participating in the positive regulation of mrna catabolic process biological process from the curated GO Biological Process Annotations dataset.

From GO Biological Process Annotations

genes participating in the negative regulation of mrna catabolic process biological process from the curated GO Biological Process Annotations dataset.

From GO Biological Process Annotations

genes participating in the histone mrna catabolic process biological process from the curated GO Biological Process Annotations dataset.

From GO Biological Process Annotations

genes participating in the regulation of mrna catabolic process biological process from the curated GO Biological Process Annotations dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term nonsense in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From GO Biological Process Annotations

genes participating in the nuclear polyadenylation-dependent rrna catabolic process biological process from the curated GO Biological Process Annotations dataset.

From GO Biological Process Annotations

genes participating in the nuclear polyadenylation-dependent ncrna catabolic process biological process from the curated GO Biological Process Annotations dataset.

From GO Biological Process Annotations

genes participating in the nuclear polyadenylation-dependent trna catabolic process biological process from the curated GO Biological Process Annotations dataset.

From GO Biological Process Annotations

genes participating in the nuclear retention of unspliced pre-mrna at the site of transcription biological process from the curated GO Biological Process Annotations dataset.

From GO Biological Process Annotations

genes participating in the nuclear mrna surveillance biological process from the curated GO Biological Process Annotations dataset.

From GO Biological Process Annotations

genes participating in the nuclear retention of pre-mrna with aberrant 3'-ends at the site of transcription biological process from the curated GO Biological Process Annotations dataset.

From GO Biological Process Annotations

genes participating in the nuclear retention of pre-mrna at the site of transcription biological process from the curated GO Biological Process Annotations dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term decaypromoting in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term decay in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term decayaccelerating in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From MPO Gene-Phenotype Associations

gene mutations causing the short excitatory postsynaptic current decay time phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

From COMPARTMENTS Curated Protein Localization Evidence Scores

proteins localized to the nuclear pore nuclear basket cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.

From GO Biological Process Annotations

genes participating in the nuclear fragmentation involved in apoptotic nuclear change biological process from the curated GO Biological Process Annotations dataset.

From GO Biological Process Annotations

genes participating in the nuclear matrix anchoring at nuclear membrane biological process from the curated GO Biological Process Annotations dataset.

From GO Cellular Component Annotations

proteins localized to the nuclear pore nuclear basket cellular component from the curated GO Cellular Component Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the U1 small nuclear ribonucleoprotein A/U2 small nuclear ribonucleoprotein B'' protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Heterogeneous nuclear ribonucleoprotein M, PY nuclear localisation signal protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From GO Biological Process Annotations

genes participating in the histone mrna metabolic process biological process from the curated GO Biological Process Annotations dataset.

From GO Biological Process Annotations

genes participating in the mrna metabolic process biological process from the curated GO Biological Process Annotations dataset.

From GO Biological Process Annotations

genes participating in the positive regulation of mrna metabolic process biological process from the curated GO Biological Process Annotations dataset.

From GO Biological Process Annotations

genes participating in the negative regulation of mrna metabolic process biological process from the curated GO Biological Process Annotations dataset.

From GO Biological Process Annotations

genes participating in the regulation of mrna metabolic process biological process from the curated GO Biological Process Annotations dataset.

From GO Biological Process Annotations

genes participating in the pyrimidine deoxyribonucleoside catabolic process biological process from the curated GO Biological Process Annotations dataset.

From GO Biological Process Annotations

genes participating in the anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process biological process from the curated GO Biological Process Annotations dataset.

From GO Biological Process Annotations

genes participating in the ganglioside catabolic process biological process from the curated GO Biological Process Annotations dataset.

From GO Biological Process Annotations

genes participating in the regulation of proteasomal ubiquitin-dependent protein catabolic process biological process from the curated GO Biological Process Annotations dataset.

From GO Biological Process Annotations

genes participating in the deoxyribonucleoside triphosphate catabolic process biological process from the curated GO Biological Process Annotations dataset.

From GO Biological Process Annotations

genes participating in the scf-dependent proteasomal ubiquitin-dependent protein catabolic process biological process from the curated GO Biological Process Annotations dataset.

From GO Biological Process Annotations

genes participating in the positive regulation of hydrogen peroxide catabolic process biological process from the curated GO Biological Process Annotations dataset.