Name

NUP98 Gene

nucleoporin 98kDa

Signal-mediated nuclear import and export proceed through the nuclear pore complex (NPC), which is comprised of approximately 50 unique proteins collectively known as nucleoporins. The 98 kDa nucleoporin is generated through a biogenesis pathway that involves synthesis and proteolytic cleavage of a 186 kDa precursor protein. This cleavage results in the 98 kDa nucleoporin as well as a 96 kDa nucleoporin, both of which are localized to the nucleoplasmic side of the NPC. Rat studies show that the 98 kDa nucleoporin functions as one of several docking site nucleoporins of transport substrates. The human gene has been shown to fuse to several genes following chromosome translocations in acute myelogenous leukemia (AML) and T-cell acute lymphocytic leukemia (T-ALL). This gene is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. [provided by RefSeq, May 2010]

nup98 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term nup98 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

NUP98 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for NUP98 from the Pathway Commons Protein-Protein Interactions dataset.

NPC subcomplex (NUP98, NUP107, NUP133, NUP160) Gene Set

From CORUM Protein Complexes

proteins in the NPC subcomplex (NUP98, NUP107, NUP133, NUP160) protein complex from the CORUM Protein Complexes dataset.

nup98hox Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term nup98hox in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

nup98hoxa10 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term nup98hoxa10 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

nup98related Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term nup98related in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

nup98hoxd13 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term nup98hoxd13 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

nup98ccdc28a Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term nup98ccdc28a in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

nup98nsd1 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term nup98nsd1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

nup98hoxc13 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term nup98hoxc13 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

nup98mll Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term nup98mll in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

nup98hoxa9 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term nup98hoxa9 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Leukemia NUP98 fusion partner 1 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Leukemia NUP98 fusion partner 1 protein domain from the InterPro Predicted Protein Domain Annotations dataset.