Name

ABAT Gene

4-aminobutyrate aminotransferase

4-aminobutyrate aminotransferase (ABAT) is responsible for catabolism of gamma-aminobutyric acid (GABA), an important, mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde. The active enzyme is a homodimer of 50-kD subunits complexed to pyridoxal-5-phosphate. The protein sequence is over 95% similar to the pig protein. GABA is estimated to be present in nearly one-third of human synapses. ABAT in liver and brain is controlled by 2 codominant alleles with a frequency in a Caucasian population of 0.56 and 0.44. The ABAT deficiency phenotype includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. [provided by RefSeq, Jul 2008]

abat Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term abat in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

ABAT Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for ABAT from the Pathway Commons Protein-Protein Interactions dataset.

Abatacept Gene Set

From DrugBank Drug Targets

interacting proteins for the Abatacept drug from the curated DrugBank Drug Targets dataset.

abatacept Gene Set

From Guide to Pharmacology Chemical Ligands of Receptors

receptors of the abatacept ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset.