Name

ABCC8 Gene

ATP-binding cassette, sub-family C (CFTR/MRP), member 8

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a modulator of ATP-sensitive potassium channels and insulin release. Mutations and deficiencies in this protein have been observed in patients with hyperinsulinemic hypoglycemia of infancy, an autosomal recessive disorder of unregulated and high insulin secretion. Mutations have also been associated with non-insulin-dependent diabetes mellitus type II, an autosomal dominant disease of defective insulin secretion. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2013]

abcc8 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term abcc8 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

ABCC8 Gene Set

From Hub Proteins Protein-Protein Interactions

interacting proteins for hub protein ABCC8 from the curated Hub Proteins Protein-Protein Interactions dataset.

ABCC8 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for ABCC8 from the Pathway Commons Protein-Protein Interactions dataset.

abcc8kcnj11 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term abcc8kcnj11 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.