Name

ACLY Gene

ATP citrate lyase

ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Dec 2014]

acly Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term acly in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

ACLY Gene Set

From NURSA Protein-Protein Interactions

interacting proteins for ACLY from the NURSA Protein-Protein Interactions dataset.

ACLY Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for ACLY from the Pathway Commons Protein-Protein Interactions dataset.