Name

ADD3 Gene

adducin 3 (gamma)

Adducins are heteromeric proteins composed of different subunits referred to as adducin alpha, beta and gamma. The three subunits are encoded by distinct genes and belong to a family of membrane skeletal proteins involved in the assembly of spectrin-actin network in erythrocytes and at sites of cell-cell contact in epithelial tissues. While adducins alpha and gamma are ubiquitously expressed, the expression of adducin beta is restricted to brain and hematopoietic tissues. Adducin, originally purified from human erythrocytes, was found to be a heterodimer of adducins alpha and beta. Polymorphisms resulting in amino acid substitutions in these two subunits have been associated with the regulation of blood pressure in an animal model of hypertension. Heterodimers consisting of alpha and gamma subunits have also been described. Structurally, each subunit is comprised of two distinct domains. The amino-terminal region is protease resistant and globular in shape, while the carboxy-terminal region is protease sensitive. The latter contains multiple phosphorylation sites for protein kinase C, the binding site for calmodulin, and is required for association with spectrin and actin. Alternatively spliced adducin gamma transcripts encoding different isoforms have been described. The functions of the different isoforms are not known. [provided by RefSeq, Jul 2008]

ADD3-AS1 Gene

ADD3 antisense RNA 1

add3 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term add3 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

ADD3 Gene Set

From NURSA Protein-Protein Interactions

interacting proteins for ADD3 from the NURSA Protein-Protein Interactions dataset.

ADD3 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for ADD3 from the Pathway Commons Protein-Protein Interactions dataset.