AIFM1 Gene

apoptosis-inducing factor, mitochondrion-associated, 1

This gene encodes a flavoprotein essential for nuclear disassembly in apoptotic cells, and it is found in the mitochondrial intermembrane space in healthy cells. Induction of apoptosis results in the translocation of this protein to the nucleus where it affects chromosome condensation and fragmentation. In addition, this gene product induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. Mutations in this gene cause combined oxidative phosphorylation deficiency 6, which results in a severe mitochondrial encephalomyopathy. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 10. [provided by RefSeq, May 2010]

AIFM1P1 Gene

apoptosis-inducing factor, mitochondrion-associated, 1 pseudogene 1

aifm1 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term aifm1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

AIFM1 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for AIFM1 from the Pathway Commons Protein-Protein Interactions dataset.