Name

ALOX5 Gene

arachidonate 5-lipoxygenase

This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

ALOX5AP Gene

arachidonate 5-lipoxygenase-activating protein

This gene encodes a protein which, with 5-lipoxygenase, is required for leukotriene synthesis. Leukotrienes are arachidonic acid metabolites which have been implicated in various types of inflammatory responses, including asthma, arthritis and psoriasis. This protein localizes to the plasma membrane. Inhibitors of its function impede translocation of 5-lipoxygenase from the cytoplasm to the cell membrane and inhibit 5-lipoxygenase activation. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2011]

alox5 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term alox5 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

ALOX5 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for ALOX5 from the Pathway Commons Protein-Protein Interactions dataset.

alox5apsg13s114aa Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term alox5apsg13s114aa in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

alox5ap Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term alox5ap in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

ALOX5AP Gene Set

From Guide to Pharmacology Protein Ligands of Receptors

receptors of the ALOX5AP ligand (protein) from the curated Guide to Pharmacology Protein Ligands of Receptors dataset.

ALOX5AP Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for ALOX5AP from the Pathway Commons Protein-Protein Interactions dataset.