Harmonizome

amyotrophic lateral sclerosis 2 (juvenile)

The protein encoded by this gene contains an ATS1/RCC1-like domain, a RhoGEF domain, and a vacuolar protein sorting 9 (VPS9) domain, all of which are guanine-nucleotide exchange factors that activate members of the Ras superfamily of GTPases. The protein functions as a guanine nucleotide exchange factor for the small GTPase RAB5. The protein localizes with RAB5 on early endosomal compartments, and functions as a modulator for endosomal dynamics. Mutations in this gene result in several forms of juvenile lateral sclerosis and infantile-onset ascending spastic paralysis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]

ALS2 C-terminal like

amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 11

amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 12

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term als2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for ALS2 from the Pathway Commons Protein-Protein Interactions dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term als2uxt in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term als2cr7 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term als2cl in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From NURSA Protein-Protein Interactions

interacting proteins for ALS2CR12 from the NURSA Protein-Protein Interactions dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for ALS2CL from the Pathway Commons Protein-Protein Interactions dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for ALS2CR11 from the Pathway Commons Protein-Protein Interactions dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for ALS2CR12 from the Pathway Commons Protein-Protein Interactions dataset.