Name

AMACR Gene

alpha-methylacyl-CoA racemase

This gene encodes a racemase. The encoded enzyme interconverts pristanoyl-CoA and C27-bile acylCoAs between their (R)- and (S)-stereoisomers. The conversion to the (S)-stereoisomers is necessary for degradation of these substrates by peroxisomal beta-oxidation. Encoded proteins from this locus localize to both mitochondria and peroxisomes. Mutations in this gene may be associated with adult-onset sensorimotor neuropathy, pigmentary retinopathy, and adrenomyeloneuropathy due to defects in bile acid synthesis. Alternatively spliced transcript variants have been described. Read-through transcription also exists between this gene and the upstream neighboring C1QTNF3 (C1q and tumor necrosis factor related protein 3) gene. [provided by RefSeq, Mar 2011]

C1QTNF3-AMACR Gene

C1QTNF3-AMACR readthrough (NMD candidate)

This locus represents naturally occurring read-through transcription between the neighboring C1q and tumor necrosis factor related protein 3 (C1QTNF3) and alpha-methylacyl-CoA racemase (AMACR) genes on chromosome 5. The read-through transcript is a candidate for nonsense-mediated mRNA decay (NMD), and is thus not likely to produce a protein product. [provided by RefSeq, Mar 2011]

amacr Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term amacr in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

AMACR Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for AMACR from the Pathway Commons Protein-Protein Interactions dataset.

amacrine Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term amacrine in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

amacrine cell differentiation Gene Set

From GO Biological Process Annotations

genes participating in the amacrine cell differentiation biological process from the curated GO Biological Process Annotations dataset.

decreased amacrine cell number Gene Set

From MPO Gene-Phenotype Associations

gene mutations causing the decreased amacrine cell number phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

absent amacrine cells Gene Set

From MPO Gene-Phenotype Associations

gene mutations causing the absent amacrine cells phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

amacrine cell degeneration Gene Set

From MPO Gene-Phenotype Associations

gene mutations causing the amacrine cell degeneration phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

abnormal amacrine cell number Gene Set

From MPO Gene-Phenotype Associations

gene mutations causing the abnormal amacrine cell number phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

abnormal amacrine cell morphology Gene Set

From MPO Gene-Phenotype Associations

gene mutations causing the abnormal amacrine cell morphology phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

increased amacrine cell number Gene Set

From MPO Gene-Phenotype Associations

gene mutations causing the increased amacrine cell number phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

amacrine cell Gene Set

From TISSUES Text-mining Tissue Protein Expression Evidence Scores

proteins co-occuring with the tissue amacrine cell in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset.