Name

ANK1 Gene

ankyrin 1, erythrocytic

Ankyrins are a family of proteins that link the integral membrane proteins to the underlying spectrin-actin cytoskeleton and play key roles in activities such as cell motility, activation, proliferation, contact and the maintenance of specialized membrane domains. Multiple isoforms of ankyrin with different affinities for various target proteins are expressed in a tissue-specific, developmentally regulated manner. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central region with a highly conserved spectrin binding domain; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. Ankyrin 1, the prototype of this family, was first discovered in the erythrocytes, but since has also been found in brain and muscles. Mutations in erythrocytic ankyrin 1 have been associated in approximately half of all patients with hereditary spherocytosis. Complex patterns of alternative splicing in the regulatory domain, giving rise to different isoforms of ankyrin 1 have been described. Truncated muscle-specific isoforms of ankyrin 1 resulting from usage of an alternate promoter have also been identified. [provided by RefSeq, Dec 2008]

ank1 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term ank1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

ANK1 Gene Set

From MSigDB Cancer Gene Co-expression Modules

co-expressed genes for ANK1 from the MSigDB Cancer Gene Co-expression Modules dataset.

ANK1 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for ANK1 from the Pathway Commons Protein-Protein Interactions dataset.

ank1e Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term ank1e in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.