Name

APLN Gene

apelin

This gene encodes a peptide that functions as an endogenous ligand for the G protein coupled receptor APJ. The encoded protein is synthesized as a prepropeptide that is processed into biologically active C-terminal fragments. The peptide fragments activate different tissue specific signaling pathways that regulate diverse biological functions including fluid homeostasis, cardiovascular function and insulin secretion. This protein also functions as a coreceptor for the human immunodeficiency virus 1.[provided by RefSeq, Feb 2010]

APLNR Gene

apelin receptor

This gene encodes a member of the G protein-coupled receptor gene family. The encoded protein is related to the angiotensin receptor, but is actually an apelin receptor that inhibits adenylate cyclase activity and plays a counter-regulatory role against the pressure action of angiotensin II by exerting hypertensive effect. It functions in the cardiovascular and central nervous systems, in glucose metabolism, in embryonic and tumor angiogenesis and as a human immunodeficiency virus (HIV-1) coreceptor. Two transcript variants resulting from alternative splicing have been identified. [provided by RefSeq, Jul 2009]

apln Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term apln in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

APLN Gene Set

From Guide to Pharmacology Protein Ligands of Receptors

receptors of the APLN ligand (protein) from the curated Guide to Pharmacology Protein Ligands of Receptors dataset.

APLN Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for APLN from the Pathway Commons Protein-Protein Interactions dataset.

aplnr Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term aplnr in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

APLN_KO_GDS3228_601_mouse_Heart Gene Set

From GEO Signatures of Differentially Expressed Genes for Gene Perturbations

genes differentially expressed following the APLN_KO_GDS3228_601_mouse_Heart gene perturbation from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.

APLNR Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for APLNR from the Pathway Commons Protein-Protein Interactions dataset.