Name

APLP2 Gene

amyloid beta (A4) precursor-like protein 2

This gene encodes amyloid precursor- like protein 2 (APLP2), which is a member of the APP (amyloid precursor protein) family including APP, APLP1 and APLP2. This protein is ubiquitously expressed. It contains heparin-, copper- and zinc- binding domains at the N-terminus, BPTI/Kunitz inhibitor and E2 domains in the middle region, and transmembrane and intracellular domains at the C-terminus. This protein interacts with major histocompatibility complex (MHC) class I molecules. The synergy of this protein and the APP is required to mediate neuromuscular transmission, spatial learning and synaptic plasticity. This protein has been implicated in the pathogenesis of Alzheimer's disease. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]

aplp2 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term aplp2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

APLP2 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for APLP2 from the Pathway Commons Protein-Protein Interactions dataset.

APLP2_KO_GDS4414_534_mouse_adult cortex Gene Set

From GEO Signatures of Differentially Expressed Genes for Gene Perturbations

genes differentially expressed following the APLP2_KO_GDS4414_534_mouse_adult cortex gene perturbation from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.

APLP2_KO_GDS4414_536_mouse_adult cortex Gene Set

From GEO Signatures of Differentially Expressed Genes for Gene Perturbations

genes differentially expressed following the APLP2_KO_GDS4414_536_mouse_adult cortex gene perturbation from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.

APLP2_KO_GDS4414_371_mouse_prefrontal cortex Gene Set

From GEO Signatures of Differentially Expressed Genes for Gene Perturbations

genes differentially expressed following the APLP2_KO_GDS4414_371_mouse_prefrontal cortex gene perturbation from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.