Name

ARNT2 Gene

aryl-hydrocarbon receptor nuclear translocator 2

This gene encodes a member of the basic-helix-loop-helix-Per-Arnt-Sim (bHLH-PAS) superfamily of transcription factors. The encoded protein acts as a partner for several sensor proteins of the bHLH-PAS family, forming heterodimers with the sensor proteins that bind regulatory DNA sequences in genes responsive to developmental and environmental stimuli. Under hypoxic conditions, the encoded protein complexes with hypoxia-inducible factor 1alpha in the nucleus and this complex binds to hypoxia-responsive elements in enhancers and promoters of oxygen-responsive genes. A highly similar protein in mouse forms functional complexes with both aryl hydrocarbon receptors and Single-minded proteins, suggesting additional roles for the encoded protein in the metabolism of xenobiotic compounds and the regulation of neurogenesis, respectively. [provided by RefSeq, Dec 2013]

arnt2 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term arnt2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

ARNT2 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for ARNT2 from the Pathway Commons Protein-Protein Interactions dataset.

arnt2hif1alpha Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term arnt2hif1alpha in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

arnt2sim1 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term arnt2sim1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.