Name

ATP2B4 Gene

ATPase, Ca++ transporting, plasma membrane 4

The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 4. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

atp2b4 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term atp2b4 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

ATP2B4 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for ATP2B4 from the Pathway Commons Protein-Protein Interactions dataset.