Name

ATRX Gene

alpha thalassemia/mental retardation syndrome X-linked

The protein encoded by this gene contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Mutations in this gene are associated with an X-linked mental retardation (XLMR) syndrome most often accompanied by alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Aug 2013]

atrx Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term atrx in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

ATRX Gene Set

From MSigDB Cancer Gene Co-expression Modules

co-expressed genes for ATRX from the MSigDB Cancer Gene Co-expression Modules dataset.

ATRX Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for ATRX from the Pathway Commons Protein-Protein Interactions dataset.

ATRX-DAXX complex Gene Set

From CORUM Protein Complexes

proteins in the ATRX-DAXX complex protein complex from the CORUM Protein Complexes dataset.

atrxpa Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term atrxpa in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

atrxdaxx Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term atrxdaxx in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

BL4516 (ATRX) Gene Set

From NURSA Protein Complexes

proteins in the BL4516 (ATRX) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.