Name

BAG3 Gene

BCL2-associated athanogene 3

BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The protein encoded by this gene contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. [provided by RefSeq, Jul 2008]

bag3 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term bag3 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

BAG3 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for BAG3 from the Pathway Commons Protein-Protein Interactions dataset.

bag3mediated Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term bag3mediated in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

bag3hspb8 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term bag3hspb8 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.