Name

BIN1 Gene

bridging integrator 1

This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynamin, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in ten transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described. [provided by RefSeq, Sep 2011]

bin1 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term bin1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

BIN1 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for BIN1 from the Pathway Commons Protein-Protein Interactions dataset.

bin1ku Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term bin1ku in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

NB106A (BIN1) Gene Set

From NURSA Protein Complexes

proteins in the NB106A (BIN1) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.