Name

BMPR2 Gene

bone morphogenetic protein receptor, type II (serine/threonine kinase)

This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of two different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension, both familial and fenfluramine-associated, and with pulmonary venoocclusive disease. [provided by RefSeq, Jul 2008]

bmpr2 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term bmpr2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

BMPR2 Gene Set

From KEA Substrates of Kinases

substrates of the kinase BMPR2 from the curated KEA Substrates of Kinases dataset.

BMPR2 Gene Set

From MSigDB Cancer Gene Co-expression Modules

co-expressed genes for BMPR2 from the MSigDB Cancer Gene Co-expression Modules dataset.

BMPR2 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for BMPR2 from the Pathway Commons Protein-Protein Interactions dataset.

bmpr2mediated Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term bmpr2mediated in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.