Name

BTK Gene

Bruton agammaglobulinemia tyrosine kinase

The protein encoded by this gene plays a crucial role in B-cell development. Mutations in this gene cause X-linked agammaglobulinemia type 1, which is an immunodeficiency characterized by the failure to produce mature B lymphocytes, and associated with a failure of Ig heavy chain rearrangement. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2013]

btk Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term btk in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

BTK Gene Set

From Hub Proteins Protein-Protein Interactions

interacting proteins for hub protein BTK from the curated Hub Proteins Protein-Protein Interactions dataset.

BTK Gene Set

From KEA Substrates of Kinases

substrates of the kinase BTK from the curated KEA Substrates of Kinases dataset.

BTK Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for BTK from the Pathway Commons Protein-Protein Interactions dataset.

BTK Gene Set

From PhosphoSitePlus Substrates of Kinases

substrates of the kinase BTK from the curated PhosphoSitePlus Substrates of Kinases dataset.

G protein complex (Btk, Gng2, Gnb1) Gene Set

From CORUM Protein Complexes

proteins in the G protein complex (Btk, Gng2, Gnb1) protein complex from the CORUM Protein Complexes dataset.

Bash-Bnas2/Cmtm3-Btk-Erk2 complex Gene Set

From CORUM Protein Complexes

proteins in the Bash-Bnas2/Cmtm3-Btk-Erk2 complex protein complex from the CORUM Protein Complexes dataset.

G protein complex (BTK, GNG1, GNG2) Gene Set

From CORUM Protein Complexes

proteins in the G protein complex (BTK, GNG1, GNG2) protein complex from the CORUM Protein Complexes dataset.

btkinduced Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term btkinduced in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

btkdependent Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term btkdependent in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

BTK_KO_GDS1346_302_mouse_splenic B cells Gene Set

From GEO Signatures of Differentially Expressed Genes for Gene Perturbations

genes differentially expressed following the BTK_KO_GDS1346_302_mouse_splenic B cells gene perturbation from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.

BTK_knockout_2_GDS1346 Gene Set

From GEO Signatures of Differentially Expressed Genes for Kinase Perturbations

genes differentially expressed following the BTK_knockout_2_GDS1346 kinase perturbation from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.

BTK_mutant_1_GDS1346 Gene Set

From GEO Signatures of Differentially Expressed Genes for Kinase Perturbations

genes differentially expressed following the BTK_mutant_1_GDS1346 kinase perturbation from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.

Zinc finger, Btk motif Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Zinc finger, Btk motif protein domain from the InterPro Predicted Protein Domain Annotations dataset.