Name

C4A Gene

complement component 4A (Rodgers blood group)

This gene encodes the acidic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain is cleaved to release C4 anaphylatoxin, an antimicrobial peptide and a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus and type I diabetes mellitus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014]

c4a Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term c4a in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

C4A Gene Set

From NURSA Protein-Protein Interactions

interacting proteins for C4A from the NURSA Protein-Protein Interactions dataset.

C4A Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for C4A from the Pathway Commons Protein-Protein Interactions dataset.

c4a null Gene Set

From GAD Gene-Disease Associations

genes associated with the disease c4a null in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

c4a null haplotypes Gene Set

From GAD Gene-Disease Associations

genes associated with the disease c4a null haplotypes in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

c4aq0 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term c4aq0 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

c4a deficiency Gene Set

From OMIM Gene-Disease Associations

genes associated with the c4a deficiency phenotype from the curated OMIM Gene-Disease Associations dataset.