CASP4 Gene

caspase 4, apoptosis-related cysteine peptidase

This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, this gene induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

casp4 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term casp4 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

CASP4 Gene Set

From MSigDB Cancer Gene Co-expression Modules

co-expressed genes for CASP4 from the MSigDB Cancer Gene Co-expression Modules dataset.

CASP4 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for CASP4 from the Pathway Commons Protein-Protein Interactions dataset.