CASP6 Gene

caspase 6, apoptosis-related cysteine peptidase

This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspases 7, 8 and 10, and is thought to function as a downstream enzyme in the caspase activation cascade. Alternative splicing of this gene results in two transcript variants that encode different isoforms. [provided by RefSeq, Jul 2008]

casp6 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term casp6 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

CASP6 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for CASP6 from the Pathway Commons Protein-Protein Interactions dataset.