Name

CASP8 Gene

caspase 8, apoptosis-related cysteine peptidase

This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined. [provided by RefSeq, Jul 2008]

CASP8AP2 Gene

caspase 8 associated protein 2

This protein is highly similar to FLASH, a mouse apoptotic protein identified by its interaction with the death-effector domain (DED) of caspase 8. Studies of FLASH protein suggested that this protein may be a component of the death-inducing signaling complex that includes Fas receptor, Fas-binding adapter FADD, and caspase 8, and plays a regulatory role in Fas-mediated apoptosis. Alternative splicing results in multiple transcript variants encoding the same protein.[provided by RefSeq, Nov 2008]

casp8 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term casp8 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

CASP8 Gene Set

From Hub Proteins Protein-Protein Interactions

interacting proteins for hub protein CASP8 from the curated Hub Proteins Protein-Protein Interactions dataset.

CASP8 Gene Set

From MSigDB Cancer Gene Co-expression Modules

co-expressed genes for CASP8 from the MSigDB Cancer Gene Co-expression Modules dataset.

CASP8 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for CASP8 from the Pathway Commons Protein-Protein Interactions dataset.

CASP8-CHUK-IKBKB-MALT1-BCL10 complex Gene Set

From CORUM Protein Complexes

proteins in the CASP8-CHUK-IKBKB-MALT1-BCL10 complex protein complex from the CORUM Protein Complexes dataset.

Death induced signaling complex DISC (FAS, FADD, CASP8, CFLAR), membrane-associated, CD95L induced Gene Set

From CORUM Protein Complexes

proteins in the Death induced signaling complex DISC (FAS, FADD, CASP8, CFLAR), membrane-associated, CD95L induced protein complex from the CORUM Protein Complexes dataset.

FAS-FADD-CASP8-CASP10 complex Gene Set

From CORUM Protein Complexes

proteins in the FAS-FADD-CASP8-CASP10 complex protein complex from the CORUM Protein Complexes dataset.

FAS-FADD-CASP8 complex Gene Set

From CORUM Protein Complexes

proteins in the FAS-FADD-CASP8 complex protein complex from the CORUM Protein Complexes dataset.

BAR-BCL2-CASP8 complex Gene Set

From CORUM Protein Complexes

proteins in the BAR-BCL2-CASP8 complex protein complex from the CORUM Protein Complexes dataset.

Death induced signaling complex II (FADD, CASP8, CFLAR), cytosolic, CD95L induced Gene Set

From CORUM Protein Complexes

proteins in the Death induced signaling complex II (FADD, CASP8, CFLAR), cytosolic, CD95L induced protein complex from the CORUM Protein Complexes dataset.

CASP8-FADD-MALT1-BCL10 complex Gene Set

From CORUM Protein Complexes

proteins in the CASP8-FADD-MALT1-BCL10 complex protein complex from the CORUM Protein Complexes dataset.

casp8id Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term casp8id in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

casp8casp3 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term casp8casp3 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

casp8ap2 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term casp8ap2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

casp8652 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term casp8652 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

EPI-1006-1 (CASP8) Gene Set

From NURSA Protein Complexes

proteins in the EPI-1006-1 (CASP8) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

BL6193 (CASP8AP2) Gene Set

From NURSA Protein Complexes

proteins in the BL6193 (CASP8AP2) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

CASP8AP2 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for CASP8AP2 from the Pathway Commons Protein-Protein Interactions dataset.