Name

CASP9 Gene

caspase 9, apoptosis-related cysteine peptidase

This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein can undergo autoproteolytic processing and activation by the apoptosome, a protein complex of cytochrome c and the apoptotic peptidase activating factor 1; this step is thought to be one of the earliest in the caspase activation cascade. This protein is thought to play a central role in apoptosis and to be a tumor suppressor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]

casp9 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term casp9 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

CASP9 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for CASP9 from the Pathway Commons Protein-Protein Interactions dataset.

casp983cttt Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term casp983cttt in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.