Name

CBL Gene

Cbl proto-oncogene, E3 ubiquitin protein ligase

This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia. Mutations in this gene are also the cause of Noonan syndrome-like disorder. [provided by RefSeq, Mar 2012]

CBLL1 Gene

Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase

This gene encodes an E3 ubiquitin-ligase for the E-cadherin complex and mediates its ubiquitination, endocytosis, and degradation in the lysosomes. The encoded protein contains a RING-finger domain and is also thought to have a role in control of cell proliferation. A related pseudogene has been identified on chromosome X. Alternative splicing results in a non-coding transcript variant. [provided by RefSeq, Aug 2011]

CBLC Gene

Cbl proto-oncogene C, E3 ubiquitin protein ligase

This gene encodes a member of the Cbl family of E3 ubiquitin ligases. Cbl proteins play important roles in cell signaling through the ubiquitination and subsequent downregulation of tyrosine kinases. Expression of this gene may be restricted to epithelial cells, and alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]

CBLB Gene

Cbl proto-oncogene B, E3 ubiquitin protein ligase

CBLN4 Gene

cerebellin 4 precursor

This gene encodes a member of a family of small secreted proteins containing C1Q domains. Members of this family are involved in regulation of neurexin signalling during synapse development. The mouse homolog of the protein encoded by this gene competes with netrin to bind to the deleted in colorectal cancer receptor. [provided by RefSeq, Aug 2012]

CBLN2 Gene

cerebellin 2 precursor

CBLN3 Gene

cerebellin 3 precursor

Members of the precerebellin family, such as CBLN3, contain a cerebellin motif (see CBLN1; MIM 600432) and a C-terminal C1q signature domain (see MIM 120550) that mediates trimeric assembly of atypical collagen complexes. However, precerebellins do not contain a collagen motif, suggesting that they are not conventional components of the extracellular matrix (Pang et al., 2000 [PubMed 10964938]).[supplied by OMIM, Aug 2009]

CBLN1 Gene

cerebellin 1 precursor

This gene encodes a cerebellum-specific precursor protein, precerebellin, with similarity to the globular (non-collagen-like) domain of complement component C1qB. Precerebellin is processed to give rise to several derivatives, including the hexadecapeptide, cerebellin, which is highly enriched in postsynaptic structures of Purkinje cells. Cerebellin has also been found in human and rat adrenals, where it has been shown to enhance the secretory activity of this gland. [provided by RefSeq, Aug 2008]

cbl Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cbl in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

CBL Gene Set

From Hub Proteins Protein-Protein Interactions

interacting proteins for hub protein CBL from the curated Hub Proteins Protein-Protein Interactions dataset.

CBL Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for CBL from the Pathway Commons Protein-Protein Interactions dataset.

cbl mediated ligand-induced downregulation of egf receptors pathway Gene Set

From Biocarta Pathways

proteins participating in the cbl mediated ligand-induced downregulation of egf receptors pathway pathway from the Biocarta Pathways dataset.

METHYLCOBALAMIN DEFICIENCY, cblG TYPE Gene Set

From ClinVar Gene-Phenotype Associations

genes associated with the METHYLCOBALAMIN DEFICIENCY, cblG TYPE phenotype from the curated ClinVar Gene-Phenotype Associations dataset.

Methylmalonic aciduria cblA type Gene Set

From ClinVar Gene-Phenotype Associations

genes associated with the Methylmalonic aciduria cblA type phenotype from the curated ClinVar Gene-Phenotype Associations dataset.

METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA, cblJ TYPE Gene Set

From ClinVar Gene-Phenotype Associations

genes associated with the METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA, cblJ TYPE phenotype from the curated ClinVar Gene-Phenotype Associations dataset.

Methylmalonic aciduria, cblD type, variant 2 Gene Set

From ClinVar Gene-Phenotype Associations

genes associated with the Methylmalonic aciduria, cblD type, variant 2 phenotype from the curated ClinVar Gene-Phenotype Associations dataset.

Homocystinuria, cblD type, variant 1 Gene Set

From ClinVar Gene-Phenotype Associations

genes associated with the Homocystinuria, cblD type, variant 1 phenotype from the curated ClinVar Gene-Phenotype Associations dataset.

Homocystinuria-Megaloblastic anemia due to defect in cobalamin metabolism, cblE complementation type Gene Set

From ClinVar Gene-Phenotype Associations

genes associated with the Homocystinuria-Megaloblastic anemia due to defect in cobalamin metabolism, cblE complementation type phenotype from the curated ClinVar Gene-Phenotype Associations dataset.

Methylmalonic aciduria cblB type Gene Set

From ClinVar Gene-Phenotype Associations

genes associated with the Methylmalonic aciduria cblB type phenotype from the curated ClinVar Gene-Phenotype Associations dataset.

Methylmalonic acidemia with homocystinuria cblD Gene Set

From ClinVar Gene-Phenotype Associations

genes associated with the Methylmalonic acidemia with homocystinuria cblD phenotype from the curated ClinVar Gene-Phenotype Associations dataset.

CIN85-CBL-SH3GL2-EGFR complex, EGF stimulated Gene Set

From CORUM Protein Complexes

proteins in the CIN85-CBL-SH3GL2-EGFR complex, EGF stimulated protein complex from the CORUM Protein Complexes dataset.

CIN85-SH3GL3-CBL complex Gene Set

From CORUM Protein Complexes

proteins in the CIN85-SH3GL3-CBL complex protein complex from the CORUM Protein Complexes dataset.

SH3P2/OSTF1-CBL-SRC complex Gene Set

From CORUM Protein Complexes

proteins in the SH3P2/OSTF1-CBL-SRC complex protein complex from the CORUM Protein Complexes dataset.

Cbl-Crkl-Rapgef1 complex Gene Set

From CORUM Protein Complexes

proteins in the Cbl-Crkl-Rapgef1 complex protein complex from the CORUM Protein Complexes dataset.

LAT-PLC-gamma-1-p85-GRB2-CBL-VAV-SLP-76 signaling complex, C305 activated Gene Set

From CORUM Protein Complexes

proteins in the LAT-PLC-gamma-1-p85-GRB2-CBL-VAV-SLP-76 signaling complex, C305 activated protein complex from the CORUM Protein Complexes dataset.

CIN85-CBL-SH3GL2 complex Gene Set

From CORUM Protein Complexes

proteins in the CIN85-CBL-SH3GL2 complex protein complex from the CORUM Protein Complexes dataset.

Cbl-SLP-76-Grb2 complex, Fc receptor gamma-R1 stimulated Gene Set

From CORUM Protein Complexes

proteins in the Cbl-SLP-76-Grb2 complex, Fc receptor gamma-R1 stimulated protein complex from the CORUM Protein Complexes dataset.

PLC-gamma-1-LAT-c-CBL complex, OKT3 stimulated Gene Set

From CORUM Protein Complexes

proteins in the PLC-gamma-1-LAT-c-CBL complex, OKT3 stimulated protein complex from the CORUM Protein Complexes dataset.

Sh3kbp1-Cblb-Pdgfrb complex Gene Set

From CORUM Protein Complexes

proteins in the Sh3kbp1-Cblb-Pdgfrb complex protein complex from the CORUM Protein Complexes dataset.

CIN85 complex (CIN85, CRK, BCAR1, CBL, PIK3R1, GRB2, SOS1) Gene Set

From CORUM Protein Complexes

proteins in the CIN85 complex (CIN85, CRK, BCAR1, CBL, PIK3R1, GRB2, SOS1) protein complex from the CORUM Protein Complexes dataset.

SH3KBP1-CBLB-EGFR complex Gene Set

From CORUM Protein Complexes

proteins in the SH3KBP1-CBLB-EGFR complex protein complex from the CORUM Protein Complexes dataset.

CIN85-c-CBL complex Gene Set

From CORUM Protein Complexes

proteins in the CIN85-c-CBL complex protein complex from the CORUM Protein Complexes dataset.

MET-CIN85-SH3GL3-CBL complex, HGF stimulated Gene Set

From CORUM Protein Complexes

proteins in the MET-CIN85-SH3GL3-CBL complex, HGF stimulated protein complex from the CORUM Protein Complexes dataset.

EGFR-CBL-GRB2 complex Gene Set

From CORUM Protein Complexes

proteins in the EGFR-CBL-GRB2 complex protein complex from the CORUM Protein Complexes dataset.

SLP-76-Cbl-Grb2-Shc complex, Fc receptor gamma-R1 stimulated Gene Set

From CORUM Protein Complexes

proteins in the SLP-76-Cbl-Grb2-Shc complex, Fc receptor gamma-R1 stimulated protein complex from the CORUM Protein Complexes dataset.

ArgBP2a-CBL-PTK2B complex Gene Set

From CORUM Protein Complexes

proteins in the ArgBP2a-CBL-PTK2B complex protein complex from the CORUM Protein Complexes dataset.

FGFR2-c-Cbl-Lyn-Fyn complex Gene Set

From CORUM Protein Complexes

proteins in the FGFR2-c-Cbl-Lyn-Fyn complex protein complex from the CORUM Protein Complexes dataset.

CIN85-CBL complex Gene Set

From CORUM Protein Complexes

proteins in the CIN85-CBL complex protein complex from the CORUM Protein Complexes dataset.

Cbl-Cd2ap complex Gene Set

From CORUM Protein Complexes

proteins in the Cbl-Cd2ap complex protein complex from the CORUM Protein Complexes dataset.

Cbl-Cd2ap-Flt1 complex Gene Set

From CORUM Protein Complexes

proteins in the Cbl-Cd2ap-Flt1 complex protein complex from the CORUM Protein Complexes dataset.

Homocystinuria-Megaloblastic Anemia due to Defect in Cobalamin Metabolism, CblE Complementation Type Gene Set

From CTD Gene-Disease Associations

genes/proteins associated with the disease Homocystinuria-Megaloblastic Anemia due to Defect in Cobalamin Metabolism, CblE Complementation Type from the curated CTD Gene-Disease Associations dataset.

Methylmalonic Aciduria and Homocystinuria, CblD Type Gene Set

From CTD Gene-Disease Associations

genes/proteins associated with the disease Methylmalonic Aciduria and Homocystinuria, CblD Type from the curated CTD Gene-Disease Associations dataset.

Methylmalonic aciduria cblA type Gene Set

From CTD Gene-Disease Associations

genes/proteins associated with the disease Methylmalonic aciduria cblA type from the curated CTD Gene-Disease Associations dataset.

Methylcobalamin Deficiency, CblG Type Gene Set

From CTD Gene-Disease Associations

genes/proteins associated with the disease Methylcobalamin Deficiency, CblG Type from the curated CTD Gene-Disease Associations dataset.

Methylmalonic Aciduria and Homocystinuria, CblF Type Gene Set

From CTD Gene-Disease Associations

genes/proteins associated with the disease Methylmalonic Aciduria and Homocystinuria, CblF Type from the curated CTD Gene-Disease Associations dataset.

Methylmalonic aciduria cblB type Gene Set

From CTD Gene-Disease Associations

genes/proteins associated with the disease Methylmalonic aciduria cblB type from the curated CTD Gene-Disease Associations dataset.

methylmalonic aciduria and homocystinuria type cblc Gene Set

From DISEASES Text-mining Gene-Disease Assocation Evidence Scores

genes co-occuring with the disease methylmalonic aciduria and homocystinuria type cblc in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

cblvav Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cblvav in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

cbls Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cbls in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

cblcin85 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cblcin85 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

cbln2 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cbln2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

cbln1 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cbln1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

cblmediated Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cblmediated in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

cbldirected Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cbldirected in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

cblc Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cblc in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

cblb Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cblb in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

cbla Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cbla in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

cbldependent Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cbldependent in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

cblcin85endophilin Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cblcin85endophilin in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

cblfamily Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cblfamily in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Adaptor protein Cbl Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Adaptor protein Cbl protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Adaptor protein Cbl, SH2-like Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Adaptor protein Cbl, SH2-like protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Adaptor protein Cbl, PTB domain Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Adaptor protein Cbl, PTB domain protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Adaptor protein Cbl, EF hand-like Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Adaptor protein Cbl, EF hand-like protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Adaptor protein Cbl, N-terminal helical Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Adaptor protein Cbl, N-terminal helical protein domain from the InterPro Predicted Protein Domain Annotations dataset.

c-Cbl associated protein Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the c-Cbl associated protein protein domain from the InterPro Predicted Protein Domain Annotations dataset.

BL8719 (CBL) Gene Set

From NURSA Protein Complexes

proteins in the BL8719 (CBL) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

CBLC Gene Set

From NURSA Protein-Protein Interactions

interacting proteins for CBLC from the NURSA Protein-Protein Interactions dataset.

CBLL1 Gene Set

From NURSA Protein-Protein Interactions

interacting proteins for CBLL1 from the NURSA Protein-Protein Interactions dataset.

homocystinuria, cbld type, variant 1 Gene Set

From OMIM Gene-Disease Associations

genes associated with the homocystinuria, cbld type, variant 1 phenotype from the curated OMIM Gene-Disease Associations dataset.

methylmalonic aciduria and homocystinuria, cbld type Gene Set

From OMIM Gene-Disease Associations

genes associated with the methylmalonic aciduria and homocystinuria, cbld type phenotype from the curated OMIM Gene-Disease Associations dataset.

methylmalonic aciduria and homocystinuria, cblf type Gene Set

From OMIM Gene-Disease Associations

genes associated with the methylmalonic aciduria and homocystinuria, cblf type phenotype from the curated OMIM Gene-Disease Associations dataset.

methylmalonic aciduria and homocystinuria, cblc type Gene Set

From OMIM Gene-Disease Associations

genes associated with the methylmalonic aciduria and homocystinuria, cblc type phenotype from the curated OMIM Gene-Disease Associations dataset.

methylmalonic aciduria, cbld type, variant 2 Gene Set

From OMIM Gene-Disease Associations

genes associated with the methylmalonic aciduria, cbld type, variant 2 phenotype from the curated OMIM Gene-Disease Associations dataset.

methylmalonic aciduria and homocystinuria, cblj type Gene Set

From OMIM Gene-Disease Associations

genes associated with the methylmalonic aciduria and homocystinuria, cblj type phenotype from the curated OMIM Gene-Disease Associations dataset.

homocystinuria-megaloblastic anemia, cbl e type Gene Set

From OMIM Gene-Disease Associations

genes associated with the homocystinuria-megaloblastic anemia, cbl e type phenotype from the curated OMIM Gene-Disease Associations dataset.

homocystinuria-megaloblastic anemia, cblg complementation type Gene Set

From OMIM Gene-Disease Associations

genes associated with the homocystinuria-megaloblastic anemia, cblg complementation type phenotype from the curated OMIM Gene-Disease Associations dataset.

mental retardation, x-linked 3 (methylmalonic acidemia and homocysteinemia, cblx type ) Gene Set

From OMIM Gene-Disease Associations

genes associated with the mental retardation, x-linked 3 (methylmalonic acidemia and homocysteinemia, cblx type ) phenotype from the curated OMIM Gene-Disease Associations dataset.

methylmalonic aciduria, vitamin b12-responsive, due to defect in synthesis of adenosylcobalamin, cblb complementation type Gene Set

From OMIM Gene-Disease Associations

genes associated with the methylmalonic aciduria, vitamin b12-responsive, due to defect in synthesis of adenosylcobalamin, cblb complementation type phenotype from the curated OMIM Gene-Disease Associations dataset.

CBLB Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for CBLB from the Pathway Commons Protein-Protein Interactions dataset.

CBLC Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for CBLC from the Pathway Commons Protein-Protein Interactions dataset.

CBLN3 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for CBLN3 from the Pathway Commons Protein-Protein Interactions dataset.

CBLN4 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for CBLN4 from the Pathway Commons Protein-Protein Interactions dataset.

CBLL1 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for CBLL1 from the Pathway Commons Protein-Protein Interactions dataset.

CBLN2 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for CBLN2 from the Pathway Commons Protein-Protein Interactions dataset.

CBLN1 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for CBLN1 from the Pathway Commons Protein-Protein Interactions dataset.

Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC Gene Set

From Reactome Pathways

proteins participating in the Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC pathway from the Reactome Pathways dataset.

Defective MMAB causes methylmalonic aciduria type cblB Gene Set

From Reactome Pathways

proteins participating in the Defective MMAB causes methylmalonic aciduria type cblB pathway from the Reactome Pathways dataset.

Defective MMAA causes methylmalonic aciduria type cblA Gene Set

From Reactome Pathways

proteins participating in the Defective MMAA causes methylmalonic aciduria type cblA pathway from the Reactome Pathways dataset.

Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF Gene Set

From Reactome Pathways

proteins participating in the Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF pathway from the Reactome Pathways dataset.

Defective MTR causes methylmalonic aciduria and homocystinuria type cblG Gene Set

From Reactome Pathways

proteins participating in the Defective MTR causes methylmalonic aciduria and homocystinuria type cblG pathway from the Reactome Pathways dataset.

Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD Gene Set

From Reactome Pathways

proteins participating in the Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD pathway from the Reactome Pathways dataset.

Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Gene Set

From Reactome Pathways

proteins participating in the Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE pathway from the Reactome Pathways dataset.

Cobalamin (Cbl, vitamin B12) transport and metabolism Gene Set

From Reactome Pathways

proteins participating in the Cobalamin (Cbl, vitamin B12) transport and metabolism pathway from the Reactome Pathways dataset.

Regulation of signaling by CBL Gene Set

From Reactome Pathways

proteins participating in the Regulation of signaling by CBL pathway from the Reactome Pathways dataset.