Name

CCL5 Gene

chemokine (C-C motif) ligand 5

This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, functions as a chemoattractant for blood monocytes, memory T helper cells and eosinophils. It causes the release of histamine from basophils and activates eosinophils. This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor chemokine (C-C motif) receptor 5 (CCR5), and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Jul 2013]

ccl5 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term ccl5 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

CCL5 Gene Set

From Guide to Pharmacology Protein Ligands of Receptors

receptors of the CCL5 ligand (protein) from the curated Guide to Pharmacology Protein Ligands of Receptors dataset.

CCL5 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for CCL5 from the Pathway Commons Protein-Protein Interactions dataset.

ccl5ccr5 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term ccl5ccr5 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

ccl5ccr1 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term ccl5ccr1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

ccl5gag Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term ccl5gag in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

ccl5rantesinduced Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term ccl5rantesinduced in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

ccl5403 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term ccl5403 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

ccl528 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term ccl528 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

ccl5androgen Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term ccl5androgen in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

ccl5rantes Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term ccl5rantes in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

[125I]CCL5 (human) Gene Set

From Guide to Pharmacology Chemical Ligands of Receptors

receptors of the [125I]CCL5 (human) ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset.