Name

CDKN1B Gene

cyclin-dependent kinase inhibitor 1B (p27, Kip1)

This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Mutations in this gene are associated with multiple endocrine neoplasia type IV (MEN4). [provided by RefSeq, Apr 2014]

cdkn1b Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cdkn1b in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

CDKN1B Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for CDKN1B from the Pathway Commons Protein-Protein Interactions dataset.

cdkn1bp27 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cdkn1bp27 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

cdkn1b_00000000_mouse_embryonic_fibroblast_mef_lof_mouse_gpl6246_gse27672 Gene Set

From GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations

genes differentially expressed following the cdkn1b_00000000_mouse_embryonic_fibroblast_mef_lof_mouse_gpl6246_gse27672 transcription factor perturbation from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset.

cdkn1b_18180298_3t3_lof_mouse_gpl1261_gse9161 Gene Set

From GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations

genes differentially expressed following the cdkn1b_18180298_3t3_lof_mouse_gpl1261_gse9161 transcription factor perturbation from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset.